scholarly journals Correlation between the Nonperfusion Area on Ultra-Widefield Fluorescein Angiography and Nonflow Area on Optical Coherence Tomographic Angiography in Retinal Vein Occlusion

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jianfeng Huang ◽  
Yingyi Lu ◽  
Xiaoya Gu ◽  
Bodi Zheng ◽  
Tong Chen
Keyword(s):  
Fluorescein Angiography ◽  
Retinal Vein Occlusion ◽  
Statistical Testing ◽  
Foveal Avascular Zone ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Vein Occlusion ◽  
Capillary Plexus ◽  
Temporal Quadrant ◽  
Tomographic Angiography

Aims. To compare the relationship between the nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFFA) and the nonflow area (NFA) on optical coherence tomographic angiography (OCTA) in retinal vein occlusion (RVO). Methods. Cross-sectional study. 46 eyes of 46 RVO patients who underwent UWFFA and OCTA. NPA and ischemic index (ISI) were quantified on UWWFA. NFA, vessel density (VD) of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the size foveal avascular zone (FAZ) on 3 ∗ 3 mm OCTA were measured. The association of the NPA and ISI on UWWFA and the parameters on OCTA were analyzed. Spearman correlation was used for statistical testing. Results. The NPA and ISI on UWFFA were significantly correlated with the NFA on OCTA in RVO, and r values were 0.688 ( p < 0.01 ) and 0.680 ( p < 0.01 ), respectively. VD in the SCP of the temporal quadrant was negatively correlated with NPA and ISI, and r values were −0.346 ( p < 0.05 ) and −0.337 ( p < 0.05 ), respectively. VD in the DCP of the temporal quadrant was negatively correlated with the NPA, and the r value was −0.246 ( p < 0.05 ). No significant correlation was found between the NPA and ISI on UWFFA and VD of other quadrants in the SCP or DCP and the FAZ area on OCTA. Conclusion. NPA in the peripheral retina was correlated with NFA in macula. NFA detected by OCTA could be an indicator of the ischemic status in RVO.

Fundus Fluorescein Angiography, Optical Coherence Tomography, and Optical Coherence Tomography Angiography Findings in Branch Retinal Vein Occlusion

2019 ◽  
pp. 83-87
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Optical Coherence Tomography Angiography ◽  
Serous Retinal Detachment ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Vein Occlusion ◽  
Capillary Plexus

Even though the diagnosis depends on clinical examination, in cases with branch retinal vein occlusion (BRVO), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) provide unique data for follow-up, management and prognosis. In FFA, delay of laminar flow phase in the involved branch, hyperfluorescence due to leakage from the vessel wall in the late phases, hypofluorescence due to the blockage by hemorrhage, and soft exudates, and hyperfluorescence due to macular edema can be detected. In OCT, macular thickening, cystic spaces, serous retinal detachment, hyperreflective dots, disorganization of the outer retinal layers – particularly the photoreceptor inner and outer segments line and the external limiting membrane – can be seen. OCTA reveals non-perfusion, particularly in the deep capillary plexus.

Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Correlation between Foveal Avascular Zone Area and Visual Acuity

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Lubna Feroz ◽  
Najia Uzair ◽  
Mariam Shamim ◽  
Shahab ul Hassan Siddiqui ◽  
Syed Asad Mehmood
Keyword(s):  
Visual Acuity ◽  
Observational Study ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Foveal Avascular Zone ◽  
P Value ◽  
Optical Coherence ◽  
Vein Occlusion ◽  
Avascular Zone ◽  
Capillary Plexus

