scholarly journals Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Quynh Vo ◽  
Timothy P. Gilmour ◽  
Kala Venkiteswaran ◽  
Jidong Fang ◽  
Thyagarajan Subramanian
Keyword(s):  
Rem Sleep ◽  
Muscle Activity ◽  
Sleep Disturbances ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Pattern ◽  
Dark Phase ◽  
Sleep Behavior ◽  
Long Run ◽  
Run Lengths

Sleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD. Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments. 24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model. In this study, we recorded 24-hour PSG from normal and HP rats. Recordings were scored into wake, rapid eye movement (REM), and non-REM (NREM). We then examined EEG to identify REM periods and EMG to check muscle activity during REM. Normal rats showed higher wakefulness (70–80%) during the dark phase and lower wakefulness (20%) during the light phase. HP rats showed 30–50% sleep in both phases, less modulation and synchronization to the light schedule(P<0.0001), and more long run lengths of wakefulness(P<0.05). HP rats also had more REM epochs with muscle activity than control rats(P<0.05). Our findings that the sleep architecture in the HP rat resembles that of PD patients demonstrate the value of this model in studying the pathophysiological basis of PD sleep disturbances and preclinical therapeutics for PD related sleep disorders including RBD.

M-H-074 TONIC AND PHASIC MUSCLE ACTIVITY IN REM SLEEP BEHAVIOR DISORDER

2011 ◽  
Vol 12 ◽  
pp. S42
Author(s):  
Mutsumi Okura ◽  
Hideko Sugita ◽  
Yoko Fujii ◽  
Noriko Yasumuro ◽  
Mitsutaka Taniguchi ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Muscle Activity ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

Observations on muscle activity in REM sleep behavior disorder assessed with a semi-automated scoring algorithm

2018 ◽  
Vol 129 (3) ◽  
pp. 541-547 ◽  
Author(s):  
Jesper Jeppesen ◽  
Marit Otto ◽  
Yoon Frederiksen ◽  
Allan K. Hansen ◽  
Tatyana D. Fedorova ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Muscle Activity ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Automated Scoring ◽  
Sleep Behavior ◽  
Scoring Algorithm

scholarly journals Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea

2017 ◽  
Vol 33 ◽  
pp. 23-29 ◽  
Author(s):  
Stuart J. McCarter ◽  
Erik K. St. Louis ◽  
David J. Sandness ◽  
Ethan J. Duwell ◽  
Paul C. Timm ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Rem Sleep ◽  
Muscle Activity ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Obstructive Sleep

scholarly journals Relations of non-motor symptoms and dopamine transporter binding in REM sleep behavior disorder

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Petr Dušek ◽  
Veronika Lorenzo y Losada Ibarburu ◽  
Ondrej Bezdicek ◽  
Irene Dall’antonia ◽  
Simona Dostálová ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Rem Sleep ◽  
Muscle Activity ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Motor Symptoms ◽  
Sleep Behavior ◽  
Binding Ratio ◽  
Dat Spect ◽  
Non Motor Symptoms

Abstract The aim of this study was to evaluate associations of motor and non-motor symptoms with dopamine transporter binding in prodromal stage of synucleinopathies. We examined 74 patients with idiopathic REM sleep behavior disorder (RBD), which is a prodromal synucleinopathy, and 39 controls using Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Montreal Cognitive Assessment, University of Pennsylvania Smell Identification Test (UPSIT), Farnsworth-Munsell 100 hue test, orthostatic test, Scales for Outcomes in PD-Autonomic, Beck depression inventory-II, State-Trait Anxiety Inventory, and video-polysomnography. Electromyographic muscle activity during REM sleep was quantified according to Sleep Innsbruck-Barcelona criteria. In 65 patients, dopamine transporter single-photon emission computed tomography (DAT-SPECT) imaging was performed, putaminal binding ratio was calculated and scans were classified as normal, borderline, or abnormal. Compared to controls, RBD patients had significantly more severe scores in all examined tests. Patients with abnormal DAT-SPECT had higher MDS-UPDRS motor score (p = 0.006) and higher prevalence of orthostatic hypotension (p = 0.008). Putaminal binding ratio was positively associated with UPSIT score (p = 0.03) and negatively associated with tonic (p = 0.003) and phasic (p = 0.01) muscle activity during REM sleep. These associations likely reflect simultaneous advancement of underlying pathology in substantia nigra and susceptible brainstem and olfactory nuclei in prodromal synucleinopathy.

scholarly journals Excessive Muscle Activity Increases Over Time in Idiopathic REM Sleep Behavior Disorder

SLEEP ◽  
2009 ◽  
Vol 32 (9) ◽  
pp. 1149-1153 ◽  
Author(s):  
Alex Iranzo ◽  
Pietro Luca Ratti ◽  
Jordi Casanova-Molla ◽  
Mónica Serradell ◽  
Isabel Vilaseca ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Muscle Activity ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Over Time

scholarly journals Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder

2021 ◽  
Vol 10 (20) ◽  
pp. 4709
Author(s):  
Hyunjin Jo ◽  
Dongyeop Kim ◽  
Jooyeon Song ◽  
Sujung Choi ◽  
Eunyeon Joo
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Rem Sleep ◽  
Sleep Disturbances ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Cpap Therapy ◽  
Sleep Behavior ◽  
Obstructive Sleep

Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 patients with idiopathic RBD (iRBD) and 44 patients with symptomatic RBD (sRBD) with a neurodegenerative disease). Results: Among 226 patients with RBD (male, 61.5%), the mean age at RBD onset and mean disease duration were 59.4 ± 10.5 and 5.9 ± 5.6 years, respectively. Further, 111 (49.1%) patients had periodic limb movements during sleep (PLMS, PLM index ≥ 15/h), while 110 patients (48.7%) had comorbid obstructive sleep apnea (OSA, respiratory disturbance index ≥ 15/h). There was a positive correlation between age at RBD onset and the apnea-hypopnea index and Pittsburgh Sleep Quality Index. Compared to patients with iRBD, patients with sRBD showed a lower N3 sleep (3.3 ± 5.0 vs. 1.6 ± 3.1%, p = 0.004) and higher periodic limb movement index (36.3 ± 31.8 vs. 56.9 ± 47.5/h, p = 0.021) at the baseline. Among the 186 patients with iRBD, 18 (8.0%) developed neurodegenerative diseases (converters, mean follow-up duration: 2.5 ± 1.6 years) and 164 did not (non-converters, mean follow-up 2.4 ± 2.2 years). There was no significant between-group difference in the demographics and baseline clinical features. Continuous positive airway pressure (CPAP) therapy was prescribed in 101 patients with OSA; among them, 71 (70%) patients agreed to use it. CPAP improved dream enactment behaviors. Conclusion: In our study, 8.0% of patients with iRBD showed phenoconversion within a mean follow-up duration of 2.5 years. Polysomnographic parameters could not predict phenoconversion to neurodegenerative disease. However, approximately half of the patients with RBD presented with significant sleep disorders, including OSA or PLMS. CPAP therapy may alleviate RBD symptoms in patients with RBD-OSA.

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