scholarly journals Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Atsushi Tanaka ◽  
Wataru Saito ◽  
Satoru Kase ◽  
Kan Ishijima ◽  
Kousuke Noda ◽  
...  
Keyword(s):  
Optic Disc ◽  
Surgical Outcomes ◽  
S100 Protein ◽  
Posterior Vitreous Detachment ◽  
Enhanced Depth Imaging ◽  
Protein Markers ◽  
Before And After ◽  
Pars Plana ◽  
Imaging Optical Coherence Tomography ◽  
Optic Disc Anomaly

Purpose. To evaluate the surgical outcomes of pars plana vitrectomy (PPV) with epipapillary membrane removal in patients with maculopathy associated with cavitary optic disc anomalies. Methods. Eight patients (8 eyes) with cavitary optic disc anomaly-associated maculopathy who underwent PPV with epipapillary membrane removal were retrospectively reviewed. The best-corrected visual acuity (BCVA) and macular and papillary morphologies using enhanced depth imaging optical coherence tomography (EDI-OCT) were evaluated before and after treatment. Immunohistochemistry for an intraoperatively excised epipapillary membrane tissue was also performed. Results. Before surgery, EDI-OCT revealed that epipapillary membrane was observed in all patients. Retinoschisis was resolved with no recurrence in all patients following vitrectomy regardless of a disease type or the presence or absence of preoperative posterior vitreous detachment. The mean final BCVA and central retinal thickness significantly improved compared with pretreatment values (P=0.008 and 0.004, resp.). Immunoreactivity for S100 protein and glial fibrillary acidic protein, markers of astrocytes, was positive in the resected membrane tissues. Conclusions. These results suggest that epipapillary membrane is involved in the pathogenesis of some patients with cavitary optic disc anomaly-associated maculopathy as well as posterior hyaloid membrane. PPV with epipapillary membrane removal may be a useful treatment option for this maculopathy. This trial is registered with UMIN000011123.

scholarly journals Changes of Subfoveal Choroidal Thickness after Cataract Surgery: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Shaoxue Zeng ◽  
Chen Liang ◽  
Yueqing He ◽  
Yingying Chen ◽  
Qing Zhao ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Choroidal Thickness ◽  
Meta Analysis ◽  
Enhanced Depth Imaging ◽  
Diabetic Mellitus ◽  
Depth Imaging ◽  
Before And After ◽  
Imaging Optical Coherence Tomography ◽  
Inflammatory Drugs ◽  
Thickness Measurements

Purpose. To investigate the effect of cataract surgery on subfoveal choroid thickness (SFCT) using enhanced-depth imaging optical coherence tomography (EDI-OCT). Materials and Methods. Relevant publications were searched systematically through various databases from inception to March 2018. The unit of choroidal thickness measurements is micrometers. Studies comparing SFCT before and after cataract surgery were retrieved. All qualified articles were analyzed using RevMan 5.3. Results. A total of 13 studies with 802 eyes from 646 patients were identified for inclusion. There was a significant increase of SFCT at 1 week (MD = 6.62, 95% CI: 1.20–12.05, P=0.02, I2 = 0%), 1 month (MD = 8.30, 95% CI: 3.20–13.39, P=0.001, I2 = 0%), and 3 months (MD = 8.28, 95% CI: 1.84–14.73, P=0.01, I2 = 0%) after cataract surgery. In subgroup analysis, SFCT in Asians and patients without nonsteroidal anti-inflammatory drugs (NSAIDs) in postoperative medication was significantly thicker (P<0.05). No statistically significant increase of SFCT was found in diabetic mellitus (DM) patients for 1 day (P=0.89), 1 week (P=0.59), 1 month (P=0.52), and 3 months (P=0.42) after cataract surgery. Conclusions. This meta-analysis suggested that SFCT increased since 1 week after the cataract surgery and the increase lasted for at least 3 months. Asians and patients without NSAIDs in postoperative medication were more likely to have a thicker SFCT after cataract surgery, whereas DM patients were less likely to increase in SFCT.

scholarly journals Inverted ILM flap technique in Optic Disc Pit Maculopathy: An Iranian experience with review of the literature

2021 ◽  
Author(s):  
Ali Tavallali ◽  
Yasaman Sadeghi ◽  
Seyed-Hossein Abtahi ◽  
Hosein Nouri ◽  
Mitra Rezaei ◽  
...  
Keyword(s):  
Optic Disc ◽  
Posterior Vitreous Detachment ◽  
Surgical Techniques ◽  
Case Series ◽  
Internal Limiting Membrane ◽  
Optic Disc Pit ◽  
Review Of The Literature ◽  
Pars Plana ◽  
Optic Disc Pit Maculopathy ◽  
Prospective Case Series

