Triptolide suppresses proliferation, hypoxia-inducible factor-1α and c-Myc expression in pancreatic cancer cells

Molecular Medicine Reports ◽

10.3892/mmr.2015.3960 ◽

2015 ◽

Vol 12 (3) ◽

pp. 4508-4513 ◽

Author(s):

XIAOLING DING ◽

XIAORONG ZHOU ◽

BO JIANG ◽

QUN ZHAO ◽

GUOXIONG ZHOU

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells

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Signal Pathway of Hypoxia-Inducible Factor-1α Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-05-0981 ◽

2005 ◽

Vol 11 (21) ◽

pp. 7607-7613 ◽

Author(s):

Seok J. Kwon ◽

Jae J. Song ◽

Yong J. Lee

Keyword(s):

Pancreatic Cancer ◽

Tumor Suppressor ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Signal Pathway ◽

Tumor Suppressor Protein ◽

Von Hippel Lindau ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells

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Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism

American Journal Of Pathology ◽

10.1016/s0002-9440(10)63924-7 ◽

2003 ◽

Vol 162 (4) ◽

pp. 1283-1291 ◽

Author(s):

Jian Chen ◽

Songji Zhao ◽

Kunihiro Nakada ◽

Yuji Kuge ◽

Nagara Tamaki ◽

...

Keyword(s):

Pancreatic Cancer ◽

Glucose Metabolism ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Dominant Negative ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells

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Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells

10.18632/oncotarget.21330 ◽

2017 ◽

Vol 8 (50) ◽

pp. 88008-88020 ◽

Author(s):

Lijuan Hu ◽

Rui Cui ◽

Hongyi Liu ◽

Feng Wang

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Cancer Cachexia ◽

Hypoxia Inducible Factor ◽

Human Pancreatic Cancer ◽

Athymic Mice ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells

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Pancreatic Cancer Cells Expressing Hypoxia-Inducible Factor-1α Tend to Be Adjacent to Intratumoral Blood Vessels

European Surgical Research ◽

10.1159/000319876 ◽

2010 ◽

Vol 45 (3-4) ◽

pp. 134-137 ◽

Author(s):

B.-Q. Cheng ◽

R. Segersvärd ◽

J. Permert ◽

F. Wang

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Blood Vessels ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells

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Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration

Cancer Biology & Therapy ◽

10.4161/cbt.23786 ◽

2013 ◽

Vol 14 (5) ◽

pp. 428-435 ◽

Author(s):

Zhiwen Liu ◽

Xiaohui Jia ◽

Yijie Duan ◽

Huijie Xiao ◽

Karl-Gösta Sundqvist ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cell Migration ◽

Glucose Metabolism ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells ◽

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Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells

Pathobiology ◽

10.1159/000325538 ◽

2011 ◽

Vol 78 (4) ◽

pp. 181-192 ◽

Author(s):

Okito Hashimoto ◽

Kazuya Shimizu ◽

Shuho Semba ◽

Sachie Chiba ◽

Yonson Ku ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Dependent Manner ◽

Tumor Aggressiveness ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells

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Insulin promotes proliferative vitality and invasive capability of pancreatic cancer cells via hypoxia-inducible factor 1α pathway

Journal of Huazhong University of Science and Technology [Medical Sciences] ◽

10.1007/s11596-010-0355-2 ◽

2010 ◽

Vol 30 (3) ◽

pp. 349-353 ◽

Author(s):

Li Wang ◽

Wei Zhou ◽

Shanmiao Gou ◽

Tongling Wang ◽

Tao Liu ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1Α ◽

Pancreatic Cancer Cells ◽

Invasive Capability

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Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells

Cancer Letters ◽

10.1016/j.canlet.2014.08.001 ◽

2014 ◽

Vol 354 (1) ◽

pp. 172-180 ◽

Author(s):

He Ren ◽

Lingling Jia ◽

Tiansuo Zhao ◽

Huan Zhang ◽

Jing Chen ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Leptin Receptor ◽

Hypoxia Inducible Factor ◽

Pancreatic Cancer Cells

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Abstract A35: Insulin and hypoxia-inducible factor-1 cooperate to increase the viability of pancreatic cancer cells

10.1158/1538-7445.panca2014-a35 ◽

2015 ◽

Author(s):

Yue Chen ◽

Dapeng Zhang ◽

Lihua Cui ◽

Feng Wang

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Pancreatic Cancer Cells

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Hypoxia Inducible Factor-1 Mediates Effects of Insulin on Pancreatic Cancer Cells and Disturbs Host Energy Homeostasis

American Journal Of Pathology ◽

10.2353/ajpath.2007.060489 ◽

2007 ◽

Vol 170 (2) ◽

pp. 469-477 ◽

Author(s):

Feng Wang ◽

Shu Shun Li ◽

Ralf Segersvärd ◽

Lisa Strömmer ◽

Karl-Gösta Sundqvist ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Energy Homeostasis ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Pancreatic Cancer Cells

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