Analysis ofLRRK2,SNCA,andITGA8Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population

Background. Parkinson’s disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors. We performed a case-control study on candidate gene to scrutinize whether genetic variants inLRRK2,SNCA, andITGA8genes could be associated with sporadic PD in Chinese Han population.Methods. Five single-nucleotide polymorphisms (SNPs) ofLRRK2(rs1491942),SNCA(rs2301134, rs2301135, and rs356221), andITGA8(rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls.Results. Rs1491942 ofLRRK2gene had a significantly higher genotype frequency (P=3.543E-09) and allelic G/C frequencies (P=2.601E-10) in PD patients than controls. Rs2301135 ofSNCAgene also showed an obvious difference in genotype frequency (P=4.394E-07) and allelic G/C frequencies (P=9.116E-13) between PD patients and controls. SNPs rs2301134 and rs356221 ofSNCAgene and rs7077361 ofITGA8gene lacked the significant association with the susceptibility of PD in Chinese Han population.Conclusions. Our study firstly expresses that rs1491942 ofLRRK2and rs2301135 ofSNCAgene are substantially associated with sporadic Parkinson’s disease in Chinese Han population.