Abstract CT206: PFK-158, first-in-man and first-in-class inhibitor of PFKFB3/ glycolysis: A phase I, dose escalation, multi-center study in patients with advanced solid malignancies

2015 ◽  
Author(s):  
Rebecca Redman ◽  
Paula Pohlmann ◽  
Michael Kurman ◽  
Gilles H. Tapolsky ◽  
Jason Chesney
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Solid Malignancies ◽  
Multi Center Study ◽  
Center Study

A phase I, dose-escalation, multi-center study of PFK-158 in patients with advanced solid malignancies explores a first-in-man inhbibitor of glycolysis.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. TPS2606-TPS2606 ◽  
Author(s):  
Rebecca A. Redman ◽  
Paula Raffin Pohlmann ◽  
Michael R. Kurman ◽  
Gilles Tapolsky ◽  
Jason Alan Chesney
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Solid Malignancies ◽  
Multi Center Study ◽  
Center Study

Phase I Dose-Escalation and Pharmacokinetic Study of Intravenous Aflibercept in Combination with Docetaxel, Cisplatin, and 5-Fluorouracil in Patients with Advanced Solid Malignancies

Oncology ◽  
2015 ◽  
Vol 90 (1) ◽  
pp. 10-20 ◽  
Author(s):  
Rastislav Bahleda ◽  
Jackie Baker ◽  
Christophe Massard ◽  
Sirish M. Gadgeel ◽  
Jane E. Rogers ◽  
...  
Keyword(s):  
Phase I ◽  
Pharmacokinetic Study ◽  
Dose Escalation ◽  
Solid Malignancies

A phase I, open-label, multi-center study of the JAK2 inhibitor AZD1480 in patients with myelofibrosis

2015 ◽  
Vol 39 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Srdan Verstovsek ◽  
Ronald Hoffman ◽  
John Mascarenhas ◽  
Jean-Charles Soria ◽  
Ratislav Bahleda ◽  
...  
Keyword(s):  
Phase I ◽  
Open Label ◽  
Jak2 Inhibitor ◽  
Multi Center Study ◽  
Center Study

scholarly journals A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies

2015 ◽  
Vol 112 (4) ◽  
pp. 650-659 ◽  
Author(s):  
A Spreafico ◽  
J-P Delord ◽  
L De Mattos-Arruda ◽  
Y Berge ◽  
J Rodon ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Phase I ◽  
Dose Escalation ◽  
Adult Patients ◽  
Solid Malignancies

9155 Sunitinib combined with pemetrexed and cisplatin in patients with advanced solid malignancies: phase I dose escalation study

2009 ◽  
Vol 7 (2) ◽  
pp. 552
Author(s):  
N. Blais ◽  
D.R. Camidge ◽  
D.J. Jonker ◽  
D. Soulières ◽  
R.C. Doebele ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Dose Escalation Study ◽  
Solid Malignancies
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