scholarly journals Highest Recorded Serum Creatinine

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Christine Persaud ◽  
Uttsav Sandesara ◽  
Victor Hoang ◽  
Joshua Tate ◽  
Wayne Latack ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Deceased Donor ◽  
Extensive Literature ◽  
Uremic Patient ◽  
Deceased Donor Kidney ◽  
Periodic Monitoring ◽  
Risk Patients ◽  
History Of ◽  
Renal Allograft Failure ◽  
Deceased Donor Kidney Transplant

Serum creatinine is a commonly used laboratory marker to assess kidney function; however, there has not been an established level of serum creatinine to predict mortality. After extensive literature review, we present a case of the highest recorded serum creatinine of 73.8 mg/dL in a 23-year-old male with the history of pediatric deceased donor kidney transplant (DDKT). He initially presented with uremia and signs of acute renal allograft failure after two months of immunosuppressive medication nonadherence, ultimately requiring emergent hemodialysis, which was complicated by new onset seizures. This was the patient’s fourth episode of late acute rejection and emphasizes the need for education of immunosuppressant adherence and periodic monitoring of renal function in high-risk patients. Though there is no known creatinine level incompatible with life, this patient appears to have the highest known serum creatinine in a uremic patient on record.

P1728FUROSEMIDE STRESS TEST PREDICTS DISCHARGE SERUM CREATININE AFTER KIDNEY TRANSPLANTATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Armando Coca ◽  
Guadalupe Tabernero ◽  
Carlos Arias-Cabrales ◽  
Jimmy Reinaldo Sanchez Gil ◽  
Jose Antonio Menacho Miguel ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Serum Creatinine ◽  
Stress Test ◽  
Graft Function ◽  
Deceased Donor ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Donor Kidney ◽  
Deceased Donor Kidney ◽  
Deceased Donor Kidney Transplant

Abstract Background and Aims Acute tubular necrosis is a common complication after kidney transplantation and is closely related to delayed graft function (DGF) and slower graft function recovery after surgery. The furosemide stress test (FST) uses a standardized dose of furosemide to evaluate the integrity of the renal tubule and determine which patients have developed severe tubular damage. We aimed to apply the FST to a sample of incident deceased-donor kidney transplant recipients and describe its association with DGF and serum creatinine (SCr) at discharge. Method Single-center prospective observational study of deceased-donor kidney transplant recipients. The FST, a standardized bolus dose of furosemide (1.5 mg/kg) was administered between the 3rd and 5th day after surgery. Patients were excluded if, during that time period, they presented evidence of active bleeding, obstructive uropathy or volume depletion. Urine output (UO) 60 and 120 min after FST was registered. To reduce the risk of hypovolemia, each ml of UO produced for six hours after FST was replaced with 1 ml of normal saline. Results 25 patients were included in the study. Mean 2h FST UO was 1012±570 ml. Demographic and clinical data are summarized in Table 1. Subjects that suffered DGF had a significantly lower 2h FST UO (534 vs 1164 ml; P=0.015). In adjusted linear regression analysis only a 2h FST UO<1000 ml (β=0.906; 95%CI: 0.04-1.772; P=0.041) and DGF (β=1.592; 95%CI: 0.488-2.696; P=0.008) were independent predictors of SCr at discharge (model adjusted for recipient age, cold ischemia time, number of HLA mismatches, donor SCr and donor hypertension). Conclusion Recipients with a 2h FST UO <1000 ml suffered DGF more frequently. FST and DGF were independent predictors of SCr at discharge. A standardized FST could help clinicians distinguish patients with more severe tubular dysfunction and higher risk of DGF.

Utility and safety of early allograft biopsy in adult deceased donor kidney transplant recipients

2019 ◽  
Vol 24 (4) ◽  
pp. 356-368 ◽  
Author(s):  
Evaldo Favi ◽  
Ajith James ◽  
Carmelo Puliatti ◽  
Phil Whatling ◽  
Mariano Ferraresso ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Deceased Donor ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Donor Kidney ◽  
Allograft Biopsy ◽  
Deceased Donor Kidney ◽  
Deceased Donor Kidney Transplant

scholarly journals Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Elizabeth Abou Diwan ◽  
Ankit B. Patel ◽  
Alex G. Cuenca ◽  
Nahel Elias ◽  
Hannah M. Gilligan ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Short Bowel Syndrome ◽  
Kidney Transplant Recipient ◽  
Deceased Donor ◽  
Volume Depletion ◽  
Short Bowel ◽  
Deceased Donor Kidney ◽  
Deceased Donor Kidney Transplant ◽  
First Time

Among patients with short bowel syndrome who commonly have kidney disease, kidney transplantation remains challenging. We describe the clinicopathologic course of a 59-year old man with short bowel syndrome secondary to Crohn’s disease who underwent a deceased donor kidney transplant that was complicated by recurrent acute kidney allograft injury due to volume depletion from diarrhea, ultimately requiring the placement of permanent intravenous access for daily volume expansion at home resulting in the recovery of allograft function. Teduglutide treatment at 1.8 years post-transplant led to a dramatic decrease in diarrhea. A literature review of similar cases yielded 18 patients who underwent 19 kidney transplants. Despite high rates of complications, at the time of last follow-up (median 2.1 years [0.04-7]), 94% of the patients were still alive and 89% had functioning allografts, with a median eGFR of 37.5 [14-122] ml/min/1.73m2. In conclusion, despite high rates of complications, kidney transplantation in patients with short bowel syndrome is associated with acceptable short- and midterm outcomes. Further, we report for the first time the effects of the glucagon-like peptide-2 analogue teduglutide for short bowel syndrome in a kidney transplant recipient.

scholarly journals Pre-emptive deceased-donor kidney transplant: A matched cohort study

2020 ◽  
Vol 40 (1) ◽  
pp. 32-37
Author(s):  
Antonio Franco ◽  
Patricio Más-Serrano ◽  
Yussel González ◽  
Noelia Balibrea ◽  
David Rodríguez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplant ◽  
Deceased Donor ◽  
Matched Cohort ◽  
Donor Kidney ◽  
Matched Cohort Study ◽  
Deceased Donor Kidney ◽  
Deceased Donor Kidney Transplant
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