scholarly journals Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Hyun-Chang Lim ◽  
Daniel S. Thoma ◽  
Mijeong Jeon ◽  
Je-Seon Song ◽  
Sang-Kyou Lee ◽  
...  
Keyword(s):  
Hypoxia Inducible Factor ◽  
Treatment Modalities ◽  
Control Group ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Hypoxia Inducible Factor 1 ◽  
Early Healing ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Apical Area

The aim of the present study was to investigate the effect of hypoxia-inducible factor 1α (HIF1A) on the early healing (4 weeks) of extraction sockets exhibiting partial loss of the labial bone. Two extraction sockets of the maxillary incisors from each of six dogs were assigned to two treatment modalities: deproteinized bovine bone mineral (i) with 10% collagen (DBBM-C) soaked with HIF1A and covered by a collagen membrane (CM) (HIF group) or (ii) treated with DBBM-C only and covered by a CM (control group). Microcomputed tomography revealed some degree of collapse of the labial contour. The totally augmented volume and new bone volume did not differ significantly between two groups (P>0.05). The histological analysis revealed that the apical area of the socket was mostly filled with newly formed bone, while there was less newly formed bone in the coronal area and incomplete cortex formation. The histomorphometric analysis revealed that the area of newly formed bone was significantly larger in the HIF group than the control group (12.16±3.04 versus 9.48±2.01 mm2, P<0.05), while there was no significant intergroup difference in the total augmented area. In conclusion, even though DBBM-C soaked with HIF1A enhanced histomorphometric bone formation, this intervention did not demonstrate superiority in preventing ridge shrinkage compared to DBBM-C alone. Clinical relevance of these findings should be further studied.

scholarly journals Periodontal Responses to Augmented Corticotomy with Collagen Membrane Application during Orthodontic Buccal Tipping in Dogs

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dong-Yeol Lee ◽  
Hyo-Won Ahn ◽  
Yeek Herr ◽  
Young-Hyuk Kwon ◽  
Seong-Hun Kim ◽  
...  
Keyword(s):  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Bone Surface ◽  
Control Side ◽  
Test Side ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Flap Closure ◽  
Deproteinized Bovine Bone

This prospective randomized split-mouth study was performed to examine the effects of absorbable collagen membrane (ACM) application in augmented corticotomy using deproteinized bovine bone mineral (DBBM), during orthodontic buccal tipping movement in the dog. After buccal circumscribing corticotomy and DBBM grafting into the decorticated area, flaps were repositioned and sutured on control sides. ACM was overlaid and secured with membrane tacks, on test sides only, and the flaps were repositioned and sutured. Closed coil springs were used to apply 200 g orthodontic force in the buccolingual direction on the second and third premolars, immediately after primary flap closure. The buccal tipping angles were31.19±14.60° and28.12±11.48° on the control and test sides, respectively. A mean of79.5 ± 16.0% of the buccal bone wall was replaced by new bone on the control side, and on the test side78.9±19.5% was replaced. ACM application promoted an even bone surface. In conclusion, ACM application in augmented corticotomy using DBBM might stimulate periodontal tissue reestablishment, which is useful for rapid orthodontic treatment or guided bone regeneration. In particular, ACM could control the formation of mesenchymal matrix, facilitating an even bone surface.

scholarly journals A clinical and radiographic study of implants placed in autogenous bone grafts covered by either a platelet-rich fibrin membrane or deproteinised bovine bone mineral and a collagen membrane: a pilot randomised controlled clinical trial with a 2-year follow-up

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jens Hartlev ◽  
Søren Schou ◽  
Flemming Isidor ◽  
Sven Erik Nørholt
Keyword(s):  
Survival Rate ◽  
Autogenous Bone ◽  
Control Group ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Bone Level ◽  
Implant Crown ◽  
Marginal Bone Level ◽  
Bovine Bone Mineral

Abstract Purpose To compare the survival and clinical performance of implants placed in sites previously augmented with autogenous bone grafts covered by either a platelet-rich fibrin (PRF) membrane (PRF group) or a standard procedure (gold standard) involving coverage of the autogenous bone graft with deproteinised bovine bone mineral and a resorbable collagen membrane (control group). Methods A total of 27 partially edentulous patients (test n = 14, control n = 13) with indication for staged lateral bone block augmentation and dental implant placement were included. Twenty-four months after crown placement (range: 14–32 months), patients were recalled for a final clinical and radiographic follow-up. Outcome measures were implant survival, implant crown survival, clinical parameters of the implant, peri-implant marginal bone level, marginal bone level of adjacent tooth surfaces, biological and technical complications and patient-related outcome measures. Results Two implants were lost in the control group (85% survival rate); none were lost in the PRF group (100% survival rate). None of the 26 initially placed implant crowns were lost, but one implant and therefore one implant crown were lost after 20 months. Consequently, the definitive implant crown survival was 92% (95% confidence interval (CI): 73–110%) in the control group and 100% in the PRF group. No statistical difference in implant survival rate (p = 0.13) or implant crown survival was seen between the groups (p = 0.28). The mean marginal bone level at the follow-up was 0.26 mm (95% CI: 0.01–0.50 mm) in the PRF group and 0.68 mm (95% CI: 0.41–0.96 mm) in the control group. The difference between the groups was − 0.43 mm (95% CI: − 0.80 to − 0.05 mm, p = 0.03), which was statistically significant (p = 0.03). Both groups demonstrated similar healthy peri-implant soft tissue values at the final follow-up. Conclusion Although the current study is based on a small sample of participants, the findings suggest that the methodology of the PRF and the control group approach can both be used for bone augmentation with a similar outcome. A significant, but clinically irrelevant, higher peri-implant marginal bone level was registered in the PRF group than in the control group. Patients in both groups were highly satisfied with the treatment. Trial registration ClinicalTrials.gov Identifier: NCT04350749. Registered 17 April 2020. Retrospectively registered.

Ridge preservation with the use of deproteinized bovine bone mineral

2013 ◽  
Vol 25 (7) ◽  
pp. 786-790 ◽  
Author(s):  
Jan Lindhe ◽  
Denis Cecchinato ◽  
Mauro Donati ◽  
Cristiano Tomasi ◽  
Birgitta Liljenberg
Keyword(s):  
Bone Mineral ◽  
Ridge Preservation ◽  
Bovine Bone ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Deproteinized Bovine Bone
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