A histone deacetylase inhibitor, panobinostat, enhances chimeric receptor antigen T cell anti-tumor effect against pancreatic cancer

Chimeric Receptor ◽

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

International Journal of Cancer ◽

10.1002/ijc.22558 ◽

2007 ◽

Vol 121 (3) ◽

pp. 656-665 ◽

Cited By ~ 123

Author(s):

Takashi Kumagai ◽

Naoki Wakimoto ◽

Dong Yin ◽

Sigal Gery ◽

Norihiko Kawamata ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Hydroxamic Acid ◽

Human Pancreatic Cancer ◽

Suberoylanilide Hydroxamic Acid ◽

Pancreatic Cancer Cells ◽

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T cell lymphoma

European Journal Of Haematology ◽

10.1111/j.1600-0609.2009.01239.x ◽

2009 ◽

Vol 82 (6) ◽

pp. 440-449 ◽

Cited By ~ 67

Author(s):

Ulrike Heider ◽

Jessica Rademacher ◽

Britta Lamottke ◽

Maren Mieth ◽

Markus Moebs ◽

...

Keyword(s):

T Cell ◽

Histone Deacetylase ◽

Proteasome Inhibitor ◽

Cell Lymphoma ◽

Synergistic Interaction ◽

T Cell Lymphoma ◽

Cutaneous T Cell Lymphoma ◽

p21Cip1 up-regulated during histone deacetylase inhibitor-induced CD4+ T-cell anergy selectively associates with mitogen-activated protein kinases

Immunology ◽

10.1111/j.1365-2567.2009.03161.x ◽

2009 ◽

Vol 129 (4) ◽

pp. 589-599 ◽

Cited By ~ 4

Author(s):

Ayse Selma Dagtas ◽

Kathleen M. Gilbert

Keyword(s):

T Cell ◽

Protein Kinases ◽

Histone Deacetylase ◽

Cd4 T Cell ◽

Mitogen Activated Protein Kinases ◽

T Cell Anergy ◽

Deacetylase Inhibitor ◽

Mitogen Activated Protein ◽

Cell Anergy

Abstract 203: The histone deacetylase inhibitor LBH589 sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through induction of c-FLIP degradation

10.1158/1538-7445.am10-203 ◽

2010 ◽

Author(s):

John Kauh ◽

Songqing Fan ◽

Lily Yang ◽

Fadlo R. Khuri ◽

Shi-Yong Sun

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor ◽

Induced Apoptosis

Abstract 4078: Antitumor effect of the histone deacetylase inhibitor MS-275 in combination with retinoic acid Am80 in human cutaneous T-cell lymphoma

10.1158/1538-7445.am2012-4078 ◽

2012 ◽

Author(s):

Yukihiko Kato ◽

Chizu Egusa ◽

Tatsuo Maeda ◽

Ryoji Tsuboi

Keyword(s):

Retinoic Acid ◽

T Cell ◽

Histone Deacetylase ◽

Antitumor Effect ◽

Cell Lymphoma ◽

T Cell Lymphoma ◽

Cutaneous T Cell Lymphoma ◽

Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.16.7.1111 ◽

2007 ◽

Vol 16 (7) ◽

pp. 1111-1120 ◽

Cited By ~ 210

Author(s):

Madeleine Duvic ◽

Jenny Vu

Keyword(s):

T Cell ◽

Histone Deacetylase ◽

Cell Lymphoma ◽

T Cell Lymphoma ◽

Cutaneous T Cell Lymphoma ◽

Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas

Nature Clinical Practice Oncology ◽

10.1038/ncponc1238 ◽

2008 ◽

Vol 5 (12) ◽

pp. 714-726 ◽

Cited By ~ 61

Author(s):

Omar Khan ◽

Nicholas B La Thangue

Keyword(s):

T Cell ◽

Histone Deacetylase ◽

T Cell Lymphomas ◽

The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

BMC Cancer ◽

10.1186/1471-2407-3-30 ◽

2003 ◽

Vol 3 (1) ◽

Cited By ~ 105

Author(s):

José Manuel Afonso Moreira ◽

Peter Scheipers ◽

Poul Sørensen

Keyword(s):

T Cell ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor Trichostatin

Trichostatin A ◽

T Cell Responses ◽

Cd4 T Cell ◽

Cell Responses ◽

Deacetylase Inhibitor ◽

FR901228, a novel histone deacetylase inhibitor, induces cell cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells

International Journal of Oncology ◽

10.3892/ijo.24.3.679 ◽

2004 ◽

Cited By ~ 6

Author(s):

Nariatsu Sato ◽

Tetsuo Ohta ◽

Hirohisa Kitagawa ◽

Masato Kayahara ◽

Itasu Ninomiya ◽

...

Keyword(s):

Cell Cycle ◽

Pancreatic Cancer ◽

Cell Cycle Arrest ◽

Cancer Cells ◽

Histone Deacetylase ◽

Human Pancreatic Cancer ◽

Cycle Arrest ◽

Pancreatic Cancer Cells ◽

Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo

Molecular Carcinogenesis ◽

10.1002/mc.22024 ◽

2013 ◽

Vol 53 (9) ◽

pp. 722-735 ◽

Cited By ~ 37

Author(s):

Wenwen Chien ◽

Dhong Hyun Lee ◽

Yun Zheng ◽

Peer Wuensche ◽

Rosie Alvarez ◽

...

Keyword(s):

Pancreatic Cancer ◽

Growth Inhibition ◽

Cancer Cells ◽

Histone Deacetylase ◽

Mtor Signaling ◽

Pancreatic Cancer Cells ◽