Purpose:  To find out correlation between visual acuity and deep capillary plexus (DCP) in foveal avascular zone (FAZ) area using OCTA in patients with retinal vein occlusion (RVO). Study Design:  Descriptive observational study. Place and Duration of Study:  Layton Rehmatullah Benevolent trust free Eye Hospital, from September 2018 to December 2019. Methods:  This observational study included 50 eyes of 50 patients, who were treated with intra-vitreal anti-VEGF for macular edema secondary to retinal vein occlusion. We excluded patients with macular edema due to other ocular diseases. OCTA was performed in every patient to measure the size of foveal avascular zone. FAZ area of 0.6mm2 or less was taken as normal and any value above that was considered to be larger FAZ. IBM SPSS version 25 was used to analyze the data. Frequencies with percentages were used to present qualitative variables and mean ± SD were calculated for the quantitative variables. P-value ? 0.005 was taken as significant. Results:  Mean age was 58.38 ± 7.51 years. There were 28 males and 22 females. Mean best-corrected visual acuity was 0.62 ± 0.26 logMar. The patients with normal FAZ area in DCP showed a mean BCVA of 0.51 ± 0.265 logMAR in comparison to those who had larger FAZ in DCP, where the mean BCVA was 0.75 ± 0.204 logMAR. DCP was larger in patients with CRVO than BRVO. Conclusion:  OCTA is a good diagnostic tool for qualitative and quantitative evaluation of the deep capillary plexus. Improvement in visual acuity is related with the size of the DCP in FAZ. Key Words:  Retinal vein occlusion, Foveal avascular zone, Optical Coherence Tomograghy Angiography.

scholarly journals Fluorescein angiography, optic coherence tomography, and optic coherence tomography angiography in central retinal vein occlusion and macular edema

2019 ◽  
pp. 21-25
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Circulation System ◽  
Optic Coherence Tomography ◽  
Optical Coherence ◽  
Vein Occlusion ◽  
Central Retinal Vein

Retinal vein occlusion (RVO) is one of the most common retinal vascular diseases. Macular edema (ME) is the most common reason for decreased visual acuity in RVO. Macular edema results from disruption of the blood-retinal barrier and subsequent accumulation of the leaking fluid leading to increased retinal thickness. Fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) are commonly used for the diagnosis of macular edema. FFA identifies the anatomical location and pattern of vascular leakage and shows the retinal blood circulation system. OCT allows us to describe the morphological characteristics of macular edema and also to monitor the treatment response of ME to different drugs. Optical coherence tomography angiography (OCTA) is a new method that can visualize the vascular networks in separate layers of the retina in the macular region. In this paper, the authors aimed to review the evaluation of these three tests in ME secondary to central retinal vein occlusion (CRVO).

scholarly journals Characterization of microvascular tortuosity in retinal vein occlusion utilizing optical coherence tomography angiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hyungwoo Lee ◽  
Myung Ae Kim ◽  
Hyung Chan Kim ◽  
Hyewon Chung
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Vein Occlusion ◽  
Optical Coherence Tomography Angiography ◽  
Branch Length ◽  
Optical Coherence ◽  
Branch Number ◽  
Affected Area ◽  
Vein Occlusion ◽  
Capillary Plexus

Abstract We investigated the characteristics of microvessel tortuosity in branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) and their associations with visual outcomes using optical coherence tomography angiography (OCTA). Thirty-four BRVO and 21 CRVO patients and 31 healthy subjects were included. From OCTA, the branch number (BN), mean branch length (BL), mean Euclidean length (EL), vessel density (VD) and vessel tortuosity (VT) were quantified. In BRVO eyes, compared with that in the controls, the affected area of the deep capillary plexus (DCP) showed a decreased BN and VD, an increased BL, and unchanged VT. The nonaffected area of the DCP showed decreases in BN, VD and VT. The affected area of the superficial capillary plexus (SCP) showed higher VT. In CRVO eyes, the DCP showed a lower BN, VD and VT, while the SCP showed a lower BN and greater BL and EL. Improved visual acuity (VA) after 1 year in BRVO eyes was associated with decreases in BN, BL, VD and VT in the affected area in the DCP and lower VT in the nonaffected area of the SCP; in CRVO eyes, improved VA was associated with a higher BL and EL in the DCP. VT, BL, and EL may be new microvascular markers associated with changes in VA in BRVO and CRVO.

scholarly journals Diagnostic value OF oct-angiography AND regional hemodynamic assesSment in patients with retinal vein occlusion

