scholarly journals Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Takao Natsuyama ◽  
Yozo Mitsui ◽  
Masato Uetani ◽  
Shigeyuki Ohta ◽  
Masafumi Inoue ◽  
...  
Keyword(s):  
Bladder Neck ◽  
Ileal Conduit ◽  
Neuroendocrine Differentiation ◽  
Urinary Frequency ◽  
Normal Range ◽  
Poorly Differentiated Adenocarcinoma ◽  
History Of ◽  
Poorly Differentiated ◽  
Proximal Urethra ◽  
Enhanced Computed Tomography

We report an extremely rare case of an alpha-fetoprotein- (AFP-) producing female primary urethral adenocarcinoma with neuroendocrine differentiation (NED). The patient was a 65-year-old woman with a 2-year history of urinary frequency and voiding difficulty. Enhanced computed tomography showed an approximately 3.0×5.0-cm mass around the proximal urethra and bladder neck. Of examined tumor markers, serum AFP was elevated (48.3 ng/mL), while others including carcinoembryonic antigen were within a normal range. Transurethral resection of the tumor led to a diagnosis of carcinosarcoma of the urethra, with a radical cystourethrectomy and ileal conduit formation subsequently performed. The pathological assessment was poorly differentiated adenocarcinoma in the urethra. Immunostaining showed tumor cells strongly positive for AFP. In addition, some cancer cells were positive for CD56, chromogranin A, and synaptophysin, indicating focal NED. The tumor was finally diagnosed as an AFP-producing urethral adenocarcinoma with NED. Serum AFP was immediately normalized after surgery and no sign of tumor recurrence has been noted 2 years postoperatively.

Dedifferentiated Liposarcoma With a Paraganglioma-like Histologic Pattern: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (7) ◽  
pp. 788-791
Author(s):  
Dating Liu ◽  
Guillermo Quinonez ◽  
Steven Latosinsky
Keyword(s):  
Neuron Specific Enolase ◽  
Malignant Neoplasm ◽  
Neuroendocrine Differentiation ◽  
Growth Patterns ◽  
Dedifferentiated Liposarcoma ◽  
Tissue Mass ◽  
Histologic Pattern ◽  
History Of ◽  
Poorly Differentiated ◽  
Well Differentiated

Abstract A 53-year-old man presented with a 4-month history of increasing abdominal discomfort and distension. A large retroperitoneal mass was found on imaging. Image-guided needle core biopsy demonstrated a poorly differentiated malignant neoplasm. A 30 × 32 × 33-cm soft tissue mass was removed. Microscopically, the tumor consisted of predominantly epithelioid malignant cells arranged in a paraganglioma-like growth pattern. Immunohistochemically, these cells were strongly positive for neuron-specific enolase. Stains for synaptophysin and chromogranin, however, were negative. There was no ultrastructural evidence of neuroendocrine differentiation. Adjacent sarcomatous areas were composed of spindled cells arranged in storiform and fibrosarcoma-like growth patterns. A small area of well-differentiated liposarcoma was identified, and a diagnosis of dedifferentiated liposarcoma was established. To the best of our knowledge, this represents the first reported case of dedifferentiated liposarcoma with a paraganglioma-like histologic pattern. A brief review focusing on the morphologic variations of dedifferentiated liposarcoma is also presented.

scholarly journals A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

2020 ◽  
Vol 14 (1) ◽  
pp. 186-196
Author(s):  
Ahmed Ahmed ◽  
Umair M. Nasir ◽  
Paul Delle Donna ◽  
Vanessa Swantic ◽  
Shahida Ahmed ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Neuroendocrine Differentiation ◽  
Needle Aspiration ◽  
Gi Tract ◽  
Rare Presentation ◽  
Metastatic Lung ◽  
History Of ◽  
Multiple Blood ◽  
Poorly Differentiated ◽  
Metastatic Lung Carcinoma

