Abstract P6-10-02: MLN8237 (alisertib), an investigational Aurora A Kinase inhibitor, in patients with breast cancer: Emerging phase 2 results

2012 ◽  
Author(s):  
RH Alvarez ◽  
A DeMichele ◽  
A Mailliez ◽  
E Benaim ◽  
H Fingert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Kinase Inhibitor ◽  
Aurora A Kinase ◽  
Phase 2 ◽  
Aurora A

Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose

2015 ◽  
Vol 33 (4) ◽  
pp. 942-953 ◽  
Author(s):  
Karthik Venkatakrishnan ◽  
Tae Min Kim ◽  
Chia-Chi Lin ◽  
Lim Soon Thye ◽  
Wee Joo Chng ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Kinase Inhibitor ◽  
Phase 1 ◽  
East Asian ◽  
Aurora A Kinase ◽  
Phase 2 ◽  
Aurora A ◽  
Phase 1 Study

Nuclear Aurora-A kinase-induced hypoxia signaling drives early dissemination and metastasis in breast cancer: implications for detection of metastatic tumors

Oncogene ◽  
2021 ◽  
Author(s):  
Kristina M. Whately ◽  
Maria A. Voronkova ◽  
Abha Maskey ◽  
Jasleen Gandhi ◽  
Juergen Loskutov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Metastatic Tumors ◽  
Hypoxia Signaling

scholarly journals Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies

2017 ◽  
Vol 36 (2) ◽  
pp. 240-247 ◽  
Author(s):  
Xiaofei Zhou ◽  
John Nemunaitis ◽  
Shubham Pant ◽  
Todd M. Bauer ◽  
Manish Patel ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Qtc Interval ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Advanced Malignancies

scholarly journals The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent

Cell Cycle ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 807-817 ◽  
Author(s):  
Jayasree S. Nair ◽  
Alan L. Ho ◽  
Gary K. Schwartz
Keyword(s):  
Kinase Inhibitor ◽  
Aurora A Kinase ◽  
Aurora A
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