scholarly journals Association between Neurofibromatosis Type 1 and Breast Cancer: A Report of Two Cases with a Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yoon Nae Seo ◽  
Young Mi Park
Keyword(s):  
Breast Cancer ◽  
Neurofibromatosis Type 1 ◽  
Malignant Tumors ◽  
Genetic Diseases ◽  
Neurofibromatosis Type ◽  
Review Of The Literature ◽  
Increased Risk

Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases in humans and is associated with various benign and malignant tumors, including breast cancer. However, an increased risk of breast cancer in NF1 patients has not been widely recognized or accepted. Here, we report two cases of breast cancer in NF1 patients and review the literature on the association between NF1 and breast cancer.

scholarly journals Increased risk of breast cancer in neurofibromatosis type 1: current insights

2017 ◽  
Vol Volume 9 ◽  
pp. 531-536 ◽  
Author(s):  
Sacha J Howell ◽  
Kimberley Hockenhull ◽  
Zena Salih ◽  
D Gareth Evans
Keyword(s):  
Breast Cancer ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Increased Risk

scholarly journals Breast cancer associated with neurofibromatosis type 1: a case series and review of the literature

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Jihane Khalil ◽  
Mohamed Afif ◽  
Hanan Elkacemi ◽  
Meryem Benoulaid ◽  
Tayeb Kebdani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neurofibromatosis Type 1 ◽  
Case Series ◽  
Neurofibromatosis Type ◽  
Review Of The Literature

scholarly journals Phenotype–Genotype Correlation in Children with Neurofibromatosis Type 1

2018 ◽  
Vol 49 (03) ◽  
pp. 180-184 ◽  
Author(s):  
Sandrine Vaessen ◽  
Saskia Bulk ◽  
Julie Harvengt ◽  
Jean-Paul Misson ◽  
Christophe Barrea
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Malignant Tumors ◽  
Phenotypic Expression ◽  
Neurofibromatosis Type ◽  
Autosomal Dominant Disorder ◽  
Complete Penetrance ◽  
Increased Risk ◽  
Intrafamilial Variability ◽  
Genotype Correlation

AbstractNeurofibromatosis type 1 (NF1) is a common autosomal dominant disorder with an incidence of ∼1 in 4,000 live births. Neurofibromin, the gene product, is ubiquitously expressed at high levels in the nervous system and functions as a tumor suppressor. Haploinsufficiency of neurofibromin through mutation leads to an increased risk of developing benign and malignant tumors in affected individuals. Although NF1 has complete penetrance, it displays considerable inter- and intrafamilial variability in phenotypic expression which poses disease prediction and management problems. Some NF1 genotype–phenotype correlations have been described. To evaluate the genetic component of variable expressivity in NF1, we examined the phenotypic correlations between affected relatives in 52 NF1 patients from 45 families.

scholarly journals Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer

2017 ◽  
Vol 57 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Xia Wang ◽  
Jamie K. Teer ◽  
Renee N. Tousignant ◽  
Albert M. Levin ◽  
David Boulware ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Genomic Profiling

Breast cancer in a patient with neurofibromatosis type 1

2017 ◽  
Vol 24 (4) ◽  
pp. 666-668
Author(s):  
Mandeep Garg ◽  
Nidhi Prabhakar ◽  
Veenu Singla ◽  
Tulika Singh ◽  
Gurpreet Singh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type
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