Lung cancer is a common malignancy which is frequently found to metastasize to distant sites including bone, liver, and adrenal glands. There are rare reports of metastases to the gastrointestinal (GI) tract, with the duodenum being the most uncommon. We present a rare case of a poorly differentiated lung carcinoma metastasizing to the duodenum. This case enhances the medical literature as it provides additional distinct features to the clinical and histological presentation of metastatic lung carcinoma to the GI tract. A 61-year-old male with a history of poorly differentiated lung carcinoma presented with worsening dizziness, fatigue, and early satiety. He had extensive workup done in the past for hemoptysis including a computerized tomography scan of the chest which showed a new lobulated, apical lesion and hilar lymphadenopathy. He ultimately had a transthoracic fine-needle aspiration (FNA) of the mass and was later diagnosed with poorly differentiated lung carcinoma. On examination, the patient was noted to be pale, tachycardic, and hypotensive. The patient was noted to have an acute drop in his hemoglobin requiring fluid resuscitation, multiple blood transfusions, and evaluation with an esophagogastroduodenoscopy. He was found to have an oozing ulcer in the third portion of the duodenum whose biopsies showed poorly differentiated carcinoma with areas of neuroendocrine differentiation, similar to his lung biopsy results, which was consistent with metastatic lung carcinoma.

scholarly journals A case of Synchronous Malignancy of Stomach and Kidney

2014 ◽  
Vol 11 (1) ◽  
pp. 94-95 ◽  
Author(s):  
S SM Aslam ◽  
H Sridhar ◽  
MY Rao
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Left Kidney ◽  
Poorly Differentiated Adenocarcinoma ◽  
Primary Renal Cell Carcinoma ◽  
History Of ◽  
Poorly Differentiated ◽  
Polypoidal Growth ◽  
Synchronous Malignancy

The synchronous occurrence of primary renal cell carcinoma with gastric cancer is very rare. We report a case of 41 year old male who presented on 05/07/2011 to M S Ramaiah hospital, Bangalore with history of fever, pain abdomen and malena. Ultrasound abdomen and pelvis showed large heterogenous mass arising from the upper pole of left kidney. Computed tomography of the abdomen showed left renal cell carcinoma. Renal biopsy showed features consistent with renal cell carcinoma – clear cell type. Oesophagogastroduodenoscopy revealed gastric polypoidal growth. Gastric biopsy from the growth revealed poorly differentiated adenocarcinoma of stomach. We report this case to highlight a rare occurrence of synchronous malignancy of stomach and kidney. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11053 Kathmandu University Medical Journal Vol.11(1) 2013: 94-95

scholarly journals A case of poorly differentiated adenocarcinoma with neuroendocrine differentiation of the uterine cervix.

1991 ◽  
Vol 30 (6) ◽  
pp. 1193-1198
Author(s):  
Takako KIYOKAWA ◽  
Masakuni FURUSATO ◽  
Hiroshi SASAKI ◽  
Akio TADA ◽  
Kazunori MATUMOTO ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Neuroendocrine Differentiation ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated

Recurrent Intussusception due to Multiple Intestinal Metastases From Lung Adenocarcinoma

2016 ◽  
Vol 101 (11-12) ◽  
pp. 530-534
Author(s):  
Harunobu Sato ◽  
Shinji Ozeki ◽  
Atsuhiko Yoshizawa ◽  
Asako Okabe ◽  
Makoto Kuroda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Needle Biopsy ◽  
Adult Intussusception ◽  
Resected Specimen ◽  
Abdominal Ct ◽  
Poorly Differentiated Adenocarcinoma ◽  
Metastatic Lesions ◽  
History Of ◽  
Poorly Differentiated ◽  
Recurrent Intussusception

Metastasis to the small intestine presents occasionally as multiple lesions and is associated with numerous complications. However, metastasis-induced intussusception in adults is a rare phenomenon. We report a case of recurrent intussusception induced by metastatic lesions from lung cancer. A 54-year-old male was referred to our hospital with intermittent lower right abdominal pain. Chest computed tomography (CT) revealed a mass, suggesting lung cancer, and abdominal CT showed characteristic target-shaped lesions highly suggestive of enteric intussusception in the ileum. The patient underwent segmental resection of the intussuscepted ileum, and analysis of the resected specimen identified a poorly differentiated adenocarcinoma that was pathologically and immunohistologically identical to the lung specimen obtained by percutaneous needle biopsy. Although the symptoms transiently resolved after surgery, intussusception recurred 3 weeks later, and the patient died 28 days after surgery. Multiple metastatic lesions should be considered in adult intussusception, particularly in patients with a history of malignancy.

