17α-ethynilestradiol and tributyltin mixtures modulates the expression of NER and p53 DNA repair pathways in male zebrafish gonads and disrupt offspring embryonic development

2018 ◽  
Vol 95 ◽  
pp. 1008-1018 ◽  
Author(s):  
Joana Soares ◽  
Teresa Neuparth ◽  
Angeliki Lyssimachou ◽  
Daniela Lima ◽  
Ana André ◽  
...  
Keyword(s):  
Dna Repair ◽  
Embryonic Development ◽  
Repair Pathways

scholarly journals Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 381
Author(s):  
Danielle P. Johnson ◽  
Mahesh B. Chandrasekharan ◽  
Marie Dutreix ◽  
Srividya Bhaskara
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Therapeutic Intervention ◽  
Synthetic Lethality ◽  
Checkpoint Proteins ◽  
Cellular Processes ◽  
Repair Pathways ◽  
Made In

Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some of the key advancements made in DNA repair-based therapeutics and what is known regarding crosstalk between chromatin and repair pathways during various cellular processes, with an emphasis on cancer.

scholarly journals Highly Specialized Ubiquitin-Like Modifications: Shedding Light into the UFM1 Enigma

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 255
Author(s):  
Katharina F. Witting ◽  
Monique P.C. Mulder
Keyword(s):  
Dna Repair ◽  
Stress Response ◽  
Embryonic Development ◽  
Er Stress ◽  
Unmet Needs ◽  
Biological Function ◽  
Post Translational Modification ◽  
Er Stress Response ◽  
Cellular Events ◽  
Complex Signaling

Post-translational modification with Ubiquitin-like proteins represents a complex signaling language regulating virtually every cellular process. Among these post-translational modifiers is Ubiquitin-fold modifier (UFM1), which is covalently attached to its substrates through the orchestrated action of a dedicated enzymatic cascade. Originally identified to be involved embryonic development, its biological function remains enigmatic. Recent research reveals that UFM1 regulates a variety of cellular events ranging from DNA repair to autophagy and ER stress response implicating its involvement in a variety of diseases. Given the contribution of UFM1 to numerous pathologies, the enzymes of the UFM1 cascade represent attractive targets for pharmacological inhibition. Here we discuss the current understanding of this cryptic post-translational modification especially its contribution to disease as well as expand on the unmet needs of developing chemical and biochemical tools to dissect its role.

Investigation on modulation of DNA repair pathways in Chinese MJD patients

2018 ◽  
Vol 71 ◽  
pp. 267.e5-267.e6 ◽  
Author(s):  
Chunrong Wang ◽  
Zhao Chen ◽  
Huirong Peng ◽  
Yun Peng ◽  
Xin Zhou ◽  
...  
Keyword(s):  
Dna Repair ◽  
Repair Pathways

scholarly journals DNA repair pathways as targets for cancer therapy

2008 ◽  
Vol 8 (3) ◽  
pp. 193-204 ◽  
Author(s):  
Thomas Helleday ◽  
Eva Petermann ◽  
Cecilia Lundin ◽  
Ben Hodgson ◽  
Ricky A. Sharma
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Repair Pathways

Modulating DNA Repair Pathways to Improve Precision Genome Engineering

2017 ◽  
Vol 13 (2) ◽  
pp. 389-396 ◽  
Author(s):  
Katherine S. Pawelczak ◽  
Navnath S. Gavande ◽  
Pamela S. VanderVere-Carozza ◽  
John J. Turchi
Keyword(s):  
Dna Repair ◽  
Genome Engineering ◽  
Repair Pathways

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans

2021 ◽  
Vol 200 ◽  
pp. 111573
Author(s):  
Lucile Marchal ◽  
Shruthi Hamsanathan ◽  
Roshan Karthikappallil ◽  
Suhao Han ◽  
Himaly Shinglot ◽  
...  
Keyword(s):  
Dna Repair ◽  
Caenorhabditis Elegans ◽  
Repair Pathways
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