scholarly journals Effects of SMILE Surgery on Intraocular Pressure, Central Corneal Thickness, Axial Length, Peripapillary Retinal Nerve Fiber Layer, and Macular Ganglion Cell Complex Thickness

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Zhanlin Zhao ◽  
Sylvain Michée ◽  
Jean-François Faure ◽  
Christophe Baudouin ◽  
Antoine Labbé
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Axial Length ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean

Purpose. To evaluate the change in intraocular pressure (IOP), central corneal thickness (CCT), axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular ganglion cell complex (GCC) thickness after small incision lenticule extraction (SMILE) surgery. Methods. This prospective observational study was conducted in Espace Nouvelle Vision, Ophthalmological Clinic, Paris, France. Fifty eyes of 25 patients were enrolled in this study and underwent SMILE surgeries. IOP, central corneal thickness (CCT), axial length (AL), peripapillary RNFL thickness, and macular GCC thickness were measured before and at 3 months after SMILE. Results. The mean preoperative spherical equivalent was −3.15 ± 1.50 diopters (D), and the mean postoperative value was 0.15 ± 0.28 D. After SMILE surgery, IOP decreased from 15.03 ± 2.79 mmHg to 11.02 ± 2.73 mmHg and 10.02 ± 2.21 mmHg at 1 and 3 months, respectively ( P < 0.01 for both comparisons). The mean decrease in measured IOP as a function of ablation depth was 0.065 ± 0.031 mmHg/μm. CCT decreased from 545.98 ± 26.61 μm to 478.40 ± 30.26 μm after SMILE surgery ( P < 0.01 ). AL decreased from 24.80 ± 0.84 mm to 24.70 ± 0.83 mm ( P < 0.01 ). There was no statistically significant change in mean peripapillary RNFL or mean GCC thickness after SMILE surgery. Conclusions. SMILE surgery modified IOP measurement, CCT, and AL but did not change peripapillary RNFL and macular GCC thicknesses. The postoperative drop in measured IOP might be explained by the decreased CCT. An accurate re-evaluation of AL should be performed before cataract surgery among post-SMILE patients.

scholarly journals Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Shih-Chun Chao ◽  
Shang-Jung Yang ◽  
Hung-Chi Chen ◽  
Chi-Chin Sun ◽  
Chin-Hsin Liu ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Control Group ◽  
Ganglion Cell Complex ◽  
Outer Retina ◽  
Flow Area

Purpose. To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods. A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. The ophthalmic data including best-corrected visual acuity, spherical equivalent, intraocular pressure, central corneal thickness, central foveal thickness, visual field deviation, retinal nerve fiber layers thickness, and ganglion cell complex thickness were obtained from medical documents. For the macular area, the superficial vessel density (VD), deep VD, foveal avascular zone (FAZ), flow area of the outer retina, and flow area of the choriocapillaris were measured via OCTA and analyzed using the default vascular density analysis program in the same OCTA device. Results. A total of 70 eyes from 70 patients were analyzed in the current study. Significant differences in the intraocular pressure, central corneal thickness, visual field deviation, retinal fiber layer thickness, and ganglion cell complex thickness were observed in the patients in the glaucoma group at their last visits. The OAG and NTG groups evinced a lower superficial VD than did the control group, while the NTG group had a lower deep VD than the control group. The NTG group also had a larger FAZ than did the OHT group. The flow area of the outer retina in the OAG group was low relative to those of the OHT and control groups. No difference in choriocapillaris perfusion was observed among the groups. Conclusion. The OAG and NTG patients demonstrated impaired vasculature before significant disease development could be observed. Furthermore, the differences in macular circulation may be associated with differences in the courses of disease between the glaucoma and OHT patients.

scholarly journals Effects of testosterone on intraocular pressure, thickness of retinal nerve fiber layer, ganglion cell complex, macula and on ocular blood flow in female-to-male transgender persons

2021 ◽  
Author(s):  
Oksan Alpogan ◽  
Emin Erhan Donmez ◽  
Ayşe Özlem Balık ◽  
Fisun Vural ◽  
Gizem Kaplan
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ocular Blood Flow ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Group 3 ◽  
Group 2

Abstract PurposeTo compare the effects of testosterone on intraocular pressure (IOP), retinal nerve fiber layer thickness (RNFL), ganglion cell complex (GCC), macular thickness (MT), and ocular blood flow between female-to-male transgender (FMT) persons who use testosterone and healthy women and healthy men.MethodThe study included 39 eyes of 20 FMT(group 1), 40 eyes of 20 healthy women (group 2), and 42 eyes of 21 healthy men (group 3). In all subjects, RNFL, GCC, MT were measured by optical coherence tomography (OCT). Ocular blood flow was measured by Colour Doppler Ultrasonography in all subjects.ResultsIOP levels in FMT were significantly higher than men (p = 0.02). Para superior (Sup), Para inferior (Inf) and Peri nasal (Nas) thickness in FMT were significantly higher than the group 2 (p = 0.02, p = 0.03, p = 0.01). Peri Sup thickness in FMT was significantly higher than group 3 (p = 0.01). Peri Inf thickness in FMT was significantly higher than group 2 and 3 (p = 0.03, p = 0.002). Mean thickness of RNFL Inf in FMT was significantly higher than the group 2 and 3 (p = 0.03, p = 0.03). Avg GCC, Inf GCC in FMT were significantly higher than group 2 (p = 0.02, p = 0.005). In correlation test, systole/diastole ratio(S/D) in Ophthalmic artery (OA) (r = 0.504, p = 0.028) and Inf RNLF thickness (r = 0.485, p = 0.035) were positively correlated with the serum levels of testosterone in FMT.ConclusionsWe found that the use of supraphysiologic testosterone dose increased IOP and the thickness of macula, RNFL and GCC in FMT. Serum testosterone level was positively correlated with S/D ratio in the OA.

