scholarly journals Reconstruction of Elbow by Free Fibular Graft in a Case of Osteoclastoma of Proximal Ulna: A Rare Case Report

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Kiran Kalaiah ◽  
S. G. Thejaswi ◽  
Marula Siddappa
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
English Literature ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Fibular Graft ◽  
Range Of Movement ◽  
Proximal Ulna ◽  
Rare Case Report ◽  
Rare Location

Giant cell tumour is a benign aggressive bone tumour. Most commonly, it is seen in epiphysiometaphyseal region around knee and distal radius. Proximal ulna is a rare location for giant cell tumour. According to reports, only 4 such cases have been reported in English literature. We report one such case of giant cell tumour of proximal ulna. Patient presented with painless, progressive swelling around right elbow since 4 months. Proximal ulna along with tumour was resected and elbow was reconstructed using nonvascularized free fibular graft. At two years of follow-up, patient is tumour-free and has functional range of movement in elbow. We are reporting the case because of its rare location and for the indigenous treatment modality of using free fibular graft for elbow reconstruction.

scholarly journals Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Raja Amri ◽  
Slim Charfi ◽  
Mohamed Jemaà ◽  
Nabil Miled ◽  
Fathia Slimi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Bone Development ◽  
Bone Tumour ◽  
Growth Factor Receptor ◽  
Kinase Domain ◽  
Cell Tumour ◽  
Pten Gene ◽  
Pik3ca Mutations ◽  
The Stability

Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) family and its downstream effectors in the development and recurrence of GCTB. For this purpose, we used a cohort of 32 GCTB patients and we evaluated the clinicohistological features and the expression of RANKL, EGFR, and HER2. The mutation status of KRAS, PI3KCA, and PTEN gene as potential oncogene involved in GCTB was also evaluated. We found a significant correlation between advanced histological stages, overexpression of EGFR/HER2, and tumour recurrence. Moreover, two mutations were found in the PIK3CA gene: a missense mutation, 1634A>C, detected for the first time in GCTB patients, without influencing the stability of the protein, and a frameshift mutation, c.1658_1659delGTinsC, causing the loss of the protein kinase domain. Altogether, these results suggest that overexpression of HER2/EGFR, Campanacci, and histological stages could be used as a novel prognostic marker for GCTB recurrence.

scholarly journals Use of a Distal Radius Endoprosthesis Following Resection of a Bone Tumour: A Case Report

Sarcoma ◽  
2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Kishan Gokaraju ◽  
Kesavan Sri-Ram ◽  
James Donaldson ◽  
Michael T. R. Parratt ◽  
Gordon W. Blunn ◽  
...  
Keyword(s):  
Case Report ◽  
Distal Radius ◽  
Giant Cell Tumour ◽  
English Literature ◽  
Bone Tumour ◽  
Surgical Excision ◽  
Prosthetic Replacement ◽  
Range Of Movement ◽  
Suitable Alternative ◽  
Adequate Pain Relief

Limited literature is available on the reconstruction of the distal radius using prosthetic replacement following resection of a bone tumour. We present the first reported case, in the English literature, of the use of an entirely metal endoprosthesis for the reconstruction of the distal radius. This case involves a 66-year-old male who was treated for giant cell tumour of the distal radius with surgical excision of the lesion and replacement of the defect using a predominantly titanium endoprosthesis. He was followed-up for 56 months following surgery and had a good functional outcome with no associated pain or complications. We propose that the use of a primarily titanium endoprosthesis for the reconstruction of a bone defect of the distal radius is a suitable alternative, providing good function of the forearm with satisfactory range of movement at the wrist and adequate pain relief.

scholarly journals Quality of life in patients with bone tumour

2018 ◽  
Vol 51 ◽  
pp. 02012
Author(s):  
Olga Shchelkova ◽  
Ekaterina Usmanova
Keyword(s):  
Quality Of Life ◽  
Bone Metastases ◽  
Social Functioning ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Primary Bone ◽  
Primary Bone Tumours

Introduction – in the last decades, scientific research of health related quality of life (QoL) is developing fast worldwide. QoL concept pays attention to emotional experience of disease in patients, particularly to personal sense of possibility to satisfy actual needs and possibility of full social functioning in spite of disease specific limitations. The aim of the study was to reveal the basic aspects and personality factors of QoL in patients with bone tumour. Results: the study revealed that patients with bone metastases assess their health significantly worse than other patients. Besides, patients with osteosarcoma evaluate their general health higher than patients with giant cell tumour. Social functioning in patients with chondrosarcoma is higher than in patients with bone metastases and patients with giant cell tumour. Patients with chondrosarcoma have higher physical functioning and less restricted in daily activities than patients with bone metastases. Patients with bone metastases have the most intensive pain among all patients. Moreover, the study revealed personality significant influence on QoL related to bone tumour. Conclusion – patients with bone metastasis have lower QoL compared to patients with primary bone tumours. Patients with giant cell tumour have the worth quality of life among patients with primary bone tumours. Furthermore the results revealed differences in QoL parameters associated with personality characteristics in patients with bone tumour.

scholarly journals Giant cell tumour of clavicle: Occurrence of a common tumour in a rare location

2016 ◽  
Vol 29 ◽  
pp. 51-55 ◽  
Author(s):  
Kavin Khatri ◽  
Jagdeep Singh ◽  
Anoop Kalia ◽  
Anshul Dahuja
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Rare Location

Giant cell tumour of EHL tendon sheath in young: a rare case report and review of the literature

2021 ◽  
Vol 14 (9) ◽  
pp. e242980
Author(s):  
Subodh Kumar Pathak ◽  
Abhijeet Ashok Salunke ◽  
Jagandeep Singh Virk ◽  
Naveen Kumar
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Tendon Sheath ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Cell Tumour ◽  
Tumour Mass ◽  
En Bloc ◽  
Second Metatarsal ◽  
Rare Case Report

Giant cell tumour of tendon sheath also known as benign synovioma is a slow-growing benign tumour originating from tendon sheath, ligaments or bursa. We present a case of swelling over the left foot of 7-month duration in 11-year-old boy diagnosed as giant cell tumour of tendon sheath. There was an extensive pressure effect of tumour mass on the second metatarsal evident by scalloping. Local excision was planned and executed, and reduction in scalloping was evident at 26-month follow-up with no recurrence. We conclude that en bloc resection of tumour with a hydrogen peroxide lavage may result in a favourable prognosis without recurrence.

scholarly journals Giant-cell tumour of proximal radius in a 50-year-old female with wrist drop: a rare case report

2017 ◽  
Vol 12 (3) ◽  
pp. 193-196
Author(s):  
Anshul Dahuja ◽  
Rashmeet Kaur ◽  
Shiraz Bhatty ◽  
Simmi Garg ◽  
Kapil Bansal ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Rare Case ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Proximal Radius ◽  
Rare Case Report ◽  
Wrist Drop
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