scholarly journals Bilateral Neuroendocrine Carcinoma of Breast: A Case Report

2021 ◽  
Vol 59 (244) ◽  
pp. 1320-1322
Author(s):  
Sulochana Neupane ◽  
Sanam Dhakal ◽  
Shripad Walawalakar ◽  
Surya Bahadur Parajuli ◽  
Sulav Sapkota
Keyword(s):  
Ductal Carcinoma ◽  
Neuroendocrine Differentiation ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Breast Cancers ◽  
Breast Carcinomas ◽  
Breast Lump ◽  
History Of ◽  
Poorly Differentiated ◽  
Neuroendocrine Carcinomas

Primary neuroendocrine carcinomas of the breast are rare of all breast carcinomas. They may be welldifferentiated, poorly differentiated, or invasive breast cancers with neuroendocrine differentiation. They are staged and treated similarly to conventional breast cancer. Herein, we report a case of invasive ductal carcinoma with neuroendocrine differentiation of the breast in a 73 years female with a history of breast lump initially in the lower inner quadrant of left breast and a month later, similar lump at the same site in right breast. Patient underwent Modified Radical Mastectomy bilaterally followed by adjuvant chemotherapy based on Carboplatin and Etoposide regimen.

scholarly journals Eyelid Abscess with Dacryocystitis due to Burkholderia pseudomallei

2020 ◽  
pp. 61
Author(s):  
Chee Yik Chang
Keyword(s):  
Burkholderia Pseudomallei ◽  
White Cell Count ◽  
Lower Eyelid ◽  
Nasolacrimal Duct ◽  
Normal Range ◽  
Abdominal Ultrasonography ◽  
Skin Erythema ◽  
History Of ◽  
The Right ◽  
Enhanced Computed Tomography

A 24-year-old female complained of a 2-week history of fever and right-eye swelling. There was no ocular pain, blurring of vision, or history of prior trauma to the affected eye. On examination, she was febrile and not in respiratory distress. The right lower eyelid appeared swollen with skin erythema (Figure 1), while the visual acuity was normal. The white cell count was 14.8 × 103/μL (normal range = 4 – 10 × 103/μL). Her liver and renal function tests were within the normal range. The abdominal ultrasonography revealed multiple splenic microabscesses, while chest radiograph was normal. Contrast-enhanced computed tomography of the orbit showed a right lower eyelid abscess with extension into the right nasolacrimal duct (Figure 2). Incision and drainage of the eyelid abscess were performed and the culture of the pus, as well as the blood, yielded Burkholderia pseudomallei. She received intravenous ceftazidime 2 g every 8 hours for 4 weeks, followed by oral trimethoprim-sulfamethoxazole for 20 weeks’ duration. The right eyelid abscess and splenic microabscesses resolved completely post-treatment. Please interpret the figures and suggest the provisional diagnosis.

scholarly journals Fluoroscopy-guided balloon dilation of a proximal urethral stricture caused by a urethral membrane in a female cat

2019 ◽  
Vol 5 (2) ◽  
pp. 205511691986717
Author(s):  
Javier Rincon Alvarez ◽  
Victoria Smith ◽  
Cameron Broome
Keyword(s):  
Urinary Incontinence ◽  
Urethral Stricture ◽  
Bladder Neck ◽  
Balloon Dilation ◽  
Clinical Signs ◽  
Excellent Outcome ◽  
Case Summary ◽  
Retrograde Urethrogram ◽  
History Of ◽  
Proximal Urethra

Case summary A proximal urethral stricture was diagnosed by retrograde urethrogram in a 2-year-old female neutered cat, which was referred following a 2-month history of stranguria, pollakiuria and urinary incontinence. Cystoscopic examination confirmed the presence of a severe narrowing of the proximal urethra near to the bladder neck, consisting of a membrane arising from the urethral mucosa. Fluoroscopy-guided balloon dilation was performed. Twelve months after the procedure, the cat did not show any recurrence of clinical signs. Relevance and novel information To our knowledge, this is the first report of a proximal urethral stricture in a cat. Management by fluoroscopy-guided balloon dilation proved to be a successful and minimally invasive option with an excellent outcome.

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