2017 ◽  
Vol 10 (2) ◽  
pp. 40-48 ◽  
Author(s):  
Svetlana N Tultseva ◽  
Yury S Astakhov ◽  
Aleksey G Rukhovets ◽  
Aleksandra I Titarenko
Keyword(s):  
Retinal Vein Occlusion ◽  
Vision Loss ◽  
Comprehensive Evaluation ◽  
Oct Angiography ◽  
Foveal Avascular Zone ◽  
Capillary Perfusion ◽  
Flow Area ◽  
Vein Occlusion ◽  
Hemodynamic Assessment ◽  
Capillary Plexus

Introduction. Ischemic maculopathy is the main cause of irreversible vision loss due to retinal vein occlusion (RVO). Fluorescent angiography (FA), being “golden standard” in evaluating retinal capillary plexus does not allow to visualize separately intraretinal capillary networks. Optical coherence tomography angiography (OCT-angiography) gives the possibility to visualize 4 capillary plexi and allows carrying out a quantitative analysis of microcirculation quantitatively estimating capillary network density and non-perfusion areas. Aim: to investigate microcirculation changes using OCT-angiography data and to compare them to opthalmoplethysmography indices in patients with RVO. Material and methods: The study included 12 patients with retinal vein occlusion. In all patients, routine ophthalmic examination was carried out, and additionally ocular blood flow was estimated using FA, OCT-angiography and ophthalmoplethysmography. Results: Ischemia in the macular area was detected in 4 patients (25%) according to FA results, and in 8 (67%) according to OCT-angiography data. In comparison with the unaffected eye, significant decrease in density of both superficial and deep capillary plexi, decrease in ‘flow area’ and enlargement of foveal avascular zone were observed. Significant close direct correlation was established between capillary density in the superficial capillary plexus (r > 0.8) and the deep one (r > 0.7), choroidal thickness, and opthalmoplethysmography indices (r > 0.6). Conclusion: When compared to FA, OCT-angiography is a more sensitive method to detect macular capillary perfusion. In case of retinal veins occlusion the combination of the above mentioned methods with ophthalmoplethysmography allows to perform comprehensive evaluation of the regional hemodynamics.

scholarly journals Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy

2019 ◽  
pp. bjophthalmol-2019-315358 ◽  
Author(s):  
Yong Luo ◽  
Jianbo Wan ◽  
Chang Luo ◽  
HengWei Liu ◽  
YuFan Zhou ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Retinal Vein Occlusion ◽  
Aqueous Humour ◽  
Pearson Correlation ◽  
Vein Occlusion ◽  
Pearson Correlation Test ◽  
Capillary Plexus ◽  
Colour Photography ◽  
Tomographic Angiography ◽  
The Relationship

PurposeTo investigate the levels of matrix metalloproteinases (MMPs) in aqueous humour of patients with retinal vein occlusion (RVO) and the relationship between intraocular MMP levels and retinal lesion and visual prognosis.Materials and methods52 RVO patients, including 23 with central retinal vein occlusion (CRVO) and 29 with branch retinal vein occlusion (BRVO) and 20 participants with senile cataract were enrolled in this study. Retinal lesions were examined by fundus colour photography, fluorescein fundus angiography and optical coherence tomographic angiography. Sixty microliters of aqueous humour were collected during intravitreal anti-Vascular Endothelial Growth Factor (VEGF) injection or cataract surgery. The aqueous levels of MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10 were measured using the Luminex xMAP multiplex assay. The relationship between MMP levels and clinical presentations was analysed by Pearson correlation test.ResultsThe aqueous humour levels of MMP-1, MMP-2, MMP-7 and MMP-9, but not MMP10 in RVO patients were significantly higher than those in people with cataract after adjusting for age. Further analysis of RVO subgroups showed that the aqueous humour level of MMP2 in CRVO was significantly higher than that in BRVO. The aqueous humour levels of MMP-1 and MMP-2 were positively correlated with superficial capillary plexus vessel density (SVD), whereas the aqueous humour levels of MMP-1 and MMP-7 were negatively correlated with visual improvement following treatment. No correlation between aqueous humour levels of MMP and disease duration and central retinal thickness was observed.ConclusionsRVO eyes had significantly higher intraocular levels of MMP-1, MMP-2, MMP-7 and MMP-9 than cataract eyes and the level of MMP2 appears to be related to the area of occlusion. Intraocular levels of MMP may positively affect SVD and negatively impact visual function in RVO.

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