De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

2009 ◽  
Vol 69 (23) ◽  
pp. 8949-8957 ◽  
Author(s):  
James W. Watters ◽  
Chun Cheng ◽  
Pradip K. Majumder ◽  
Ruojie Wang ◽  
Sireesha Yalavarthi ◽  
...  
RSC Advances ◽  
2020 ◽  
Vol 10 (48) ◽  
pp. 28483-28483
Author(s):  
N. Sanoj Rejinold ◽  
Reju George Thomas ◽  
Muthunarayanan Muthiah ◽  
K. P. Chennazhi ◽  
In-Kyu Park ◽  
...  

Retraction of ‘Radio frequency triggered curcumin delivery from thermo and pH responsive nanoparticles containing gold nanoparticles and its in vivo localization studies in an orthotopic breast tumor model’ by N. Sanoj Rejinold et al., RSC Adv., 2014, 4, 39408–39427, DOI: 10.1039/C4RA05727A.


2021 ◽  
Vol 12 ◽  
Author(s):  
Jiafeng Gao ◽  
Yi-Nan Zhang ◽  
Jingwen Cui ◽  
Jiatong Zhang ◽  
Yuexiang Ming ◽  
...  

Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) that mediate T-cell immune responses. Breast cancer is one of the most commonly diagnosed diseases and its mortality rate is higher than any other cancer in both humans and canines. Plantain polysaccharide (PLP), extracted from the whole plant of Plantago asiatica L., could promote the maturation of DCs. In this research, we found that PLP could upregulate the maturation of DCs both in vitro and in vivo. PLP-activated DCs could stimulate lymphocytes’ proliferation and differentiate naive T cells into cytotoxic T cells. Tumor antigen-specific lymphocyte responses were enhanced by PLP and CIPp canine breast tumor cells lysate-pulsed DCs, and PLP and CIPp-cell-lysate jointly stimulated DCs cocultured with lymphocytes having the great cytotoxicity on CIPp cells. In the 4T1 murine breast tumor model, PLP could control the size of breast tumors and improve immunity by recruiting DCs, macrophages, and CD4+ and CD8+ T cells in the tumor microenvironment. These results indicated that PLP could achieve immunotherapeutic effects and improve immunity in the breast tumor model.


2010 ◽  
Author(s):  
Min Wu ◽  
Kimberly Clark ◽  
Nanhua Deng ◽  
Zuhua Cai ◽  
Megan E. Serpa ◽  
...  

Author(s):  
Xosé Luís Deán-Ben ◽  
Vladimir Ermolayev ◽  
Subhamoy Mandal ◽  
Vasilis Ntziachristos ◽  
Daniel Razansky

2007 ◽  
Vol 57 (7) ◽  
pp. 1067-1077 ◽  
Author(s):  
Claudia Gravekamp ◽  
Belinda Leal ◽  
Ashley Denny ◽  
Rumana Bahar ◽  
Shellye Lampkin ◽  
...  

2016 ◽  
Vol 88 (6) ◽  
pp. 3107-3114 ◽  
Author(s):  
Nadine E. Mascini ◽  
Menglin Cheng ◽  
Lu Jiang ◽  
Asif Rizwan ◽  
Helen Podmore ◽  
...  

2018 ◽  
Vol 140 ◽  
pp. 278-288 ◽  
Author(s):  
Brígida Gomes de Almeida Schirmer ◽  
Marina Rios de Araujo ◽  
Marina Bicalho Silveira ◽  
Jousie Michel Pereira ◽  
Lorena Carla Vieira ◽  
...  

2005 ◽  
Vol 18 (3) ◽  
pp. 138-143 ◽  
Author(s):  
C. Corot ◽  
P. Robert ◽  
E. Lancelot ◽  
A. Martinell ◽  
R. Santus

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