Abstract 1208: Identifying a novel glycolytic inhibitor for treatment of aggressive prostate cancer

Author(s):  
Tanya Ivanova Stoyanova
2004 ◽  
Vol 171 (4S) ◽  
pp. 124-124 ◽  
Author(s):  
Christopher J. Kane ◽  
William W. Bassett ◽  
Natalia Sadetsky ◽  
Stephanie J. Silva ◽  
David J. Pasta ◽  
...  

2005 ◽  
Vol 173 (4S) ◽  
pp. 383-383
Author(s):  
Susan L. Naylor ◽  
Xin He ◽  
RuiHua Xiang ◽  
Dawn K. Garcia ◽  
Edith D. Canby-Hagino ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1495
Author(s):  
Tú Nguyen-Dumont ◽  
James G. Dowty ◽  
Robert J. MacInnis ◽  
Jason A. Steen ◽  
Moeen Riaz ◽  
...  

While gene panel sequencing is becoming widely used for cancer risk prediction, its clinical utility with respect to predicting aggressive prostate cancer (PrCa) is limited by our current understanding of the genetic risk factors associated with predisposition to this potentially lethal disease phenotype. This study included 837 men diagnosed with aggressive PrCa and 7261 controls (unaffected men and men who did not meet criteria for aggressive PrCa). Rare germline pathogenic variants (including likely pathogenic variants) were identified by targeted sequencing of 26 known or putative cancer predisposition genes. We found that 85 (10%) men with aggressive PrCa and 265 (4%) controls carried a pathogenic variant (p < 0.0001). Aggressive PrCa odds ratios (ORs) were estimated using unconditional logistic regression. Increased risk of aggressive PrCa (OR (95% confidence interval)) was identified for pathogenic variants in BRCA2 (5.8 (2.7–12.4)), BRCA1 (5.5 (1.8–16.6)), and ATM (3.8 (1.6–9.1)). Our study provides further evidence that rare germline pathogenic variants in these genes are associated with increased risk of this aggressive, clinically relevant subset of PrCa. These rare genetic variants could be incorporated into risk prediction models to improve their precision to identify men at highest risk of aggressive prostate cancer and be used to identify men with newly diagnosed prostate cancer who require urgent treatment.


2017 ◽  
Vol 19 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Patricia Canto ◽  
Jesús Benítez Granados ◽  
Guillermo Feria-Bernal ◽  
Ramón Mauricio Coral-Vázquez ◽  
Eduardo García-García ◽  
...  

2007 ◽  
Vol 6 (2) ◽  
pp. 250
Author(s):  
S. Shariat ◽  
J. Karam ◽  
R. Ashfaq ◽  
P. Karakiewicz ◽  
C. Roehrborn

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