The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PET/CT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients

Purpose. The aim of this study was to determine if the preoperative maximum standardized uptake value (SUVmax) measured by 18F-FDG PET/CT in the primary tumor has prognostic value in the group of patients with endometrial cancer.Patients, Materials, and Methods. A total of one hundred one consecutive endometrial cancer patients, age range 40–82 years (mean 62 years) and FIGO I–IV stage, who underwent 18-FDG-PET/CT within two weeks prior radical surgery, were enrolled to the study. The maximum SUV was measured and compared with the clinicopathologic features of surgical specimens. The relationship between SUVmax and overall survival was analyzed.Results. The mean preoperative SUVmax was 14.34; range (3.90–33.80) and was significantly lower for FIGO I than for higher stages (P=0.0012), as well as for grade 1 than for grade 2 and 3 (P=0.018), deep myometrial invasion (P=0.0016) and for high risk group (P=0.0004). The analysis of survival ROC curve revealed SUVmax cut-off value of 17.7 to predict high risk of recurrence. Endometrial cancer patients with SUVmax higher than 17.7 characterized by lower overall survival.Conclusion. The preoperative SUVmax measured by 18F-FDG PET/CT is considered as an important indicator reflecting tumor aggressiveness which may predict poor prognosis. High value of SUVmax would be useful for making noninvasive diagnoses and deciding the appropriate therapeutic strategy for patients with endometrial cancer.

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Prognostic significance of SUVmax (maximum standardized uptake value) measured by [18F]FDG PET/CT in endometrial cancer

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-011-2057-9 ◽

2012 ◽

Vol 39 (5) ◽

pp. 840-845 ◽

Cited By ~ 46

Author(s):

Kazuhiro Kitajima ◽

Masato Kita ◽

Kayo Suzuki ◽

Michio Senda ◽

Yuji Nakamoto ◽

...

Keyword(s):

Endometrial Cancer ◽

Fdg Pet ◽

Prognostic Significance ◽

Standardized Uptake Value ◽

Maximum Standardized Uptake Value ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Metabolic parameters of sequential 18F-FDG PET/CT predict overall survival of esophageal cancer patients treated with (chemo-) radiation

Radiation Oncology ◽

10.1186/s13014-019-1236-x ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 1

Author(s):

Yimin Li ◽

Sebastian Zschaeck ◽

Qin Lin ◽

Sijia Chen ◽

Lili Chen ◽

...

Keyword(s):

Overall Survival ◽

Esophageal Cancer ◽

Cancer Patients ◽

Fdg Pet ◽

Metabolic Parameters ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Utility of flouro-deoxy-glucose positron emission tomography/computed tomography in the diagnostic and staging evaluation of patients with primary CNS lymphoma

CNS Oncology ◽

10.2217/cns-2019-0016 ◽

2019 ◽

Vol 8 (4) ◽

pp. CNS46 ◽

Cited By ~ 3

Author(s):

Meetakshi Gupta ◽

Tejpal Gupta ◽

Nilendu Purandare ◽

Venkatesh Rangarajan ◽

Ameya Puranik ◽

...

Keyword(s):

Fdg Pet ◽

Standardized Uptake Value ◽

Emission Tomography ◽

Whole Body ◽

Cns Lymphoma ◽

Maximum Standardized Uptake Value ◽

Positron Emission ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Aim: To prospectively assess the clinical utility of pretreatment flouro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with primary central nervous system (CNS) lymphoma (PCNSL). Materials & methods: Patients with suspected/proven PCNSL underwent baseline whole-body 18F-FDG-PET/CT. Maximum standardized uptake value and tumor/normal tissue ratios were compared between CNS lymphoma and other histological diagnoses. Results: The mean maximum standardized uptake value (27.5 vs 18.2; p = 0.001) and mean tumor/normal tissue ratio (2.34 vs 1.53; p < 0.001) of CNS lymphoma was significantly higher than other histologic diagnoses. Five of 50 (10%) patients with biopsy-proven CNS lymphomas had pathologically increased FDG-uptake at extraneuraxial sites uncovering systemic lymphoma. Conclusion: Pretreatment whole-body 18F-FDG-PET/CT provides valuable complementary information in the diagnostic and staging evaluation of patients with PCNSL to guide therapeutic decision-making.

