Abstract CC04-01: First-in-human biomarker-driven phase I TRESR trial of ataxia telangiectasia and Rad3-related inhibitor (ATRi) RP-3500 in patients (pts) with advanced solid tumors harboring synthetic lethal (SL) genomic alterations

2021 ◽  
Author(s):  
Timothy Yap ◽  
Elizabeth Lee ◽  
David Spigel ◽  
Elisa Fontana ◽  
Martin Højgaard ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Ataxia Telangiectasia ◽  
Advanced Solid Tumors ◽  
Genomic Alterations ◽  
Synthetic Lethal

scholarly journals A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma

2014 ◽  
Vol 20 (14) ◽  
pp. 3683-3691 ◽  
Author(s):  
Donald W. Northfelt ◽  
Ramesh K. Ramanathan ◽  
Peter A. Cohen ◽  
Daniel D. Von Hoff ◽  
Glen J. Weiss ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Finding ◽  
Advanced Solid Tumors ◽  
The Novel ◽  
Toll Like Receptor ◽  
Finding Study ◽  
Dose Finding Study

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

2014 ◽  
Vol 32 (4) ◽  
pp. 653-660 ◽  
Author(s):  
Colin D. Weekes ◽  
Muralidhar Beeram ◽  
Anthony W. Tolcher ◽  
Kyriakos P. Papadopoulos ◽  
Lia Gore ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Study ◽  
Advanced Solid Tumors

A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of α2 integrin inhibitor E7820 in patients with advanced solid tumors

2016 ◽  
Vol 34 (3) ◽  
pp. 329-337 ◽  
Author(s):  
B. Milojkovic Kerklaan ◽  
S. Slater ◽  
M. Flynn ◽  
A. Greystoke ◽  
P. O. Witteveen ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Food Effect ◽  
Effect Study ◽  
Advanced Solid Tumors ◽  
Integrin Inhibitor

scholarly journals A phase I study of Triapine® in combination with doxorubicin in patients with advanced solid tumors

2008 ◽  
Vol 63 (6) ◽  
pp. 1147-1156 ◽  
Author(s):  
William R. Schelman ◽  
Sherry Morgan-Meadows ◽  
Rebecca Marnocha ◽  
Fred Lee ◽  
Jens Eickhoff ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Study ◽  
Advanced Solid Tumors

A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors

2009 ◽  
Vol 66 (3) ◽  
pp. 441-448 ◽  
Author(s):  
E. Gabriela Chiorean ◽  
Srikar Malireddy ◽  
Anne E. Younger ◽  
David R. Jones ◽  
Mary-Jane Waddell ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Pharmacokinetic Study ◽  
Dose Escalation ◽  
Advanced Solid Tumors

REO-001: A phase I trial of percutaneous intralesional administration of reovirus type 3 dearing (Reolysin®) in patients with advanced solid tumors

2012 ◽  
Vol 31 (3) ◽  
pp. 696-706 ◽  
Author(s):  
Don G. Morris ◽  
Xiaolan Feng ◽  
Lisa M. DiFrancesco ◽  
Kevin Fonseca ◽  
Peter A Forsyth ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Trial ◽  
Advanced Solid Tumors ◽  
Reovirus Type ◽  
Intralesional Administration ◽  
Type 3
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