Prospective memory in amnestic mild cognitive impairment

2009 ◽  
Vol 15 (3) ◽  
pp. 407-415 ◽  
Author(s):  
STELLA KARANTZOULIS ◽  
ANGELA K. TROYER ◽  
JILL B. RICH
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Attention Switching ◽  
Memory For Intentions ◽  
Neuropsychological Evaluations ◽  
Event Based ◽  
Cue Detection ◽  
Error Types

AbstractIndividuals with amnestic mild cognitive impairment (aMCI) often complain of difficulty remembering to carry out intended actions, consistent with findings of impaired prospective memory (PM) in this population. In this study, individuals with aMCI (N = 27) performed worse than healthy controls (N = 27) on the Memory for Intentions Screening Test (Raskin, 2004), including on time- and event-based subscales, and recognition of the intentions. The aMCI participants made more errors overall, but the proportion of the various error types did not differ between the two groups. Across all error types, both groups made more retrospective than prospective errors, especially on event-based PM tasks. Overall, the findings suggest that PM impairment in aMCI is associated with deficient cue detection involving both automatic (as in event-based tasks) and more strategic detection (as in time-based tasks) processes. These difficulties are likely due to a combination of problematic retrospective episodic memory (e.g., reduced encoding and/or consolidation of cue–intention pairings) and executive functions (e.g., decreased self-initiation, attention switching, and/or inhibition on memory tasks). Formal assessment of PM may help characterize the nature of the memory impairment among individuals with aMCI in clinical neuropsychological evaluations. (JINS, 2009, 15, 407–415.)

Event-based prospective memory failure in amnestic mild cognitive impairment

2011 ◽  
Vol 49 (8) ◽  
pp. 2209-2216 ◽  
Author(s):  
Alberto Costa ◽  
Roberta Perri ◽  
Silvia Zabberoni ◽  
Francesco Barban ◽  
Carlo Caltagirone ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Memory Failure ◽  
Event Based

Detection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer’s disease etiology using a novel event-based prospective memory task

2009 ◽  
Vol 15 (1) ◽  
pp. 154-159 ◽  
Author(s):  
ALBERTO BLANCO-CAMPAL ◽  
ROBERT F. COEN ◽  
BRIAN A. LAWLOR ◽  
JOSEPH B. WALSH ◽  
TERESA E. BURKE
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Small Sample ◽  
Cutoff Score ◽  
Convenience Sample ◽  
Disease Etiology ◽  
Event Based

AbstractWe investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely used retrospective memory (RM) tests (Rivermead Paragraph Recall Test and CERAD-Word List Test), when detecting mild cognitive impairment of suspected Alzheimer’s disease etiology (MCI-AD) (N = 19) from normal controls (NC) (N = 21). Statistical analyses showed high discriminatory capacity of the PM task for detecting MCI-AD. The Non-Specific-Non-Salient condition proved particularly useful in detecting MCI-AD, possibly reflecting the difficulty of the task, requiring more strategic attentional resources to monitor for the PM cue. With a cutoff score of <4/10, the Non-Specific-Non-Salient condition achieved a sensitivity = 84%, and a specificity = 95%, superior to the most discriminative RM test used (CERAD-Total Learning: sensitivity = 83%; specificity = 76%). Results suggest that PM is an early sign of memory failure in MCI-AD and may be a more pronounced deficit than retrospective failure, probably reflecting the greater self-initiated retrieval demands involved in the PM task used. Limitations include the relatively small sample size, and the use of a convenience sample (i.e. memory clinic attenders and healthy active volunteers), reducing the generalizability of the results, which should be regarded as preliminary. (JINS, 2009, 15, 154–159.)

Clinical Measures of Prospective Memory in Amnestic Mild Cognitive Impairment

2012 ◽  
Vol 18 (2) ◽  
pp. 295-304 ◽  
Author(s):  
Jacinta Delprado ◽  
Glynda Kinsella ◽  
Ben Ong ◽  
Kerryn Pike ◽  
David Ames ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Prospective Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Retrospective Memory ◽  
Single Trial ◽  
Discriminative Ability ◽  
Healthy Older Adults ◽  
Event Based ◽  
Complex Attention

