Abstract 5196: Vorinostat exhibits anticancer effects through modulation of nuclear receptors and tumor suppressor genes in sub-types of triple negative breast cancer cells

2019 ◽  
Author(s):  
Fatemeh NouriEmamzadeh ◽  
Beverly Word ◽  
Ebony Cotton ◽  
Kai Littlejohn ◽  
Gustavo Miranda-Carboni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Nuclear Receptors ◽  
Triple Negative Breast Cancer ◽  
Tumor Suppressor Genes ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Suppressor Genes ◽  
Anticancer Effects

scholarly journals Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87850 ◽  
Author(s):  
Katarzyna Szarc vel Szic ◽  
Ken Op de Beeck ◽  
Dariusz Ratman ◽  
An Wouters ◽  
Ilse M. Beck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Withania Somnifera ◽  
Triple Negative ◽  
Withaferin A ◽  
Anticancer Effects

scholarly journals Targeting DNA methylation for treating triple-negative breast cancer

2019 ◽  
Vol 20 (16) ◽  
pp. 1151-1157 ◽  
Author(s):  
Jia Yu ◽  
Jacqueline Zayas ◽  
Bo Qin ◽  
Liewei Wang
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Tumor Suppressor ◽  
Triple Negative Breast Cancer ◽  
Targeted Therapies ◽  
Tumor Suppressor Genes ◽  
Dna Methyltransferase ◽  
Triple Negative ◽  
Suppressor Genes ◽  
Dna Methyltransferase Inhibitors

Triple-negative breast cancer (TNBC) accounts for 15–20% of all invasive breast cancers and tends to have aggressive histological features and poor clinical outcomes. Unlike, estrogen receptor- or HER2-positive diseases, TNBC patients currently lack the US FDA-approved targeted therapies. DNA methylation is a critical mechanism of epigenetic modification. It is well known that aberrant DNA methylation contributes to the malignant transformation of cells by silencing critical tumor suppressor genes. DNA methyltransferase inhibitors reactivate silenced tumor suppressor genes and result in tumor growth arrest, with therapeutic effects observed in patients with hematologic malignancies. The antitumor effect of these DNA methyltransferase inhibitors has also been explored in solid tumors, especially in TNBC that currently lacks targeted therapies.

scholarly journals REVERSAL OF HYPERMETHYLATION AND REACTIVATION OF TUMOR SUPPRESSOR GENES DUE TO NATURAL COMPOUNDS IN BREAST CANCER CELLS

2020 ◽  
Vol 02 (01) ◽  
pp. 63-75
Author(s):  
Debasray Saha ◽  
Neeraj Vaishnav ◽  
Zubiya Ahsan ◽  
Nisha Rani ◽  
Runjhun Mathur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Breast Cancer Cells ◽  
Natural Compounds ◽  
Suppressor Genes

scholarly journals Identification of New Tumor Suppressor Genes in Triple-Negative Breast Cancer

2017 ◽  
Vol 77 (15) ◽  
pp. 4089-4101 ◽  
Author(s):  
Roberto Rangel ◽  
Liliana Guzman-Rojas ◽  
Takahiro Kodama ◽  
Michiko Kodama ◽  
Justin Y. Newberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Triple Negative Breast Cancer ◽  
Tumor Suppressor Genes ◽  
Triple Negative ◽  
Suppressor Genes

GPER functions as a tumor suppressor in triple-negative breast cancer cells

2014 ◽  
Vol 140 (5) ◽  
pp. 713-723 ◽  
Author(s):  
Christine Weißenborn ◽  
Tanja Ignatov ◽  
Hans-Joachim Ochel ◽  
Serban Dan Costa ◽  
Ana Claudia Zenclussen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative
Sign in / Sign up

Export Citation Format

Share Document