Comparison of Time Domain and Spectral Domain Optical Coherence Tomography in Measurement of Macular Thickness in Macular Edema Secondary to Diabetic Retinopathy and Retinal Vein Occlusion

Purpose. To evaluate macular thickness, agreement, and intraclass repeatability in three optical coherence tomography (OCT) devices: the time domain (TD) Stratus OCT and two spectral domain (SD) OCTs, Spectralis and Cirrus SD-OCT, in eyes with macular edema secondary to diabetic retinopathy (DR) and retinal vein occlusion (VO).Methods. In a prospective observational study at a university-based retina practice, retinal thickness tomography was performed simultaneously for fifty-eight patients (91 eyes) with DR and VO employing a time domain and two spectral domain OCTs. Agreement in macular measurements was assessed by constructing Bland-Altman plots. Intraclass repeatability was assessed by intraclass correlation coefficients (ICCs).Results. Based on the Bland-Altman plots for central macular thickness, there was low agreement between the measurements of Cirrus SD-OCT and Stratus OCT, Spectralis OCT and Stratus OCT, as well as Spectralis OCT and Cirrus SD-OCT among DR and RVO patients. All three devices demonstrated high intraclass repeatability, with ICC of 98% for Stratus OCT, 97% for Cirrus SD-OCT, and 100% for Spectralis OCT among DR patients. The ICC was 97% for Stratus OCT, 79% for Cirrus SD-OCT, and 91% for Spectralis OCT among RVO patients.Conclusion. There are low agreements among interdevice measurements. However, intraclass repeatability is high in both TD and SD-OCT devices.

Download Full-text

Comparison of Macular Thickness in Diabetic Macular Edema Using Spectral-Domain Optical Coherence Tomography and Time-Domain Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2012/959721 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Masashi Kakinoki ◽

Taichirou Miyake ◽

Osamu Sawada ◽

Tomoko Sawada ◽

Hajime Kawamura ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Time Domain ◽

Macular Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Corrected Visual Acuity ◽

The Mean ◽

Sd Oct

Purpose. To compare the macular thicknesses in diabetic macular edema (DME) measured with spectral-domain optical coherence tomography (SD-OCT) and time-domain (TD) OCT.Patients and Methods.The average macular thicknesses of 50 eyes of 29 patients with DME were measured using SD-OCT and TD-OCT.Results.The mean macular thicknesses measured with TD-OCT and SD-OCT were401.5±117.8 μm (mean ± SD) and446.2±123.5 μm, respectively. The macular thicknesses measured with the two devices were well correlated (Pearson's product moment correlation,r=0.977,P<0.001). A significant correlation was found between the best-corrected visual acuity and the retinal thickness measured by TD-OCT and SD-OCT (Pearson's product moment correlation, TD-OCT,r=0.34;P<0.05; SD-OCT,r=0.32;P<0.05).Discussion.The mean macular thickness measured with SD-OCT was about 45 μm thicker than that measured with TD-OCT. Attention should be paid when comparing data obtained using different OCT machines.

Download Full-text

TO ASSESS REDUCTION IN MACULAR EDEMA BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) FOLLOWING INJECTION OF BEVACIZUMAB IN CASES OF CENTRAL RETINAL VEIN OCCLUSION (CRVO)

International Journal of Advanced Research ◽

10.21474/ijar01/13272 ◽

2021 ◽

Vol 9 (08) ◽

pp. 347-351

Author(s):

Manjula Patnana ◽

◽

Nirmala Jyothi Pamu ◽

Shashwati Bhushan ◽

Ramakrishna Chatti ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Macular Oedema ◽

Spectral Domain ◽

Optical Coherence ◽

Vein Occlusion ◽

Central Retinal Vein ◽

Sd Oct

Aim: To study the reduction in macular oedema in Central Retinal Vein Occlusion cases following Intravitreal injection of Bevacizumab using Spectral Domain Optical Coherence Tomography. Methods: 50 patients diagnosed with Central Retinal Vein Occlusion with macular oedema of more than 300 microns on Spectral Domain Optical Coherence Tomography ( SD-OCT) ,who attended to Out patient Department of Government Regional Eye Hospital (GREH) between January 2020 to June 2020 were administered Intravitreal Injection of Bevacizumab (Avastin) 1.25mg in 0.05ml. Re-injections were given if SD-OCT showed persistence of macular oedema. In follow up visits, patients were evaluated with SD-OCT and Central macular thickness (CMT) was measured every month till 6 months from the date of first injection. Results: Out of 50 cases included in the study, there was reduction in macular oedema in 45 (90%) cases and 5% had persistence of macular edema. Conclusion: Intravitreal Bevacizumab is a safe and effective modality of treatment for reducing macular edema due to Central Retinal Vein Occlusion as per our study.

