Prediction of Diabetes with Deep Neural Network

Diabetic mellitus is hitting the globe since decades. it often leads to dangerous health issues such as kidney problems, heart strokes, nervous system disturbance and eye problems etc. The prediction and detection of such a deadly disease is pivotal. In the conducted study, we have built a diabetic prediction model which is based on deep neural networks. We performed our experiments with two-fold and four-fold cross validation. Our diabetic prediction model has reported an accuracy of 98.45% which is quite high.

Acceleration time to Ejection time ratio in fetal pulmonary artery system can predict neonatal respiratory disorders in gestational diabetic mellitus women

BACKGROUND: Few researches studied fetal pulmonary pulse wave doppler and the clinical end point disorders in gestational diabetic mellitus (GDM) cohort. OBJECTIVE: To investigate fetal pulmonary artery acceleration time to ejection time ratio (PATET) in the prediction of neonatal respiratory disorders (NRD). METHODS: 238 pregnant women diagnosed with GDM who attended our hospital between February 2018 and March 2020 were retrospectively included. Fetal pulmonary artery Doppler wave measurements were recorded, including main, left and right pulmonary artery blood flow, and left and right peripheral pulmonary artery blood flow. Acceleration time (At)/ejection time (Et) were calculated. RESULTS: 183 GDM pregnant women and neonates were divided into NRD(+)(n = 42) and NRD(–) group (n = 141). 16 cases were neonatal pneumonia (NP) within 28 days after birth in NRD(+) group. The area under curve (AUC) of left peripheral pulmonary artery acceleration time to ejection time (LPPATET) was 0.967 (95% CI: 0.927∼1.000, P < 0.001) and the AUC of right peripheral pulmonary artery acceleration time to ejection time (RPPATET) was 0.967 (95% CI: 0.927∼1.000, P < 0.001), indicating that LPPATET and RPPATET are both predictors for NRD. The results of interobserver variabilty and intraobserver variability showed a good consistency. CONCLUSIONS: The At/Et of fetal peripheral pulmonary artery (PPA) in GDM women may be predictors for NRD, and the indicator can provide assistance in clinical management of diabetes pregnant patients.

Maxillary necrosis by Mucormycosis: A Case Report

A 50-year-old woman with type 2 diabetes was referred to the hospital with a 4-week history of a facial redness that proceeded to significant midface ulceration and bilateral vision loss. Her nasal bridge was completely collapsed, she had naso-palatal ulceration with black eschars on the mucosa, and her fasting blood sugar was significantly increased. Her blood sugar was controlled with soluble insulin through sliding scale, and surgical debridement was performed, which revealed fungal hyphae on histo-pathological assessment. Ketoconazole, an antifungal drug, was commenced immediately. She progressed slowly but steadily after that and her wound became clear with fresh granulation tissue. Keywords: Mucormycosis, Uncontrolled diabetic mellitus

Histochemical Study of Human Placental Tissues in Gestational Diabetic Mellitus

Gestational diabetes mellitus (GDM) is a serious pregnancy complication in which a woman who has never had diabetes develops chronic hyperglycemia during her pregnancy. Normal placental function is essential for optimal fetal growth. The transport of glucose from the mother to the fetus is critical for fetal nutrient demands and can be stored as glycogen in the placenta. However, the function of this glycogen deposition is unknown: It may well be a source of fuel for a placenta itself or the storage reservoir for the later use by the fetus in times of need. While the significance of the placental glycogen remains unknown, the mounting evidence indicates that the altered glycogen metabolism and/or deposition is associated with many pregnancy complications, such as gestational diabetes, that adversely affect fetal development. The aim of this study is to assess glycogen deposition using Histochemical staining of Periodic Acid Schiff (PAS) stain. The placenta tissue collected from 50 women were enrolled in this study (25 women with no complications) and (25 women with gestational diabetes). The placentas of the two groups were compared in this study based on glycogen deposition with periodic acid-Schiff stain. The results of a histochemical investigation using PAS stain revealed a significant increase in the glycogen deposition (p≤0.001) in diabetic women's placentas within the intervillous core, around fetal vessels, and the basement membranes.

Treatment of diabetic neuropathy induced non healing foot ulcer using merisistm supercellplatelet rich fibrin matrix: a clinical study

Objective: Non healing foot ulcers are a major debilitating condition in diabetic patients which leads to limb amputation.In this study we discuss the use ofMERISISTM Supercell plus Platelet Rich Fibrin Matrix (PRFM) kitfor point of care treatments towards limb salvation. Method: We selected diabetic mellitus patients havingDiabetic foot ulcer (DFU) grade 1 or higher. Use of MERISISTM Supercell plus PRFM is a biological matrix of extracellular matrix (ECM) protein plus growth factors derived from peripheral blood to treat the DFU 45 days over. Result: Following treatment the patients showed quick recovery and complete healing of the ulcers. Conclusion: Supercellplus PRFM therapy promotes wound healing in patients suffering from chronic non-healing diabetes foot ulcers. Supercells plus PRFM dressing is a safe and effective treatment modality to promote wound contraction in patients suffering from non-healing diabetic foot ulcers.

Effect of Toxoplasma gondii on Some Physiological Indicators in Women's Patients with Diabetic Mellitus Type 2

Aims: Diabetes mellitus is thought to be caused by infection with the parasite Toxoplasma gondii, although this is still debated, In order to better understand the potential link between toxoplasmosis and diabetes mellitus Study Design: China's prevalence rate of diabetes has been gradually growing in recent years, as a result of the country's rising living standards. Place and Duration of Study: 40 patients who suffer from type 2 diabetes mellitus who were randomly chosen from the Diabetes Mellitus clinic in Al-Sadder Teaching City in Al-Najaf governorate. Methodology: Prior research "on the link between T. gondii infection and diabetes mellitus has been conflicting, we performed matched case-control studies to see whether T. gondii seropositivity is linked" to type 2 diabetes, more research is required. To investigate T. gondii seroprevalence and recognize risk factors and potential transmital pathways of T. gondii infection in type 2 diabetes (T2DM), forty women's blood samples have been gathered and tested for anti-T. gondii IgG, IgM, and SOD. T. gondii seroprevalence in T2DM patients as a whole. Patients' information was collected through a questionnaire that included their age, weight, and blood pressure. Each patient and control participant had five milliliters of venous blood samples collected using a disposable needle and plastic syringes. Results: Patients ranged in age about from (35 to 65) years old. The current investigation was performed on 40 patients who suffer from type 2 diabetes mellitus, Diabetic and T. gondii patientshad a significantly higher compared with control and Diabetic patients only. Also, there were significant differences between patients of diabetic mellitus and control. Conclusion: Blood was permitted to clot for 10 minutes at room temperature before being centrifuged at 6000 rpm for 10 minutes, after which serum was extracted and transferred into fresh disposable tubes. An ELISA test was performed on the blood samples earlier using commercially available kits (EIA-3519 IgG and IgM Germany) and SOD kits.