scholarly journals Mycobacterium tuberculosisInfection following Kidney Transplantation

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Karima Boubaker ◽  
Tahar Gargah ◽  
Ezzedine Abderrahim ◽  
Taieb Ben Abdallah ◽  
Adel Kheder

Introduction and Aims. Post-transplant tuberculosis (TB) is a problem in successful long-term outcome of renal transplantation recipients. Our objective was to describe the pattern and risk factors of TB infection and the prognosis in our transplant recipients.Patients and Methods. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed.Results. 16 patients (3,2%) developed post-transplant TB with a mean age of 32,5 ± 12,7 (range: 13–60) years and a mean post-transplant period of 36,6months (range: 12,3 months–15,9 years). The forms of the diseases were pulmonary in 10/16 (62,6%), disseminated in 3/16 (18,7%), and extrapulmonary in 3/16 (18,7%). Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18,7%) during treatment. Recurrences were observed in 4 cases after early stop of treatment. Two patients (12.5%) died.Conclusion. Extra pulmonary and disseminated tuberculosis were observed in third of our patients. More than 9months of treatment may be necessary to prevent recurrence.

2008 ◽  
Vol 21 (6) ◽  
pp. 547-553 ◽  
Author(s):  
Frank-Peter Tillmann ◽  
Marcus Jäger ◽  
Dirk Blondin ◽  
Martin Oels ◽  
Lars-Christian Rump ◽  
...  

2013 ◽  
Vol 95 (6) ◽  
pp. 889-895 ◽  
Author(s):  
Ernesto Paoletti ◽  
Diego Bellino ◽  
Luigina Marsano ◽  
Paolo Cassottana ◽  
Davide Rolla ◽  
...  

2001 ◽  
Vol 33 (1-2) ◽  
pp. 1242-1244 ◽  
Author(s):  
K.M Wong ◽  
W.L Chak ◽  
D.N.C Tsang ◽  
C.Y Cheung ◽  
Y.H Chan ◽  
...  

Author(s):  
N. N. Koloskova ◽  
V. N. Poptsov ◽  
A. О. Shevchenko

Heart transplantation is the «gold standard» of treatment severe heart failure. Immunosuppressive therapy aimed at the prevention of acute allograft rejection is the cornerstone of post-transplant management. In addition to its direct effects, immunosuppressive therapy is also involved in the generation of a number of post-transplant morbidities that limit the long-term outcome of heart transplant recipients. Given these data it appears that the individual tailoring of immunosuppressive therapy is of paramount importance in determining the outcome of heart transplantation. The goal of immunosuppressive therapy is to prevent rejection of the transplanted heart, while minimizing drug-related effects, such as infection, malignancy, diabetes, hypertension, and renal insuffi ciency. This review aimed is to analyze the protocols for the appointment of immunosuppressive therapy in various groups of recipients after heart transplantation.


2017 ◽  
Vol 3 (8) ◽  
pp. e190 ◽  
Author(s):  
Lyanne M. Kieneker ◽  
Oliver Hartmann ◽  
Joachim Struck ◽  
Andreas Bergmann ◽  
Ron T. Gansevoort ◽  
...  

2011 ◽  
Vol 146 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Paul Atkinson ◽  
Diana Y.Y. Chiu ◽  
Raj Sharma ◽  
Paul R. Kalra ◽  
Christopher Ward ◽  
...  

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