Download Full-text

Spectral-domain optical coherence tomography (SD-OCT) patterns and response to intravitreal bevacizumab therapy in macular edema associated with branch retinal vein occlusion

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-012-2067-8 ◽

2012 ◽

Vol 251 (2) ◽

pp. 501-508 ◽

Cited By ~ 35

Author(s):

Hae Min Kang ◽

Eun Jee Chung ◽

Yong Min Kim ◽

Hyoung Jun Koh

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Intravitreal Bevacizumab ◽

Spectral Domain ◽

Optical Coherence ◽

Vein Occlusion ◽

Sd Oct

Download Full-text

Comparison of Macular Thickness Measurements Using Swept-Source and Spectral-Domain Optical Coherence Tomography in Healthy and Diabetic Subjects

10.1101/2020.11.22.20236307 ◽

2020 ◽

Author(s):

Kun Xiong ◽

Wei Wang ◽

Xia Gong ◽

Wangting Li ◽

Yuting Li ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Macular Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Swept Source ◽

Macular Volume ◽

Conversion Equation ◽

Thickness Measurements ◽

Sd Oct

AbstractPurposeTo compare macular thicknesses measured using swept-source optical coherence tomography (SS-OCT) and spectral domain OCT (SD-OCT) in normal subjects, diabetics with diabetic retinopathy (DR) and diabetics without DR (NDR).MethodsWe analysed 510 normal eyes, 741 NDR eyes and 209 DR eyes. Mean macular thicknesses in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, central point thicknesses (CPT), and macular volume were measured by SS-OCT and SD-OCT. We assessed agreement between SS-OCT and SD-OCT measurements by intraclass correlation coefficients (ICC) and Bland-Altman plots, and established a conversion equation relating central subfield (CSF), CPT and macular volume between the two devices.ResultsMacular thickness measurements by SS-OCT were significantly thinner than those by SD-OCT. The mean CSF thickness in normal eyes measured by SD-OCT and SS-OCT were 226.6 ± 19.1 μm (male 236.1 ± 19.1 μm vs female 223.0 ± 17.9 μm, p < 0.0001) and 258.4 ± 19.8 μm. In all three groups, the agreement between SS-OCT and SD-OCT was excellent (all ICC ≥ 0.866). For CSF the conversion equation SD-OCT = 31.95 + 0.999 × SS-OCT was derived. Using the equation, with 99.6% and 97.6% of the predicted values for CSF fell within 10% of the actual measurements in DR and NDR eyes, respectively.ConclusionWe propose SS-OCT CSF thicknesses of 275 μm for males and 260 μm for females as the minimum criteria for macular edema in Chinese eyes. And SS-OCT measurements were significantly thinner than those of SD-OCT, we derived an equation to convert SS-OCT measurements to SD-OCT equivalents.

Download Full-text

Spectral-domain optical coherence tomography (SD-OCT) patterns in macular edema associated with retinal vein occlusion

Acta Ophthalmologica ◽

10.1111/j.1755-3768.2013.f036.x ◽

2013 ◽

Vol 91 ◽

pp. 0-0

Author(s):

M CHEOUR ◽

J BROUR ◽

F HACHICHA ◽

H LAJMI ◽

D MEHANAOUI ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Spectral Domain ◽

Optical Coherence ◽

Vein Occlusion ◽

Sd Oct

Download Full-text

External limiting membrane: retinal structural barrier in diabetic macular edema

International Journal of Retina and Vitreous ◽

10.1186/s40942-021-00284-x ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Sandeep Saxena ◽

Levent Akduman ◽

Carsten H. Meyer

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Spectral Domain ◽

Optical Coherence ◽

Barrier Effect ◽

External Limiting Membrane ◽

Ellipsoid Zone ◽

Structural Barrier ◽

Sd Oct

AbstractAdvances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.

Download Full-text