scholarly journals Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using optical coherence tomography

2020 ◽  
Author(s):  
Panitha Jindahra ◽  
Nitchanan Hengsiri ◽  
Pirada Witoonpanich ◽  
Anuchit Poonyathalang ◽  
Teeratorn Pulkes ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean

Abstract Background: To evaluate the feasibility of using optical coherence tomography (OCT) for the detection of Alzheimer's disease (AD), by measuring the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer and inner plexiform layer (GCL-IPL).Methods: This was a single-center, cross-sectional study. The study included 29 patients with AD (mean age ± standard deviation: 75.61 ± 6.24 years) and 29 healthy age- and sex-matched controls. All participants underwent cognitive evaluations using the Montreal Cognitive Assessment test. Measurements of the RNFL thickness, as well as GCL-IPL thickness, were obtained for all participants using OCT. Both RNFL and GCL-IPL parameters were adjusted for best–corrected visual acuity.Results: The mean RNFL thickness was significantly thinner in the AD group than in the control group (85.24 and 90.68 µm, respectively, adjusted P = 0.019). The superior quadrant was thinner in the AD group (adjusted P = 0.042). The thicknesses did not differ significantly between groups for the other quadrants. The mean GCL-IPL thickness in the AD (68.81 µm) was significantly thinner than that in the controls (76.42 µm) (adjusted P = 0.010). Overall, there was a negative correlation between age and mean RNFL; and between age and GCL-IPL thickness (r = − 0.338, P = 0.010 and r = − 0.346, P = 0.008, respectively).Conclusions: The mean RNFL and GCL-IPL thicknesses were thinner in the AD group than in the control group. These findings suggest that RNFL and GCL-IPL thickness may be biological markers for AD.

scholarly journals Does Septorhinoplasty-Related Periorbital Edema Affect Intraocular Pressure and Retina?

2019 ◽  
pp. 014556131987573
Author(s):  
Oğuzhan Dikici ◽  
Süay Özmen ◽  
Gülçin Kazaz Dikici ◽  
Nuray Bayar Muluk ◽  
Çağla Çapkur Akkuzu
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Complex ◽  
Open Rhinoplasty ◽  
Periorbital Edema ◽  
Fiber Layer ◽  
Nerve Fiber Layer

Background: Open rhinoplasty has been performed for over 50 years. Rhinoplasty procedures have a risk of complications and it is important to follow each step diligently in order to avoid complications. Periorbital edema is the most common complication of septorhinoplasty. As far as we are aware, there are no studies in the available literature examining the impact of the septorhinoplasty on intraocular pressure and the retina. Objectives: The aim of this study was to evaluate the effects of septorhinoplasty-related periorbital edema on intraocular pressure and the retina by means of objective tests. Methods: Ten patients with phase 4 periorbital edema (5 males and 5 females) who underwent open rhinoplasty with bilateral lateral osteotomies were enrolled in the study. All the patients were examined by an eye specialist for visual acuity, intraocular pressure, retinal nerve fiber layer, and ganglion cell complex pathologies with optical coherence tomography preoperatively and postoperatively on the seventh day. Results: Preoperative and postoperative best-corrected visual acuity; intraocular pressure; average, superior, and inferior retinal nerve fiber layer thickness; and total, superior, and inferior ganglion cell complex thickness in both eyes for all patients were within normal limits. There was no statistical difference between preoperative and postoperative values ( P > .05). Conclusion: We concluded that periorbital edema after septorhinoplasty causes no significant complications affecting intraocular pressure and visual acuity. We believe that when osteotomies and local anesthetic injections are undertaken correctly, periorbital complications do not affect vision.

Effects of fasting on peripapillary capillary density, peripapillary nerve fiber layer, intraocular pressure and central corneal thickness

2020 ◽  
Vol 40 (6) ◽  
pp. 1439-1447 ◽  
Author(s):  
Naveed Nilforushan ◽  
Navid Abolfathzadeh ◽  
Mohammad Banifatemi ◽  
Arezoo Miraftabi ◽  
Mahsa Sardarinia ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Nerve Fiber ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Capillary Density ◽  
Fiber Layer ◽  
Nerve Fiber Layer
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