Evaluating Different Aspects of Prospective Memory in Amnestic and Nonamnestic Mild Cognitive Impairment

Prospective memory, the inability to remember an intended action, is a common complaint, but not formally assessed in most clinical and research studies of mild cognitive impairment (MCI). In this study, patients with amnestic mild cognitive impairment (aMCI), non-amnestic cognitive impairment (naMCI), and cognitively normal (CN) elders were assessed using the Miami Prospective Memory Test (MPMT). A unique aspect of the paradigm was that participants were scored for intention to perform, accuracy in recollection for specific elements of the task, and the need for reminder cues. Excellent test-retest stability was obtained for MPMT Event-Related (ER), combined Time-Related (TR) subscales, and total MPMT score for aMCI subjects. MPMT impairments were observed in 48.6% of aMCI, 29.4% of naMCI, and 10.0% of normal elderly participants. Prospective memory deficits were common in participants with aMCI, and occurred in almost a third of naMCI participants. Intention to perform and need for reminder cues were significantly more impaired than retrospective memory for specific details of the task. It is concluded that assessment of different elements of prospective memory is important in MCI research and that inability to remember intended actions is a significant feature in those as risk for Alzheimer’s disease.

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Memory deficits for facial identity in patients with amnestic mild cognitive impairment (MCI)

PLoS ONE ◽

10.1371/journal.pone.0195693 ◽

2018 ◽

Vol 13 (4) ◽

pp. e0195693 ◽

Cited By ~ 3

Author(s):

Egemen Savaskan ◽

Daniel Summermatter ◽

Clemens Schroeder ◽

Hartmut Schächinger

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Memory Deficits ◽

Amnestic Mild Cognitive Impairment ◽

Facial Identity

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Prospective memory in amnestic mild cognitive impairment

Journal of the International Neuropsychological Society ◽

10.1017/s1355617709090596 ◽

2009 ◽

Vol 15 (3) ◽

pp. 407-415 ◽

Cited By ~ 46

Author(s):

STELLA KARANTZOULIS ◽

ANGELA K. TROYER ◽

JILL B. RICH

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Prospective Memory ◽

Amnestic Mild Cognitive Impairment ◽

Attention Switching ◽

Memory For Intentions ◽

Neuropsychological Evaluations ◽

Event Based ◽

Cue Detection ◽

Error Types

AbstractIndividuals with amnestic mild cognitive impairment (aMCI) often complain of difficulty remembering to carry out intended actions, consistent with findings of impaired prospective memory (PM) in this population. In this study, individuals with aMCI (N = 27) performed worse than healthy controls (N = 27) on the Memory for Intentions Screening Test (Raskin, 2004), including on time- and event-based subscales, and recognition of the intentions. The aMCI participants made more errors overall, but the proportion of the various error types did not differ between the two groups. Across all error types, both groups made more retrospective than prospective errors, especially on event-based PM tasks. Overall, the findings suggest that PM impairment in aMCI is associated with deficient cue detection involving both automatic (as in event-based tasks) and more strategic detection (as in time-based tasks) processes. These difficulties are likely due to a combination of problematic retrospective episodic memory (e.g., reduced encoding and/or consolidation of cue–intention pairings) and executive functions (e.g., decreased self-initiation, attention switching, and/or inhibition on memory tasks). Formal assessment of PM may help characterize the nature of the memory impairment among individuals with aMCI in clinical neuropsychological evaluations. (JINS, 2009, 15, 407–415.)

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P3-120: Separate functional neural correlates of memory deficits in amnestic mild cognitive impairment with high and low beta-amyloid burden

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.988 ◽

2015 ◽

Vol 11 (7S_Part_14) ◽

pp. P668-P668

Author(s):

Eun Hyun Seo ◽

Sang Hoon Kim ◽

Sang Hag Park ◽

Seong-Ho Kang ◽

I.L. Han Choo ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Beta Amyloid ◽

Memory Deficits ◽

Neural Correlates ◽

Amnestic Mild Cognitive Impairment ◽

Amyloid Burden

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IC-P1-037: Functional magnetic resonance imaging activation patterns in cognitively normal elderly, amnestic, and non-amnestic Mild Cognitive Impairment during a recognition memory task

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.048 ◽

2008 ◽

Vol 4 ◽

pp. T23-T24 ◽

Cited By ~ 1

Author(s):

Mary M. Machulda ◽

Matthew L. Senjem ◽

Glenn E. Smith ◽

Robert J. Ivnik ◽

Bradley F. Boeve ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Magnetic Resonance ◽

Memory Task ◽

Amnestic Mild Cognitive Impairment ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Activation Patterns ◽

Cognitively Normal

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Clinical Measures of Prospective Memory in Amnestic Mild Cognitive Impairment

Journal of the International Neuropsychological Society ◽

10.1017/s135561771100172x ◽

2012 ◽

Vol 18 (2) ◽

pp. 295-304 ◽

Cited By ~ 19

Author(s):

Jacinta Delprado ◽

Glynda Kinsella ◽

Ben Ong ◽

Kerryn Pike ◽

David Ames ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Prospective Memory ◽

Amnestic Mild Cognitive Impairment ◽

Retrospective Memory ◽

Single Trial ◽

Discriminative Ability ◽

Healthy Older Adults ◽

Event Based ◽

Complex Attention

AbstractRecent research has established that individuals with amnestic mild cognitive impairment (aMCI) have impaired prospective memory (PM); however, findings regarding differential deficits on time-based versus event-based PM have been less clear. Furthermore, the diagnostic utility of PM measures has received scant attention. Healthy older adults (n = 84) and individuals with aMCI (n = 84) were compared on the Cambridge Prospective Memory Test (CAMPROMPT) and two single-trial event-based PM tasks. The aMCI participants showed global impairment on all PM measures. Measures of retrospective memory and complex attention predicted both time and event PM performance for the aMCI group. Each of the PM measures was useful for discriminating aMCI from healthy older adults and the time- and event-based scales of the CAMPROMPT were equivalent in their discriminative ability. Surprisingly, the brief PM tasks were as good as more comprehensive measures of PM (CAMPROMPT) at predicting aMCI. Results indicate that single-trial PM measures, easily integrated into clinical practice, may be useful screening tools for identifying aMCI. As PM requires retrospective memory skills along with complex attention and executive skills, the interaction between these skills may explain the global PM deficits in aMCI and the good discriminative ability of PM for diagnosing aMCI. (JINS, 2012, 18, 295–304)

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