Abstract 3320: Combined effect of zoledronic acid and telomerase-specific oncolytic virotherapy for human osteosarcoma cells.

2013 ◽  
Author(s):  
Yasuaki Yamakawa ◽  
Joe Hasei ◽  
Hiroshi Tazawa ◽  
Shuhei Osaki ◽  
Tsuyoshi Sasaki ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Combined Effect ◽  
Oncolytic Virotherapy ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

Anticancer effects of zoledronic acid against human osteosarcoma cells

2006 ◽  
Vol 24 (6) ◽  
pp. 1145-1152 ◽  
Author(s):  
B. Kubista ◽  
K. Trieb ◽  
F. Sevelda ◽  
C. Toma ◽  
F. Arrich ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Human Osteosarcoma Cells

Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells

2014 ◽  
Vol 22 (1) ◽  
pp. 66-72 ◽  
Author(s):  
Antonietta Rizzo ◽  
Gabriella Misso ◽  
Nazario Bevilacqua ◽  
Giovanna Donnarumma ◽  
Angela Lombardi ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Chlamydia Pneumoniae ◽  
Cytokine Production ◽  
Osteosarcoma Cells ◽  
Cytotoxic Effects ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

Antiproliferative properties of oleuropein in human osteosarcoma cells

2016 ◽  
Author(s):  
Jose M Moran ◽  
Olga Leal-Hernandez ◽  
Maria L Canal-Macias ◽  
Jesus M Lavado-Garcia ◽  
Raul Roncero-Martin ◽  
...  
Keyword(s):  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

Copper(II) Complexes with Saccharinate and Glutamine as Antitumor Agents: Cytoand Genotoxicity in Human Osteosarcoma Cells

2017 ◽  
Vol 17 (3) ◽  
pp. 424-433 ◽  
Author(s):  
Juan Cadavid-Vargas ◽  
Ignacio Leon ◽  
Susana Etcheverry ◽  
Eduardo Santi ◽  
Maria Torre ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

scholarly journals Assessment of the Nutraceutical Effects of Oleuropein and the Cytotoxic Effects of Adriamycin, When Administered Alone and in Combination, in MG-63 Human Osteosarcoma Cells

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 354
Author(s):  
Katerina Gioti ◽  
Anastasia Papachristodoulou ◽  
Dimitra Benaki ◽  
Nektarios Aligiannis ◽  
Alexios-Leandros Skaltsounis ◽  
...  
Keyword(s):  
Chemotherapeutic Agent ◽  
Molecular Techniques ◽  
Osteosarcoma Cells ◽  
Elisa Method ◽  
Chain Reaction ◽  
Cytotoxic Effects ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Anti Cancer ◽  
Polymerase Chain

Oleuropein (OLEU) is the most distinguished phenolic compound found in olive fruit and the leaves of Olea europaea L., with several pharmacological properties, including anti-cancer actions. Adriamycin (ADR) is an anthracycline widely used as a chemotherapeutic agent, although it presents significant side effects. The aim of the present study was to investigate the effect of oleuropein alone (20 μg/mL) and in co-treatment with ADR (50 nM), in MG-63 human osteosarcoma cells. Therefore, cellular and molecular techniques, such as MTT assay, flow cytometry, real-time Polymerase Chain Reaction (PCR), western blot and Elisa method, as well as Nuclear Magnetic Resonance (NMR) spectroscopy, were applied to unveil changes in the signal transduction pathways involved in osteosarcoma cells survival. The observed alterations in gene, protein and metabolite levels denote that OLEU not only inhibits MG-63 cells proliferation and potentiates ADR’s cytotoxicity, but also exerts its action, at least in part, through the induction of autophagy.

Sign in / Sign up

Export Citation Format

Share Document