Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer

Cellular immunity was assessed in 85 patients with head and neck cancer with monoclonal antibodies to lymphocyte surface antigens that identify total T cells, helper cells, and suppressor cells. The control group consisted of 22 healthy volunteers. Nine patients who had surgical procedures for benign diseases were also studied. Compared with the controls, the patients with cancer who received radiation therapy had a significant decrease in total lymphocytes, T cells, helper cells, suppressor cells, and decreased helper/suppressor cell ratio. Significant decreases in lymphocyte subpopulations were not detected in patients tested before treatment or in patients treated with surgery alone. The immune deficits observed were prolonged in duration, with some present in the patients studied up to 11 years after radiation therapy. This long-lasting immune depression may have relevance to tumor recurrences and second primaries in patients with head and neck cancer treated by radiation therapy and to attempts at increasing cure rates with adjuvant agents that improve Immune reactivity.

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Phase IB study of 25-hydroxyvitamin D3 treatment to diminish suppressor cells in head and neck cancer patients

Human Immunology ◽

10.1016/s0198-8859(01)00317-2 ◽

2001 ◽

Vol 62 (11) ◽

pp. 1282-1293 ◽

Cited By ~ 12

Author(s):

Deanne M.R. Lathers ◽

Joseph I. Clark ◽

Nicholas J. Achille ◽

M.Rita I. Young

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Suppressor Cells ◽

Phase Ib

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The absence of lymphoid suppressor cells in tumor-involved lymph nodes of patients with head and neck cancer

Cellular Immunology ◽

10.1016/0008-8749(90)90286-z ◽

1990 ◽

Vol 130 (2) ◽

pp. 446-458 ◽

Cited By ~ 32

Author(s):

Eric M. Letessier ◽

Manuela Sacchi ◽

Jonas T. Johnson ◽

Ronald B. Herberman ◽

Theresa L. Whiteside

Keyword(s):

Head And Neck Cancer ◽

Lymph Nodes ◽

Head And Neck ◽

Neck Cancer ◽

Suppressor Cells

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CD34+ immune suppressor cells in the blood of patients with head and neck cancer

Otolaryngology ◽

10.1016/s0194-5998(97)80094-0 ◽

1997 ◽

Vol 117 (2) ◽

pp. P79-P79

Author(s):

R PANDIT ◽

M WRIGH ◽

T GARRITY ◽

M YOUNG

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Suppressor Cells ◽

Immune Suppressor Cells ◽

Immune Suppressor

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Magnesium in Head and Neck Cancer

International Journal of Research in Science ◽

10.24178/ijrs.2015.1.1.01 ◽

2015 ◽

Vol 1 (1) ◽

pp. 1

Author(s):

Oliver Micke ◽

Ralph Mucke ◽

Klaus Kisters ◽

Jens Buntzel

Keyword(s):

Head And Neck Cancer ◽

Serum Concentration ◽

Head And Neck ◽

Neck Cancer ◽

Normal Population ◽

Neck Region ◽

Controlled Study ◽

Control Group ◽

Advanced Head ◽

Serum Concentrations

We investigated the hypothesis that patients with advanced head and neck cancer exhibit a decreased serum concentration of magnesium compared to the normal population. In July 2013 we measured the magnesium serum concentration of 18 patients with squamous cell carcinoma of the head and neck region. The control group consisted of 17 patients received tonsillectomy during the same period. Overall 14/18 patients with cancer have had Magnesium serum concentrations < 0.80 mmol/l (78%). The control group showed only two patients (12%) with serum levels below the cut off. This small controlled study supports the hypothesis that decreased Magnesium serum concentrations are typical for patients with advanced head and neck cancer. We could not show, that hypomagnesaemia is prognostic biomarker in head and neck cancer treatment.

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