Abstract IA22: Myeloid derived suppressor cells as mediators of local immune suppression in head and neck cancer

2017 ◽  
Author(s):  
Clint T. Allen
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Immune Suppression ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

scholarly journals Invariant NKT cells are resistant to circulating CD15 + myeloid‐derived suppressor cells in patients with head and neck cancer

2016 ◽  
Vol 107 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Atsushi Horinaka ◽  
Daiju Sakurai ◽  
Fumie Ihara ◽  
Yuji Makita ◽  
Naoki Kunii ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Suppressor Cells ◽  
Nkt Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Invariant Nkt Cells

Inhibition of JAK2/STAT3 reduces tumor-induced angiogenesis and myeloid-derived suppressor cells in head and neck cancer

2017 ◽  
Vol 57 (3) ◽  
pp. 429-439 ◽  
Author(s):  
Jian-Feng Liu ◽  
Wei-Wei Deng ◽  
Lei Chen ◽  
Yi-Cun Li ◽  
Lei Wu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

Inhibition of SRC family kinases reduces myeloid-derived suppressor cells in head and neck cancer

2016 ◽  
Vol 140 (5) ◽  
pp. 1173-1185 ◽  
Author(s):  
Liang Mao ◽  
Wei-Wei Deng ◽  
Guang-Tao Yu ◽  
Lin-Lin Bu ◽  
Jian-Feng Liu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Suppressor Cells ◽  
Src Family Kinases ◽  
Myeloid Derived Suppressor Cells

scholarly journals Gene Therapy for Head and Neck Cancer Using Vaccinia Virus Expressing IL-2 in a Murine Model, with Evidence of Immune Suppression

2001 ◽  
Vol 4 (6) ◽  
pp. 551-558 ◽  
Author(s):  
Hongxing Qin ◽  
Joseph Valentino ◽  
Subha Manna ◽  
Pulak K. Tripathi ◽  
Malaya Bhattacharya-Chatterjee ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Vaccinia Virus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Immune Suppression ◽  
Murine Model

Effects of Radiation Therapy on T-Lymphocyte Subpopulations in Patients with Head and Neck Cancer

1985 ◽  
Vol 93 (5) ◽  
pp. 650-660 ◽  
Author(s):  
William C. Gray ◽  
Paul B. Chretien ◽  
Charles M. Suter ◽  
Daniel R. Revie ◽  
Vesna T. Tomazic ◽  
...  
Keyword(s):  
T Cells ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Suppressor Cells ◽  
Lymphocyte Subpopulations ◽  
Control Group ◽  
Immune Reactivity ◽  
Helper Cells

Cellular immunity was assessed in 85 patients with head and neck cancer with monoclonal antibodies to lymphocyte surface antigens that identify total T cells, helper cells, and suppressor cells. The control group consisted of 22 healthy volunteers. Nine patients who had surgical procedures for benign diseases were also studied. Compared with the controls, the patients with cancer who received radiation therapy had a significant decrease in total lymphocytes, T cells, helper cells, suppressor cells, and decreased helper/suppressor cell ratio. Significant decreases in lymphocyte subpopulations were not detected in patients tested before treatment or in patients treated with surgery alone. The immune deficits observed were prolonged in duration, with some present in the patients studied up to 11 years after radiation therapy. This long-lasting immune depression may have relevance to tumor recurrences and second primaries in patients with head and neck cancer treated by radiation therapy and to attempts at increasing cure rates with adjuvant agents that improve Immune reactivity.

Phase IB study of 25-hydroxyvitamin D3 treatment to diminish suppressor cells in head and neck cancer patients

2001 ◽  
Vol 62 (11) ◽  
pp. 1282-1293 ◽  
Author(s):  
Deanne M.R. Lathers ◽  
Joseph I. Clark ◽  
Nicholas J. Achille ◽  
M.Rita I. Young
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Suppressor Cells ◽  
Phase Ib
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