scholarly journals Rapid Progression of Primary Sclerosing Cholangitis Complicated with Ulcerative Colitis

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Piotr Pardak ◽  
Ewa Walczak ◽  
Rafał S. Filip
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Liver Transplant ◽  
Primary Sclerosing Cholangitis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Unknown Etiology ◽  
Rapid Progression ◽  
Inflammatory Bowel ◽  
Progressive Course

Primary sclerosing cholangitis is a cholestatic condition with unknown etiology and long-standing, progressive course, leading to cirrhosis and requiring orthotropic liver transplant. In approximately 80%, primary sclerosing cholangitis is accompanied by inflammatory bowel disease, and in most cases the recognition of bowel disease precedes the diagnosis of primary sclerosing cholangitis. We describe a case of 22-year-old male diagnosed simultaneously with primary sclerosing cholangitis and ulcerative colitis, with a medical history suggesting uncommon prior development of the liver disease. Five months after the initial diagnosis, we observed advanced lesions of bile tree due to progression of primary sclerosing cholangitis, which led to the unusually fast necessity for the orthotopic liver transplant.

S1017 Colonoscopic Surveillance in Inflammatory Bowel Disease Post Liver Transplant for Primary Sclerosing Cholangitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-814
Author(s):  
Gokulan Pavendranathan ◽  
Warwick Selby ◽  
Nicholas A. Shackel ◽  
Simone I. Strasser ◽  
Geoffrey W. McCaughan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Transplant ◽  
Primary Sclerosing Cholangitis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Colonoscopic Surveillance ◽  
Inflammatory Bowel

scholarly journals Atypical Perinuclear Antineutrophil Cytoplastmic Antibodies after Colectomy in Inflammatory Bowel Disease

1997 ◽  
Vol 11 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Hugh J Freeman ◽  
Brenda Roeck ◽  
Dana V Devine ◽  
Cedric J Carter
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Primary Sclerosing Cholangitis ◽  
Clinical Diagnosis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Serological Marker ◽  
Pelvic Pouch ◽  
Inflammatory Bowel

Atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) have been detected in most patients with ulcerative colitis and primary sclerosing cholangitis. Persistent atypical p-ANCA have been observed in ulcerative colitis patients with a prior proctocolectomy, especially with pouchitis, suggesting that this serological marker might be predictive of subsequent development of chronic or refractory pouchitis. This study prospectively evaluated this serological marker in 24 consecutive patients with inflammatory bowel disease and prior colectomies (12 with a clinical diagnosis of ulcerative colitis and 12 with a clinical diagnosis of Crohn's disease involving the colon). Of these, 14 were positive, including 11 with extensive ulcerative colitis and three with Crohn's disease. Although two of three ulcerative colitis patients with pouchitis were positive, eight of eight ulcerative colitis patients having a pelvic pouch with no pouchitis were also positive, as was a patient who elected to have an end-ileostomy (Brooke's ileostomy). Two patients had abnormal liver chemistry tests. Both had end-stage primary sclerosing cholangitis treated with liver transplantation and were positive for this serological marker. Although atypical p-ANCA may be a marker of persistent inflammation in pelvic pouch patients, a positive test result should not be used for prognosis or as a decision-making parameter for pelvic pouch procedures.

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