scholarly journals Signal Pathway of Hypoxia-Inducible Factor-1α Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells

2005 ◽  
Vol 11 (21) ◽  
pp. 7607-7613 ◽  
Author(s):  
Seok J. Kwon ◽  
Jae J. Song ◽  
Yong J. Lee
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Signal Pathway ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau ◽  
Hypoxia Inducible Factor 1Α ◽  
Pancreatic Cancer Cells

scholarly journals von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms

2006 ◽  
Vol 66 (3) ◽  
pp. 1553-1560 ◽  
Author(s):  
Maria J. Calzada ◽  
Miguel A. Esteban ◽  
Monica Feijoo-Cuaresma ◽  
Maria C. Castellanos ◽  
Salvador Naranjo-Suárez ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Hypoxia Inducible Factor ◽  
Intercellular Junctions ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau

Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel–Lindau tumor suppressor protein

2018 ◽  
Vol 20 (27) ◽  
pp. 18756-18765
Author(s):  
Hongsheng Qian ◽  
Yu Zou ◽  
Yiming Tang ◽  
Yehong Gong ◽  
Zhenyu Qian ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Conformational Change ◽  
Hypoxia Inducible Factor ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau ◽  
Hypoxia Inducible Factor 1Α ◽  
Proline Hydroxylation

Proline hydroxylation of HIF-1α affects the interaction affinity between pVHL and HIF-1α and allosterically induces the conformational change of pVHL.

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