scholarly journals Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

2006 ◽  
Vol 5 (1) ◽  
pp. 160-169 ◽  
Author(s):  
Holly K. Koblish ◽  
Shuyuan Zhao ◽  
Carol F. Franks ◽  
Robert R. Donatelli ◽  
Rose M. Tominovich ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Human Tumor ◽  
Tumor Cell Proliferation ◽  
Human Tumor Cell ◽  
Proliferation In Vitro

In Vitro Effects of Glycosphingolipids on Human Tumor Cell Proliferation

1981 ◽  
Vol 166 (1) ◽  
pp. 107-112 ◽  
Author(s):  
P. M. Kimball ◽  
L. Hammonds ◽  
J. M. McKibbin ◽  
M. G. Brattain ◽  
G. Glover ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Human Tumor ◽  
Tumor Cell Proliferation ◽  
Human Tumor Cell ◽  
In Vitro Effects

ErbB3 Inhibitory Surrobodies Inhibit Tumor Cell Proliferation In Vitro and In Vivo

2012 ◽  
Vol 11 (7) ◽  
pp. 1411-1420 ◽  
Author(s):  
Pamela K. Foreman ◽  
Medini Gore ◽  
Philip A. Kobel ◽  
Li Xu ◽  
Helena Yee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Tumor Cell Proliferation ◽  
Proliferation In Vitro ◽  
Inhibit Tumor Cell Proliferation

scholarly journals The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome

2020 ◽  
Author(s):  
Iolanda Ferro ◽  
Jacopo Gavini ◽  
Lisamaria Bracher ◽  
Marc Landolfo ◽  
Daniel Candinas ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Chemotherapy Resistance ◽  
Autophagic Flux ◽  
Tumor Cell Proliferation ◽  
Apoptosis Resistance ◽  
Knock Out ◽  
Vault Rna

AbstractThe small non-coding vault RNA (vtRNA) 1-1 has been shown to confer apoptosis resistance in several malignant cell lines and also to modulate the autophagic flux in hepatocytes, thus highlighting its pro-survival role. Here we describe a new function of vtRNA1-1 in regulating in vitro and in vivo tumor cell proliferation, tumorigenesis and chemoresistance. By activating extracellular signal-regulated kinases (ERK 1/2), vtRNA1-1 knock-out (KO) inhibits transcription factor EB (TFEB), leading to a downregulation of the coordinated lysosomal expression and regulation (CLEAR) network genes and lysosomal compartment dysfunction. Pro-tumorigenic pathways dysregulation and decreased lysosome functionality potentiate the anticancer effect of conventional targeted cancer drugs in the absence of vtRNA1-1. Finally, vtRNA1-1 KO-reduced lysosomotropism, together with a higher intracellular compound availability, significantly reduced tumor cell proliferation in vitro and in vivo. These findings reveal the role of vtRNA1-1 in ensuring intracellular catabolic compartment stability and functionality, suggesting its importance in lysosome-mediated chemotherapy resistance.

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