scholarly journals Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Rong Li ◽  
Xiao-xia Jiang ◽  
Lin-fang Zhang ◽  
Xiao-ming Liu ◽  
Ting-zi Hu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Immune Response ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Type 2 Immunity ◽  
Group 2 ◽  
H Pylori ◽  
Immunosuppressive Microenvironment

H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are promoted by the formation of immunosuppressive microenvironment. But whether group 2 innate lymphoid cells (ILC2s) plays a critical role in H. pylori-induced skewed type 2 immunity is still unclear. In the present study, firstly, we confirmed that type 1 immunity was inhibited and type 2 immunity were undisturbed or promoted after H. pylori infection in vitro and in vivo. Secondly, GATA-3 was firstly found to be increased in the interstitial lymphocytes from H. pylori-associated gastric cancer, among them, Lin−GATA-3+ cells and Lin+GATA-3+ cells were also found to be enhanced, which indicated an important role for ILC2s in H. pylori infection. More importantly, ILC2s were found to be increased after H. pylori infection in clinical patients and animal models. In conclusion, our results indicated that ILC2-mediated innate immune response might play a potential role in dominant type 2 phenotype and immunosuppressive microenvironment in H. pylori infection.

scholarly journals DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells

2021 ◽  
Vol 559 ◽  
pp. 135-140
Author(s):  
Keisuke Matsubara ◽  
Kazufumi Kunimura ◽  
Nana Yamane ◽  
Ryosuke Aihara ◽  
Tetsuya Sakurai ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Type 2 Immunity ◽  
Dock8 Deficiency ◽  
Group 2

scholarly journals Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity

2021 ◽  
Vol 12 ◽  
Author(s):  
Laura Mathä ◽  
Mónica Romera-Hernández ◽  
Catherine A. Steer ◽  
Yi Han Yin ◽  
Mona Orangi ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Eosinophilic Inflammation ◽  
Allergic Lung Inflammation ◽  
Pre Treatment ◽  
Group 2 ◽  
Resident Group ◽  
Type 2 Inflammation

Group 2 innate lymphoid cells (ILC2s) are tissue resident in the lung and activated by inhaled allergens via epithelial-derived alarmins including IL-33. Activated ILC2s proliferate, produce IL-5 and IL-13, and induce eosinophilic inflammation. Here, we report that intranasal IL-33 or the protease allergen papain administration resulted in increased numbers of ILC2s not only in the lung but also in peripheral blood and liver. Analyses of IL-33 treated parabiosis mice showed that the increase in lung ILC2s was due to proliferation of lung resident ILC2s, whereas the increase in liver ILC2s was due to the migration of activated lung ILC2s. Lung-derived ILC2s induced eosinophilic hepatitis and expression of fibrosis-related genes. Intranasal IL-33 pre-treatment also attenuated concanavalin A-induced acute hepatitis and cirrhosis. These results suggest that activated lung resident ILC2s emigrate from the lung, circulate, settle in the liver and promote type 2 inflammation and attenuate type 1 inflammation.

scholarly journals Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

Immunity ◽  
2018 ◽  
Vol 48 (6) ◽  
pp. 1195-1207.e6 ◽  
Author(s):  
Timotheus Y.F. Halim ◽  
Batika M.J. Rana ◽  
Jennifer A. Walker ◽  
Bernhard Kerscher ◽  
Martin D. Knolle ◽  
...  
Keyword(s):  
Costimulatory Molecule ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Type 2 Immunity ◽  
Group 2

scholarly journals MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

Immunity ◽  
2014 ◽  
Vol 41 (2) ◽  
pp. 283-295 ◽  
Author(s):  
Christopher J. Oliphant ◽  
You Yi Hwang ◽  
Jennifer A. Walker ◽  
Maryam Salimi ◽  
See Heng Wong ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Parasitic Helminth ◽  
Type 2 Immunity ◽  
Group 2

scholarly journals Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer?

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3452
Author(s):  
Enrico Maggi ◽  
Irene Veneziani ◽  
Lorenzo Moretta ◽  
Lorenzo Cosmi ◽  
Francesco Annunziato
Keyword(s):  
Immune Response ◽  
Inflammatory Responses ◽  
Cell Subset ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Th2 Cell ◽  
Type 2 Immune Response ◽  
Group 2 ◽  
Lymphoid Organogenesis

Group 2 Innate Lymphoid Cells (ILC2s) belong to the family of helper ILCs which provide host defense against infectious agents, participate in inflammatory responses and mediate lymphoid organogenesis and tissue repair, mainly at the skin and mucosal level. Based on their transcriptional, phenotypic and functional profile, ILC2s mirror the features of the adaptive CD4+ Th2 cell subset, both contributing to the so-called type 2 immune response. Similar to other ILCs, ILC2s are rapidly activated by signals deriving from tissue and/or other tissue-resident immune cells. The biologic activity of ILCs needs to be tightly regulated in order to prevent them from contributing to severe inflammation and damage in several organs. Indeed, ILC2s display both enhancing and regulatory roles in several pathophysiological conditions, including tumors. In this review, we summarize the actual knowledge about ILC2s ability to induce or impair a protective immune response, their pro- or antitumor activity in murine models, human (children and adults) pathologies and the potential strategies to improve cancer immunotherapy by exploiting the features of ILC2s.

T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells

2013 ◽  
Vol 25 (2) ◽  
pp. 139-147 ◽  
Author(s):  
Thomas Hoyler ◽  
Catherine A Connor ◽  
Elina A Kiss ◽  
Andreas Diefenbach
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Type 2 Immunity
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