AbstractRecent research has established that individuals with amnestic mild cognitive impairment (aMCI) have impaired prospective memory (PM); however, findings regarding differential deficits on time-based versus event-based PM have been less clear. Furthermore, the diagnostic utility of PM measures has received scant attention. Healthy older adults (n = 84) and individuals with aMCI (n = 84) were compared on the Cambridge Prospective Memory Test (CAMPROMPT) and two single-trial event-based PM tasks. The aMCI participants showed global impairment on all PM measures. Measures of retrospective memory and complex attention predicted both time and event PM performance for the aMCI group. Each of the PM measures was useful for discriminating aMCI from healthy older adults and the time- and event-based scales of the CAMPROMPT were equivalent in their discriminative ability. Surprisingly, the brief PM tasks were as good as more comprehensive measures of PM (CAMPROMPT) at predicting aMCI. Results indicate that single-trial PM measures, easily integrated into clinical practice, may be useful screening tools for identifying aMCI. As PM requires retrospective memory skills along with complex attention and executive skills, the interaction between these skills may explain the global PM deficits in aMCI and the good discriminative ability of PM for diagnosing aMCI. (JINS, 2012, 18, 295–304)

scholarly journals Memory specificity training can improve working and prospective memory in amnestic mild cognitive impairment

2017 ◽  
Vol 11 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Golita Emsaki ◽  
Hamid Taher NeshatDoost ◽  
Mahgol Tavakoli ◽  
Majid Barekatain
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Brain Plasticity ◽  
Depression Scale ◽  
Cognitive Intervention ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Memory Specificity ◽  
Amnestic Mci

ABSTRACT Amnestic Mild Cognitive Impairment (MCI) is one of the cognitive profiles of aging. OBJECTIVE: In this study, Memory Specificity Training (MEST) was used as cognitive training in patients with amnestic MCI to understand the effectiveness of the intervention on memory dimensions. METHODS: Twenty patients that met the criteria for amnestic MCI were selected and randomly assigned to experimental (n=10) or control (n=10) groups. The experimental group received five sessions of training on memory specificity while the participants in the control group took part in two general placebo sessions. Participants were assessed before, immediately after, and three months after, the treatment using the Autobiographical Memory Test, the Prospective and Retrospective Memory Questionnaire, the Wechsler Memory Scale, and the Hospital Anxiety and Depression Scale. Analysis of variance was used to analyze the data. RESULTS: Results from both post-test and follow-up treatment indicated that MEST improves working and prospective memory (p<0.05). CONCLUSION: These findings support the effectiveness of MEST for MCI patients as a viable cognitive intervention. Also, the findings have implications for the role of brain plasticity in the effectiveness of this intervention.

scholarly journals Sustaining prospective memory functioning in amnestic mild cognitive impairment: A lifespan approach to the critical role of encoding.

2018 ◽  
Vol 32 (5) ◽  
pp. 634-644 ◽  
Author(s):  
Antonina Pereira ◽  
Mareike Altgassen ◽  
Lesley Atchison ◽  
Alexandre de Mendonça ◽  
Judi Ellis
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Critical Role ◽  
Amnestic Mild Cognitive Impairment ◽  
Memory Functioning

A Lack of Practice Effects on Memory Tasks Predicts Conversion to Alzheimer Disease in Patients With Amnestic Mild Cognitive Impairment

2020 ◽  
pp. 089198872094424
Author(s):  
Maria Stefania De Simone ◽  
Roberta Perri ◽  
Marta Rodini ◽  
Lucia Fadda ◽  
Massimo De Tollis ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Test Performance ◽  
Medial Temporal Lobe ◽  
Amnestic Mild Cognitive Impairment ◽  
Practice Effects ◽  
Large Set ◽  
Neuropsychological Evaluations

The aim of the current study was to test the accuracy of practice effects, that is, improvement in test performance due to repeated neuropsychological evaluations, in identifying patients with amnestic mild cognitive impairment (a-MCI) at greater risk of conversion to Alzheimer disease (AD). For this purpose, we conducted a longitudinal study of 54 patients diagnosed with a-MCI at the first assessment and followed-up for 4 years. During this time, 18 patients converted to AD. Baseline and 6- to 12-month follow-up performances on a large set of neuropsychological tests were analyzed to determine their diagnostic ability to predict later conversion to dementia. Results demonstrate that a lack of practice effects on episodic memory tests is an accurate prognostic indicator of late conversion to AD in a-MCI patients. In fact, even though the performance of both groups was substantially comparable at the baseline evaluation, stable a-MCI patients greatly improved their memory performance at retest after 6 to 12 months; instead, scores of converter a-MCI remained stable or decreased passing from baseline to follow-up. Standardized z-change scores on memory tasks, which were computed as a reliable measure of performance change, classified group membership with very good overall accuracy, which was higher than the classification of converter and stable a-MCIs provided by baseline or follow-up scores. We hypothesize that the lack of practice effects on memory tasks mirrors the early involvement of medial temporal lobe areas in converter a-MCI that are fundamental for the consolidation of new memory traces.

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