scholarly journals Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Adetola Olubunmi Daramola ◽  
Mosebolatan Olatokunboh Odubanjo ◽  
Fred John Obiajulu ◽  
Nzechukwu Zimudo Ikeri ◽  
Adekunbiola Aina Fehintola Banjo
Keyword(s):  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Background. Management of breast lumps can be challenging in resource poor settings. Fine-needle aspiration cytology (FNAC) especially when used with cell block can help improve affordability for the patients.Objective. To determine the diagnostic accuracy of FNAC of palpable breast lesions within a 5-year period.Methods. The findings obtained from FNAC of palpable breast lumps seen at the FNAC clinic of our department from January 2007 to December 2011 were retrieved and correlated with findings on histology of excisional biopsies.Results. A total of 1790 patients had FNAC of breast lumps during the 5-year period; 436 of them subsequently had biopsies. Our results compare favourably with the measures of test performance of the UK NHS Breast Screening Programme shown in brackets: absolute sensitivity 95.4% (>70%), complete sensitivity 99.2% (>90%), full specificity 88.9% (>65%), positive predictive value 99.6% (>99%), false-negative rate 0.8% (<4%), false-positive rate 0.4% (<0.5%), inadequate rate 3.2% (<15%), and suspicious rate 10.2% (<15%).Conclusion. Breast FNACs compare very well with histology of excisional biopsies and in experienced hands are extremely useful in the management of breast lumps. Further studies assessing the diagnostic accuracy of FNAC and cell blocks in our setting are recommended.

scholarly journals Fine Needle Aspiration Cytology of Palpable Breast Lumps - Their Cytological Spectrum and Histopathological Correlation

KYAMC Journal ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 780-786
Author(s):  
Shaheen Akter ◽  
Md Jahidul Islam ◽  
Md Shariful Haque
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Palpable Breast ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Background: With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lumps has been revolutionized and it has high sensitivity and specificity.Aim: In this study we analyze the spectrum of FNAC diagnoses in breast lumps and compare the diagnostic accuracy of fine FNAC in differentiating the benign and malignant lesions of breast lumps with histopathological correlation.Materials & Methods: Two years prospective study was conducted in our institution and in that 490 aspirations, including 6 bilateral were performed. Suppurative and inflammatory lesions were excluded from the total aspirates. The cytological diagnosis was classified into 3 groups benign, suspicious and malignant. After this reporting all the available 94 cases were later subjected to mastectomy or open/excision biopsy and followed-up by histopathological confirmation. Later diagnostic accuracy of cytology reporting was compared with that of histopathology.Results: A total of 490 FNAC cases were reported including 373 as benign, 4 as suspicious for carcinoma and 113 as carcinoma. Majorities were premenopausal females and commonest age group was 31-40 years. Among them only 94 cases were followed-up by histopathologic confirmation. In histopathological correlation study, we had accuracy rate of 100% for benign lesion and 92.10% for malignant lesion with false negative rate of 7.90% and false positive rate of zero with fine needle aspiration cytology in the diagnosis of palpable breast lump. The overall sensitivity of fine needle aspiration in diagnosing the palpable breast lump is 92.10%, specificity is 100%, positive predictive value is 100% and negative predictive value is 94.91%.Conclusion: FNAC in experienced hands is a very useful tool with very high specificity and rare false positive result. Sensitivity can be further improved with clinical and imaging correlation.KYAMC Journal Vol. 7, No.-2, Jan 2017, Page 780-786

False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions

Breast Cancer ◽  
2007 ◽  
Vol 14 (4) ◽  
pp. 388-392 ◽  
Author(s):  
Takashi Ishikawa ◽  
Yohei Hamaguchi ◽  
Mikiko Tanabe ◽  
Nobuyoshi Momiyama ◽  
Takashi Chishima ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology

scholarly journals FINE NEEDLE ASPIRATION CYTOLOGY OF BREAST LUMP IN T.U. TEACHING HOSPITAL

2003 ◽  
Vol 41 (143) ◽  
pp. 388-91
Author(s):  
Jagat Singh Pandey ◽  
G Sayami ◽  
S Dali ◽  
H G Shrestha ◽  
B Shrestha ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Rapid Diagnostic Method ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

This is a retrospective study of fine needle aspiration cytology of breast lesionsperformed between May 1998 and April 2000. During this period, a total of 2001 fineneedle aspirations were done in the Tribhuvan Universtiy Teaching Hospital (TUTH),of which 470 (23.48 %) were of the breast. Fibrocystic disease found to be the mostfrequent and was diagnosed in 183 cases (38.9%). Fibroadenoma was the third commonpathological condition, numbering 61 (12.9%). Malignant conditions of the breastwere 72 cases (15.3%).During these two years, histological diagnosis was available in 154 cases. Histologicalexamination revealed benign conditions in 74 cases (48%), malignancy in 59 cases(38.3%) and inflammatory & lactational changes in 21 cases (13.7%). Out of these154 cases, 71 cases had also undergone fine needle aspiration cytology. The 36 casesdiagnosed as benign cytologically, 34 cases were also benign histologically, whereas 2cases turned out to be malignant. Out of 37 cases that were histologically malignant,on cytology 35 cases were diagnosed as malignant. The sensitivity and specificity ofcytopathological diagnosis for breast lesions was 100% and 94.6% respectively.Inflammatory lesions correlated well cytologically and histolgically.FNAC is a safe and rapid diagnostic method for evaluation of various lesions. However,there are possibilities of false negative and false positive results because of wide rangeof appearance of breast lesions.Key Words: Breast lumps, Fine Needle Aspiration Cytology, Benign Lesions,Malignant Lesions, Histopathology and Correlation.

scholarly journals A CORRELATIONAL STUDY BETWEEN FINE NEEDLE ASPIRATION CYTOLOGY AND HISTOPATHOLOGY OF PALPABLE BREAST LUMPS

2021 ◽  
Vol 7 (4) ◽  
pp. 117-123
Author(s):  
Vilas P. Kulkarni ◽  
Abhijit S. Rayate ◽  
Cristine Ann Thomas ◽  
Nikhil R. Barhate ◽  
Gaurav J. Gaikwad ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Care Hospital ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Incidence of breast malignancies has been rising. Any breast lump needs to differentiated as surgery may not be required in all cases. The National Health Services Breast Screening Program recommends Fine Needle aspiration cytology (FNAC) as a non-operative diagnostic tool. FNAC is a cheap, readily available, relatively painless, repeatable and patient-friendly investigation with good sensitivity and specificity. FNAC does not yield a tissue diagnosis as opposed to core biopsy, however, a well-performed FNAC and reporting by an expert pathologist help to avoid unnecessary surgeries in benign lesions where only conservative management or elective surgery is needed. Aims: To study the correlation between FNAC and histopathological reports of palpable breast lumps. Materials and method: We conducted an observational study at a tertiary care hospital. The study included 237 patients of palpable breast lumps who had undergone FNAC, excisional biopsy and histopathology in the same institution. The results of FNAC and histopathology reports were correlated into benign and malignant categories. Results: There were 225 women and 12 men in this study. FNAC had reported 20 malignant (C4+C5) cases and 217 benign cases. Histopathology revealed 21 malignant cases and 216 benign cases. We observed a sensitivity of 90.48%, specificity of 99.54%, a positive predictive value of 95%, a negative predictive value of 99.08%, a concordance of 92.41%, a diagnostic accuracy of 98.73% and a negative likelihood ratio of 0.1 for FNAC. Conclusions: Besides other advantages, FNAC of a breast lesion is reliable enough to rule out malignancy.

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