Abstract Purpose To present the outcome of optic disc pit maculopathy (ODPM) managed successfully with inverted internal limiting membrane (ILM) flap over the optic disc. Methods This prospective case series included three patients with ODPM who underwent pars plana vitrectomy with posterior vitreous detachment induction, followed by inverted ILM flap over the optic disc and gas tamponade. Patients were followed for 7-16 weeks as regards their functional and anatomical findings. A narrative review is also provided about Pathology, Pathogenesis, and surgical techniques in the treatment of ODPM Results Three adult patients (25–39 years old) were evaluated, with a mean duration of decreased visual acuity of 7.33 ± 2.40 months (4-12 months). Postoperatively, BCVA improved dramatically in one patient from 2/200 to 20/25. BCVA in the other two improved two and three lines, to 20/50 and 20/30, respectively. Significant anatomic improvement was achieved in all patients. Conclusion Vitrectomy with inverted ILM flap insertion over the optic disc can yield favorable anatomical improvement in patients with ODPM.

Corneal cross-linking for keratoconus: Evaluation of the retina and choroid

2021 ◽  
pp. 112067212110213
Author(s):  
Kobra Nasrollahi ◽  
Fatemeh Razmjoo ◽  
Morteza Naderan ◽  
Alireza Peyman
Keyword(s):  
Choroidal Thickness ◽  
Structural Changes ◽  
Enhanced Depth Imaging ◽  
Cross Linking ◽  
Depth Imaging ◽  
Significant Difference ◽  
Corrected Distance Visual Acuity ◽  
Before And After ◽  
Imaging Optical Coherence Tomography ◽  
Choroidal Volume

Purpose: To investigate the possible structural changes of the central choroid and retina after collagen cross-linking (CXL) in patients with progressive keratoconus (KCN). Methods: Twenty-five eyes of 25 patients were included in this study. Patients underwent enhanced depth imaging optical coherence tomography (EDI-OCT) before and 1 month after CXL. The values for central macular thickness (CMT), subfoveal choroidal thickness (CHT), and choroidal volume (CHV) were evaluated. Results: CMT before and after CXL was 263.24 ± 16.25 μm and 263.20 ± 16.51 μm, respectively ( p = 0.98). CHT was 362.08 ± 36.80 μm and 367.84 ± 33.67 μm before and after CXL, respectively ( p = 0.26). CHV was 8.74 ± 0.33 mm3 and 8.68 ± 0.36 mm3 before and after CXL, respectively ( p = 0.11). There was no significant difference in the corrected distance visual acuity before and after CXL (0.06 ± 0.05 and 0.05 ± 0.05 logMAR, respectively, p = 0.65). Conclusion: Central retinal and choroidal thicknesses are not changed after corneal cross- linking.

scholarly journals A longitudinal study of choroidal changes following cataract surgery in patients with diabetes

2019 ◽  
Vol 16 (4) ◽  
pp. 369-377 ◽  
Author(s):  
Vivien Cherng-Hui Yip ◽  
Augustinus Laude ◽  
Kara Anne Tan ◽  
Jianbin Ding ◽  
Elizabeth Wong ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Choroidal Thickness ◽  
Structural Changes ◽  
Mean Difference ◽  
Enhanced Depth Imaging ◽  
Diabetic Patients ◽  
Depth Imaging ◽  
Before And After ◽  
Patients With Diabetes ◽  
Imaging Optical Coherence Tomography

Objective: To study the structural changes in the choroid of diabetic patients following cataract surgery, using choroidal vascularity index and choroidal thickness. Methods: A prospective case–control study was conducted in 18 diabetic and 18 non-diabetic patients undergoing cataract surgery (phacoemulsification) in one eye. Enhanced depth imaging optical coherence tomography images were obtained before and after surgery. Niblack’s image binarization of images was performed to derive the choroidal vascularity index. Independent sample T-test compared the differences of choroidal vascularity index and choroidal thickness between diabetic and non-diabetic patients. Results: The baseline choroidal vascularity index was significantly lower in diabetic patients for both operated (mean difference vs non-diabetic: 0.0184, 95% CI: 0.004–0.0324, p = 0.012) and non-operated (mean difference vs non-diabetic: 0.0145, 95% CI: 0.003–0.0256, p = 0.012) eyes. Choroidal thickness increased following cataract surgery (diabetes: mean difference = 12.4, 95% CI: 0.70–24.0, adjusted p = 0.036; non-diabetic: mean difference = 21.0, 95% CI: 4.39–37.6, adjusted p = 0.011). Conclusion: Diabetic patients have reduced choroidal vascularity index than non-diabetic patients, suggestive of possible reduction in choroidal vascularity in diabetes. Choroidal thickness increased following cataract surgery in both diabetic and non-diabetic patients.

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