Abstract 5591: Analytical and clinical validation of blood-based NGS panel for detection of genomic alterations in DNA repair pathways

2018 ◽  
Author(s):  
Zhixin Zhao
Keyword(s):  
Dna Repair ◽  
Clinical Validation ◽  
Genomic Alterations ◽  
Repair Pathways

scholarly journals NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non‐inflammatory breast cancers

2020 ◽  
Vol 14 (3) ◽  
pp. 504-519 ◽  
Author(s):  
François Bertucci ◽  
Charlotte Rypens ◽  
Pascal Finetti ◽  
Arnaud Guille ◽  
José Adélaïde ◽  
...  
Keyword(s):  
Dna Repair ◽  
Breast Cancers ◽  
Genomic Alterations ◽  
Repair Pathways

scholarly journals Exploring the Eco-Evolutionary Dynamics of Tumor Subclones

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3436
Author(s):  
Theodoros Rampias
Keyword(s):  
Dna Repair ◽  
Tumor Cells ◽  
Evolutionary Dynamics ◽  
Cancer Genome ◽  
Genomic Alterations ◽  
Repair Pathways ◽  
Mutational Processes

Mutational processes constantly shape the cancer genome and defects in DNA repair pathways of tumor cells facilitate the accumulation of genomic alterations [...]

scholarly journals Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 381
Author(s):  
Danielle P. Johnson ◽  
Mahesh B. Chandrasekharan ◽  
Marie Dutreix ◽  
Srividya Bhaskara
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Therapeutic Intervention ◽  
Synthetic Lethality ◽  
Checkpoint Proteins ◽  
Cellular Processes ◽  
Repair Pathways ◽  
Made In

Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some of the key advancements made in DNA repair-based therapeutics and what is known regarding crosstalk between chromatin and repair pathways during various cellular processes, with an emphasis on cancer.

17α-ethynilestradiol and tributyltin mixtures modulates the expression of NER and p53 DNA repair pathways in male zebrafish gonads and disrupt offspring embryonic development

2018 ◽  
Vol 95 ◽  
pp. 1008-1018 ◽  
Author(s):  
Joana Soares ◽  
Teresa Neuparth ◽  
Angeliki Lyssimachou ◽  
Daniela Lima ◽  
Ana André ◽  
...  
Keyword(s):  
Dna Repair ◽  
Embryonic Development ◽  
Repair Pathways

Investigation on modulation of DNA repair pathways in Chinese MJD patients

2018 ◽  
Vol 71 ◽  
pp. 267.e5-267.e6 ◽  
Author(s):  
Chunrong Wang ◽  
Zhao Chen ◽  
Huirong Peng ◽  
Yun Peng ◽  
Xin Zhou ◽  
...  
Keyword(s):  
Dna Repair ◽  
Repair Pathways

scholarly journals DNA repair pathways as targets for cancer therapy

2008 ◽  
Vol 8 (3) ◽  
pp. 193-204 ◽  
Author(s):  
Thomas Helleday ◽  
Eva Petermann ◽  
Cecilia Lundin ◽  
Ben Hodgson ◽  
Ricky A. Sharma
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Repair Pathways

Modulating DNA Repair Pathways to Improve Precision Genome Engineering

2017 ◽  
Vol 13 (2) ◽  
pp. 389-396 ◽  
Author(s):  
Katherine S. Pawelczak ◽  
Navnath S. Gavande ◽  
Pamela S. VanderVere-Carozza ◽  
John J. Turchi
Keyword(s):  
Dna Repair ◽  
Genome Engineering ◽  
Repair Pathways
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