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Prognostic value of maximum standardized uptake value measured by pretreatment 18F-FDG PET/CT in locally advanced head and neck squamous cell carcinoma

Clinical & Translational Oncology ◽

10.1007/s12094-017-1674-6 ◽

2017 ◽

Vol 19 (11) ◽

pp. 1337-1349 ◽

Cited By ~ 10

Author(s):

J. Cacicedo ◽

I. Fernandez ◽

O. del Hoyo ◽

A. Navarro ◽

A. Gomez-Iturriaga ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Fdg Pet ◽

Prognostic Value ◽

Locally Advanced ◽

Standardized Uptake Value ◽

Advanced Head ◽

Maximum Standardized Uptake Value ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Preoperative risk stratification using 18F-FDG PET/CT in women with endometrial cancer

Nuklearmedizin ◽

10.3413/nukmed-0375-10-12 ◽

2011 ◽

Vol 50 (05) ◽

pp. 204-213 ◽

Cited By ~ 21

Author(s):

H. J. Lee ◽

C. M. Hong ◽

B. I. Song ◽

H. W. Kim ◽

S. Kang ◽

...

Keyword(s):

Endometrial Cancer ◽

High Risk ◽

Risk Stratification ◽

Fdg Pet ◽

Figo Stage ◽

Low Risk ◽

Histologic Grade ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

SummaryThe aim of this study is to evaluate the usefulness of 18F-FDG PET/CT for preoperative stratification of high-risk and low-risk carcinomas in patients with endometrial cancer. Patients, methods: 60 women (mean age 53.8 ± 9.9 years) with endometrial cancer, who underwent 18F-FDG PET/CT for preoperative staging work-up, followed by primary cytoreductive surgery, were enrolled in this study. Maximum and mean standardized uptake values (SUVmax, SUVmean) of endometrial tumors were measured, and compared with the various clinicopathologic findings obtained after surgery. Tumour aggressiveness was classified as high-risk and low-risk carcinomas. Patients with stage I or II, endometrioid adenocarcinoma, histologic grade 1 or 2, invasion of less than half of the myometrium, maximum tumor size less than 2.0 cm, and absence of cervical invasion and lymphovascular space involvement (LVSI) were classified as the lowrisk carcinoma group. The remaining patients were classified as the high-risk carcinoma group. Results: In univariate analysis, SUVmax of the primary endometrial tumor was significantly higher in patients who were in a postmenopausal state (p = 0.047), large (> 2 cm) primary tumor (p <0.001), nonendometrioid subtype (p = 0.024), invasion of more than half of the myometrium (p = 0.020), or LVSI (p = 0.004). SUVmax differed significantly according to FIGO stage (p = 0.013) and histologic grade (p <0.001). In multivariate analysis, FIGO stage, histologic grade, LVSI, and maximum tumor size demonstrated a significant association with SUVmax (p <0.001; r = 0.843, r2 = 0.711). SUVmean showed similar results. Forty-one (68.3%) patients were diagnosed postoperatively as high-risk and 19 patients (31.7%) as low-risk carcinoma. Patients with high-risk carcinoma (12.1 ± 6.1) showed significantly higher SUVmax than patients with low-risk carcinoma (5.8 ± 2.8, p <0.001). The optimal SUVmax cut-off value of 8.7, determined by ROC analysis, revealed 75.6% sensitivity, 89.5% specificity, and 81.7% accuracy for risk stratification. Conclusion: High-risk endometrial cancer might be differentiated by means of higher SUVmax from low-risk endometrial cancer. 18F-FDG FDG PET/CT can be applied preoperatively for stratification of risk in patients with endometrial cancer.

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