Abstract 4781: Analysis of a new chemopreventative agent SHetA2 and its metabolites in Beagle dog liver and plasma

2012 ◽  
Author(s):  
Alexander D. Zakharov ◽  
Kasim K. Kabirov ◽  
Dejan Nikolić ◽  
Lian Chen ◽  
Irina Mankovskaya ◽  
...  
Keyword(s):  
Beagle Dog ◽  
Dog Liver

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

2014 ◽  
Vol 32 (1) ◽  
pp. 74-90 ◽  
Author(s):  
Aki T. Heikkinen ◽  
Arno Friedlein ◽  
Mariette Matondo ◽  
Oliver J. D. Hatley ◽  
Aleksanteri Petsalo ◽  
...  
Keyword(s):  
Beagle Dog ◽  
Dog Liver

Endothelin Antagonist-Induced Coronary and Systemic Arteritis in the Beagle Dog

2003 ◽  
Vol 31 (3) ◽  
pp. 263-272
Author(s):  
Allen Macpherson ◽  
Graham R. Betton ◽  
A. Stewart Davis ◽  
Robert Siddall ◽  
Peter Greaves ◽  
...  
Keyword(s):  
Beagle Dog ◽  
Endothelin Antagonist

Acyl-Enzymes as Thrombolytic Agents in Dog Models of Venous Thrombosis and Pulmonary Embolism

1984 ◽  
Vol 51 (02) ◽  
pp. 248-253 ◽  
Author(s):  
R J Dupe ◽  
P D English ◽  
R A G Smith ◽  
J Green
Keyword(s):  
Pulmonary Embolism ◽  
Side Effects ◽  
Venous Thrombosis ◽  
Active Site ◽  
Acute Pulmonary Embolism ◽  
Quantitative Model ◽  
Beagle Dog ◽  
Thrombosis Model ◽  
Derivatives Of

SummaryA quantitative model of venous thrombosis in the beagle dog is described. The model was adapted to permit ageing of isolated experimental clots in vivo. A model of acute pulmonary embolism in this species is also described. In the venous thrombosis model, infusion of streptokinase (SK) or SK-activated human plasmin gave significant lysis but bolus doses of SK. plasmin complex were ineffective. Active site anisoylated derivatives of SK. plasminogen complex, SK-activated plasmin and activator-free plasmin were all active when given as bolus doses in both models. At lytic doses, the acyl-enzymes caused fewer side-effects attributable to plasminaemia than the corresponding unmodified enzymes.

METABOLISM OF PREGNENOLONE-3-SULPHATE IN THE PERFUSED DOG LIVER

1965 ◽  
Vol 49 (3) ◽  
pp. 427-435 ◽  
Author(s):  
K. D. Voigt ◽  
J. Tamm ◽  
U. Volkwein ◽  
H. Schedewie
Keyword(s):  
Metabolic Pathways ◽  
Dog Liver ◽  
Steroid Conjugates

ABSTRACT Pregnenolone-sulphate (400 mg) was perfused through isolated dog livers. The following steroids were isolated in the perfusate: pregnenolone, progesterone, dehydroepiandrosterone, androst-5-ene-diol and the two steroid conjugates, i. e. pregnenolone-sulphate and dehydroepiandrosterone-sulphate. Two »free« steroids and one steroid conjugate could not be characterized. A tentative scheme for the metabolic pathways of pregnenolone-sulphate is presented.

scholarly journals Non-viral derivation of a transgene-free induced pluripotent stem cell line from a male beagle dog

2021 ◽  
Vol 53 ◽  
pp. 102375
Author(s):  
Sho Yoshimatsu ◽  
Kazuya Edamura ◽  
Yumi Yoshii ◽  
Aozora Iguchi ◽  
Hirotaka Kondo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Line ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stem Cell Line ◽  
Beagle Dog ◽  
Induced Pluripotent

scholarly journals Cystic Calculosis Repeating in a Beagle Dog

1979 ◽  
Vol 41 (4) ◽  
pp. 413-415
Author(s):  
Satoshi FUKUDA ◽  
Osamu MATSUOKA
Keyword(s):  
Beagle Dog
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