scholarly journals Domino Liver Transplantation from a Child with Propionic Acidemia to a Child with Idiopathic Fulminant Hepatic Failure

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Marina Moguilevitch ◽  
Ellise Delphin
Keyword(s):  
Liver Transplantation ◽  
Informed Consent ◽  
Liver Transplant ◽  
De Novo ◽  
Propionic Acidemia ◽  
Careful Planning ◽  
Proper Selection ◽  
Domino Liver Transplantation ◽  
Selection Of ◽  
Innovative Concept

Domino liver transplant has emerged as a viable strategy to increase the number of grafts available for transplantation. In the domino transplant organs explanted from one patient are transplanted into another patient. The first successful domino liver transplant was performed in Portugal in 1995. Since then this innovative concept has been applied to several genetic or biochemical disorders that are treated by liver transplantation. An important consideration during this operation is that such livers can pose a risk of the de novo development of the disease in the recipient. That is why this surgical procedure requires careful planning, proper selection of the patients, and informed consent of both donor and recipient.

457 “DE NOVO” AMYLOIDOSIS IN RECIPIENTS OF DOMINO LIVER TRANSPLANTATION: CLINICAL AND HISTOLOGICAL DATA

2010 ◽  
Vol 52 ◽  
pp. S185-S186
Author(s):  
C. Baliellas ◽  
L. Lladó ◽  
C. Casasnovas ◽  
J. Castellote ◽  
J. Fabregat ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
De Novo ◽  
Histological Data ◽  
Domino Liver Transplantation

scholarly journals De Novo Donor Specific Antibody and Long-Term Outcome After Liver Transplantation: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Zahra Beyzaei ◽  
Bita Geramizadeh ◽  
Zahra Bagheri ◽  
Sara Karimzadeh ◽  
Alireza Shojazadeh
Keyword(s):  
Systematic Review ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
De Novo ◽  
Meta Analysis ◽  
Graft Loss ◽  
Cochrane Library ◽  
Long Term Outcome ◽  
The Impact

BackgroundThe impact of de novo anti-HLA donor-specific alloantibodies (DSA) which develop after long-term liver transplantation (LT) remains controversial and unclear. The aim of this study was to investigate the role of de novo DSAs on the outcome in LT.MethodsWe did a systematic review and meta-analysis of observational studies published until Dec 31, 2019, that reported de novo DSA outcome data (≥1 year of follow-up) after liver transplant. A literature search in the MEDLINE/PubMed, EMBASE, Cochrane Library, Scopus and Web of Science Core Collection databases was performed.ResultsOf 5,325 studies identified, 15 fulfilled our inclusion criteria. The studies which reported 2016 liver transplant recipients with de novo DSAs showed an increased complication risk, i.e. graft loss and chronic rejection (OR 3.61; 95% CI 1.94–6.71, P < 0.001; I2 58.19%), and allograft rejection alone (OR 6.43; 95% CI: 3.17–13.04; P < 0.001; I2 49.77%); they were compared to patients without de novo DSAs. The association between de novo DSAs and overall outcome failure was consistent across all subgroups and sensitivity analysis.ConclusionsOur study suggested that de novo DSAs had a significant deleterious impact on the liver transplant risk of rejection. The routine detection of de novo DSAs may be beneficial as noninvasive biomarker-guided risk stratification.

scholarly journals DE NOVO NON-ALCOHOLIC FATTY LIVER DISEASE AFTER LIVER TRANSPLANTATION IN SMALL LIVER TRANSPLANT CENTRE IN SLOVAKIA

2020 ◽  
Vol 104 (S3) ◽  
pp. S487-S488
Author(s):  
Lubomir Skladany ◽  
Svetlana Adamcova Selcanova ◽  
Jana Ciefova ◽  
Natalia Bystrianska ◽  
Beata Skvarkova ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Liver Transplant ◽  
Fatty Liver Disease ◽  
De Novo ◽  
Alcoholic Fatty Liver ◽  
Transplant Centre ◽  
Alcoholic Fatty Liver Disease

No Evidence Of De Novo Amyloidosis In Recipients Of Domino Liver Transplantation: 12 To 40 (Mean 24) Month Follow-Up

Amyloid ◽  
2002 ◽  
Vol 9 (3) ◽  
pp. 194-196 ◽  
Author(s):  
Paulo Lisboa Bittencourt ◽  
Claudia Alves Couto ◽  
Regina Maria Cubero Leitão ◽  
Sheila Aparecida Siqueira ◽  
Alberto Queiroz Farias ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
De Novo ◽  
Domino Liver Transplantation

Clinical symptomatic de novo systemic transthyretin amyloidosis 9 years after domino liver transplantation

2009 ◽  
Vol 16 (1) ◽  
pp. 109-109 ◽  
Author(s):  
Ana Paula Barreiros ◽  
Christian Geber ◽  
Frank Birklein ◽  
Peter R. Galle ◽  
Gerd Otto
Keyword(s):  
Liver Transplantation ◽  
De Novo ◽  
Transthyretin Amyloidosis ◽  
Domino Liver Transplantation

scholarly journals De novo familial amyloidotic polyneuropathy after domino liver transplantation

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S309
Author(s):  
G. Cárdenas ◽  
D. Calatayud ◽  
J. Colmenero ◽  
A. Hessheimer ◽  
J. Núñez ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
De Novo ◽  
Familial Amyloidotic Polyneuropathy ◽  
Domino Liver Transplantation

scholarly journals The concept of “domino” in liver and hepatocyte transplantation

2020 ◽  
Vol 13 ◽  
pp. 175628482096875
Author(s):  
Guang-Peng Zhou ◽  
Li-Ying Sun ◽  
Zhi-Jun Zhu
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Liver Transplant ◽  
Hepatocyte Transplantation ◽  
Transplant Recipients ◽  
Primary Hepatocytes ◽  
The Status ◽  
Domino Liver Transplantation ◽  
End Stage ◽  
Liver Transplant Recipients

Although orthotopic liver transplantation remains the only proven treatment for end-stage liver disease and inherited metabolic liver disease, its application has been limited by the scarcity of donor organs available for transplantation. Among feasible approaches developed to expand the donor organ pool, domino liver transplantation is a strategy in which explanted genetically defective livers of liver transplant recipients are used as grafts in other patients. Another promising therapeutic strategy is hepatocyte transplantation, an alternative to liver transplantation for certain groups of patients. However, the availability of primary hepatocytes is also hindered by the shortage of donor liver tissues. Against this background, domino hepatocyte transplantation, a strategy that utilizes the hepatocytes derived from the explanted livers of liver transplant recipients with noncirrhotic inherited metabolic liver diseases as the source of primary hepatocytes, may help increase the supply of liver cells available for transplantation. In this review, we focus on the status quo of domino liver transplantation and domino hepatocyte transplantation. We also describe recent innovative transplant strategies based on domino transplantation.

Sign in / Sign up

Export Citation Format

Share Document