Abstract 2509:RB1-loss in castration-resistant prostate cancer reprograms androgen receptor signaling and confers vulnerability to LSD1 inhibition

2021 ◽  
Author(s):  
Wanting Han ◽  
Mingyu Liu ◽  
Dong Han ◽  
Muqing Li ◽  
Anthia A. Toure ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Signaling ◽  
Castration Resistant Prostate Cancer ◽  
Androgen Receptor Signaling ◽  
Castration Resistant

scholarly journals Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (34) ◽  
pp. 35542-35555 ◽  
Author(s):  
Sven Perner ◽  
Marcus V. Cronauer ◽  
Andres Jan Schrader ◽  
Helmut Klocker ◽  
Zoran Culig ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Signaling ◽  
Castration Resistant Prostate Cancer ◽  
Adaptive Responses ◽  
Androgen Receptor Signaling ◽  
Castration Resistant

scholarly journals Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 352 ◽  
Author(s):  
Namrata Khurana ◽  
Suresh Sikka
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Inflammatory Response ◽  
Pivotal Role ◽  
Receptor Signaling ◽  
Castration Resistant Prostate Cancer ◽  
Androgen Receptor Signaling ◽  
Critical Pathways ◽  
Castration Resistant

Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in the initiation, development and progression of prostate cancer (PCa). Numerous papers in the literature have documented the interconnection between oxidative stress and inflammation; and how antioxidants can combat the inflammation. It has been shown in the literature that both oxidative stress and inflammation regulate AR, the key receptor involved in the transition of PCa to castration resistant prostate cancer (CRPC). In this review, we discuss about the importance of targeting Nrf-2-antioxidant signaling, NF-κB inflammatory response and AR signaling in PCa. Finally, we discuss about the crosstalk between these three critical pathways as well as how the anti-inflammatory antioxidant phytochemicals like sulforaphane (SFN) and curcumin (CUR), which can also target AR, can be ideal candidates in the chemoprevention of PCa.

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