Faculty Opinions recommendation of Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma.

Author(s):  
Qing Zhong
2012 ◽  
Vol 31 (3) ◽  
pp. 696-706 ◽  
Author(s):  
Don G. Morris ◽  
Xiaolan Feng ◽  
Lisa M. DiFrancesco ◽  
Kevin Fonseca ◽  
Peter A Forsyth ◽  
...  

2021 ◽  
Author(s):  
Geraldine O'Sullivan Coyne ◽  
Khanh T. Do ◽  
Shivaani Kummar ◽  
Naoko Takebe ◽  
Sarina Piha-Paul ◽  
...  

Author(s):  
Philippe L. Bedard ◽  
David W. Cescon ◽  
Graham Fletcher ◽  
Trish Denny ◽  
Richard Brokx ◽  
...  

2020 ◽  
Author(s):  
Shelby Barnett ◽  
Melanie Griffin ◽  
Richard H. Wilson ◽  
Elizabeth R. Plummer ◽  
Jeffry T. Evans ◽  
...  

Author(s):  
Jean-Pierre Delord ◽  
Antoine Italiano ◽  
Ahmad Awada ◽  
Philippe Aftimos ◽  
Nadine Houédé ◽  
...  

2019 ◽  
Vol 84 (4) ◽  
pp. 899-907 ◽  
Author(s):  
Janice M. Mehnert ◽  
Amanda D. Kaveney ◽  
Jyoti Malhotra ◽  
Kristen Spencer ◽  
Daniella Portal ◽  
...  

2020 ◽  
Vol 8 (2) ◽  
pp. e000870
Author(s):  
Aung Naing ◽  
Joseph P Eder ◽  
Sarina A Piha-Paul ◽  
Claude Gimmi ◽  
Elizabeth Hussey ◽  
...  

BackgroundM4112 is an oral, potent, and selective indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) dual inhibitor. Here, we report preclinical data and first-in-human phase I data, including safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy, of M4112 monotherapy in patients with advanced solid tumors.MethodsIn preclinical studies, M4112 was administered to mice with IDO1-expressing tumors to determine tumor IDO1 and liver TDO2 inhibition. In the phase I trial, patients received doses of M4112 two times per day in 28-day cycles until progression, toxicity, or withdrawal of consent. The primary objective was to determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D). The primary endpoint was the incidence of dose-limiting toxicities (DLTs), treatment-emergent adverse events (TEAEs), and treatment-emergent changes in safety parameters. Other endpoints included pharmacokinetics, pharmacodynamics, and antitumor effects.ResultsIn mice, M4112 significantly decreased the kynurenine:tryptophan ratio in the liver and tumor. Fifteen patients received M4112 at five distinct dose levels (three patients per cohort: 100, 200, 400, 600, and 800 mg two times per day orally). Initially, all doses inhibited IDO1 ex vivo, but plasma kynurenine levels returned to or exceeded baseline levels after day 15. Despite initial changes in kynurenine, there was no significant reduction of plasma kynurenine at steady state. There was one DLT (grade 3 allergic dermatitis; 800 mg two times per day) and one grade 2 QT prolongation (800 mg two times per day), resulting in dose reduction (not a DLT). M4112 was well tolerated, and neither the MTD nor the RP2D was established. TEAEs included fatigue, nausea, and vomiting. The best overall response was stable disease (n=9, 60%).ConclusionsThere were no serious safety concerns at any dose. Although M4112 inhibited IDO1 activity ex vivo, plasma kynurenine levels were not reduced despite achieving target exposure.Trial registration numberNCT03306420.


2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 2132-2132
Author(s):  
A. Chiappori ◽  
G. R. Simon ◽  
L. Kvols ◽  
L. Tetteh ◽  
J. J. Mahany ◽  
...  

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