scholarly journals Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Mojgan Sanjari ◽  
Mohammadreza Shakibi ◽  
Moeinadin Safavi
Keyword(s):  
Clinical Manifestations ◽  
Skin Lesions ◽  
Small Vessel Vasculitis ◽  
Iga Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Cutaneous Lesions ◽  
Radioiodine Ablation ◽  
Antithyroid Agents ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Graves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch–Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch–Schönlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch–Schönlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch–Schönlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient.

IgA Cutaneous Purpura Post–Renal Transplantation in a Patient With Long-Standing IgA Nephropathy

2015 ◽  
Vol 19 (5) ◽  
pp. 498-503 ◽  
Author(s):  
Bahman Sotoodian ◽  
Janet Robert ◽  
Muhammad N. Mahmood ◽  
Elaine Yacyshyn
Keyword(s):  
Renal Transplant ◽  
Iga Nephropathy ◽  
Small Vessel Vasculitis ◽  
Iga Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Transplant Patients ◽  
Pubmed Database ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
New Onset

Background: IgA vasculitis is a small-vessel vasculitis caused by deposition of IgA antibodies in tissues. IgA nephropathy and IgAV have long been considered related conditions. Objective: To assess the prevalence and implications of new-onset Henoch-Schönlein purpura (HSP) after renal transplant in patients with underlying IgA nephropathy. Methods: The PubMed database was searched for keywords such as IgAV, IgA vasculitis, Henoch-Schönlein purpura, HSP, IgA nephropathy, and renal transplant. Results: Two cases of new-onset IgA vasculitis post–renal transplant after stopping the prednisone or receiving seasonal influenza vaccine have been reported. We report the case of new-onset IgA cutaneous vasculitis in a renal transplant patient with IgA nephropathy after reduction in his prednisone dosage. Conclusion: The new development of cutaneous IgA vasculitis is unusual in renal transplant patients with IgA nephropathy. Despite these patients’ being immunosuppressed, the presence of IgA vasculitis could signal the recurrence of IgA nephropathy.

Henoch-Schönlein purpura in children: an updated review

2020 ◽  
Vol 16 ◽  
Author(s):  
Alexander K. C. Leung ◽  
Benjamin Barankin ◽  
Kin Fon Leong
Keyword(s):  
English Literature ◽  
Renal Involvement ◽  
Clinical Manifestations ◽  
Current Evidence ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Diffuse Abdominal Pain ◽  
Excellent Outcome ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch-Schönlein purpura (HSP) is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys. It is the most common form of systemic vasculitis in children. Objective: To familiarize physicians with the etiopathogenesis, etiology, clinical manifestations, evaluation, and management of children with Henoch-Schönlein purpura. Methods : A PubMed search was conducted in January 2020 in Clinical Queries using the key terms “Henoch-Schönlein purpura” OR “IgA vasculitis” OR “anaphylactoid purpura”. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews published within the past 10 years. Only papers published in the English literature were included in this review. This paper is based on, but not limited to, the search results. Results: Globally, the incidence of HSP is 10 to 20 cases per 100,000 children per year. Approximately 90% of cases occur in children between 2 and 10 years of age, with a peak incidence at 4 to 7 years. The diagnosis should be based on the finding of palpable purpura in the presence of at least one of the following criteria, namely, diffuse abdominal pain, arthritis or arthralgia, renal involvement (hematuria and/or proteinuria), and a biopsy showing predominant IgA deposition. Most cases are self-limited. The average duration of the disease is 4 weeks. Long-term complications are rare and include persistent hypertension and end-stage kidney disease. Therapy consists of general and supportive measures as well as treatment of the sequelae of the vasculitis. Current evidence does not support universal treatment of HSP patients with corticosteroids. Oral corticosteroids may be considered for HSP patients with severe gastrointestinal pain and gastrointestinal hemorrhage. Conclusions: Most cases of HSP have an excellent outcome, with renal involvement being the the most important prognostic factor in determining morbidity and mortality. Unfortunately, early steroid treatment does not reduce the incidence and severity of nephropathy in children with HSP. In HSP children who have severe nephritis or renal involvement with proteinuria of greater than 3 months, an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker should be considered in addition to corticosteroids to prevent and/or limit secondary glomerular injury.

scholarly journals 119 Location of skin lesions in Henoch-Schonlein purpura (HSP) and its association with renal involvement

2016 ◽  
Vol 136 (5) ◽  
pp. S22
Author(s):  
J. St. John ◽  
A. Garza-Mayers ◽  
P. Vedak ◽  
M. Hoang ◽  
S. Nigwekar ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Location of skin lesions in Henoch-Schönlein purpura and its association with significant renal involvement

2018 ◽  
Vol 78 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Jessica St. John ◽  
Priyanka Vedak ◽  
Anna Cristina Garza-Mayers ◽  
Mai P. Hoang ◽  
Sagar U. Nigwekar ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Steroid Effects on the Course of Abdominal Pain in Children With Henoch-Schonlein Purpura

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1018-1021
Author(s):  
NORMAN D. ROSENBLUM ◽  
HARLAND S. WINTER
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Symptom ◽  
Systemic Vasculitis ◽  
Skin Lesions ◽  
Intestinal Bleeding ◽  
Controlled Trials ◽  
Henoch Schonlein Purpura ◽  
Intestinal Lesions ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura is a systemic vasculitis of unknown cause that is characterized primarily by abdominal pain, arthritis, and purpuric skin lesions. Abdominal pain is the most common gastrointestinal symptom, but intestinal bleeding and intussusception may occur. Previous studies have supported the use of steroids in managing the abdominal pain of Henoch-Schonlein purpura.1,2 Because there are no controlled trials using steroids in this disease, their value in affecting the intestinal lesions of Henoch-Schonlein purpura remains unknown. The purpose of this retrospective study was to assess the effect of corticosteroids on the outcome of abdominal pain in children with Henoch-Schonlein purpura. PATIENTS AND METHODS

Henoch-Schönlein Purpura with Hemorrhagic Bullous Skin Lesions

2011 ◽  
Vol 18 (4) ◽  
pp. 327
Author(s):  
Ji Young Yoon ◽  
Myong Joo Hong ◽  
Wan-Hee Yoo
Keyword(s):  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura
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