scholarly journals Functionalized Derivatives of Benzo-Crown Ethers. Part 4. Antifungal Macrocyclic Supramolecular Complexes of Transition Metal Ions Acting as Lanosterol-14-α -Demethylase Ihibitors

1999 ◽  
Vol 6 (2) ◽  
pp. 101-110 ◽  
Author(s):  
Mihai Barboiu ◽  
Claudiu T. Supuran ◽  
Andrea Scozzafava ◽  
Cornelia Guran ◽  
Paula Diaconescu ◽  
...  
Keyword(s):  
Metal Ions ◽  
Coordination Compounds ◽  
Antifungal Agents ◽  
Transition Metal Ions ◽  
Supramolecular Complexes ◽  
Amino Groups ◽  
Candida Spp ◽  
Physico Chemical ◽  
Antifungal Action ◽  
Derivatives Of

Poly- and mononuclear metal complexes of 2,3,11,12-bis[4-(10-aminodecylcarbonyl)]benzo-18- crown-6 (L) and Cu(II); Ni(II); Co(II) and Cr(III) have been synthesized and characterized by standard physico-chemical procedures. In the newly prepared complexes the crown moiety oxygen atoms of the macrocyclic host did not generally interact with metal ions, whereas the two amino groups of the ligand always did. Several of the newly synthesized compounds act as effective antifungal agents against Aspergillus and Candida spp., some of them showing activities comparable to ketoconazole, with minimum inhibitory concentrations in the range of 0.3−0.5 μg/mL . The mechanism of antifungal action of these coordination compounds is probably connected to an inhibition of lanosterol-14-α -demethylase, a metallo-enzyme playing a key role in sterol biosynthesis in fungi, bacteria and eukariotes.

Fluorescence Enhancement of Polyamine Derivatives of 1,8-Naphthalimide with Transition Metal Ions

2006 ◽  
Vol 19 (6) ◽  
pp. 506-510 ◽  
Author(s):  
Guo-tao Wen ◽  
Man-zhou Zhu ◽  
Zhuo Wang ◽  
Xiang-ming Meng ◽  
Hui-yuan Hu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Fluorescence Enhancement ◽  
Transition Metal Ions ◽  
Derivatives Of ◽  
Polyamine Derivatives

scholarly journals Supramolecular complexes of cobalt(II), manganese(II) and cadmium(II) with bis(terpyridine) ligand as novel luminescent materials

2013 ◽  
Vol 15 (3) ◽  
pp. 91-95 ◽  
Author(s):  
Monika Wałęsa-Chorab ◽  
Adam Gorczyński ◽  
Damian Marcinkowski ◽  
Zbigniew Hnatejko ◽  
Violetta Patroniak
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Electronic Absorption ◽  
Self Assembly ◽  
Emission Spectra ◽  
Transition Metal Ions ◽  
Supramolecular Complexes ◽  
Luminescent Materials ◽  
Absorption And Emission ◽  
Counter Ions

Abstract Self-assembly of N6-donor bis(terpyridine) ligand L with transition metal ions: Co(II), Mn(II) and Cd(II) leads to a formation of three kinds of supramolecular complexes. In the electronic absorption and emission spectra of supramolecular complexes additional bands were observed what was ascribed to the coordination of ligand molecules to metal ions. Luminescence properties of these complexes strongly depend on the kind of metal ions and counter ions. The effective blue luminescence was observed in the case of Mn(II) and Cd(II) complexes in which all N-donor atoms of ligand molecules coordinate with the metal center

2-Thioxo-tetrahydro-4H-imidazol-4-ones, 2-alkylthio-3,5-dihydro-4H-imidazol-4-ones and their coordination compounds with transition metal ions

2011 ◽  
Vol 1 (4) ◽  
pp. 309-343 ◽  
Author(s):  
E. K. Beloglazkina ◽  
A. G. Majouga ◽  
E. A. Manzhelii ◽  
N. V. Zyk ◽  
N. S. Zefirov
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Transition Metal Ions

scholarly journals Complexes With Biologically Active Ligands. Part 4. Coordination Compounds of Chlorothiazide With Transition Metal Ions Behave as Strong Carbonic Anhydrase Inhibitors

1996 ◽  
Vol 3 (2) ◽  
pp. 79-83 ◽  
Author(s):  
Claudiu T. Supuran
Keyword(s):  
Transition Metal ◽  
Carbonic Anhydrase ◽  
Metal Ions ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Transition Metal Ions ◽  
Biologically Active ◽  
Carbonic Anhydrase Inhibitors

Complexes of the diuretic benzothiadiazine derivative chlorothiazide (6-chloro-7-sulfamoyl- 1,2,4-benzothiadiazine-1,1-dioxide) with V(IV); Fe(II); Co(II); Ni(II); Cu(II), Ag(I) and U(VI) were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes behave as effective inhibitors for two isozymes (I and II) of carbonic anhydrase (CA).

Coordination compounds in a pentacyclic aromatic system from 2-aminobenzothiazole derivatives and transition metal ions

Polyhedron ◽  
2006 ◽  
Vol 25 (12) ◽  
pp. 2363-2374 ◽  
Author(s):  
Fabiola Téllez ◽  
Adrian Peña-Hueso ◽  
Noráh Barba-Behrens ◽  
Rosalinda Contreras ◽  
Angelina Flores-Parra
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Transition Metal Ions ◽  
Aromatic System

Physico-chemical study of the complex formation between 2-(tosylamino)benzaldehyde bishydrazones and transition metal ions

2015 ◽  
Vol 85 (8) ◽  
pp. 1902-1909 ◽  
Author(s):  
L. D. Popov ◽  
Yu. P. Tupolova ◽  
S. I. Levchenkov ◽  
A. A. Tsaturyan ◽  
V. V. Lukov ◽  
...  
Keyword(s):  
Complex Formation ◽  
Transition Metal ◽  
Metal Ions ◽  
Chemical Study ◽  
Transition Metal Ions ◽  
Physico Chemical
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