Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells

2016 ◽  
Author(s):  
Marcus M. Fischer ◽  
Wan-Ching Yen ◽  
Fumiko Axelrod ◽  
Christopher Bond ◽  
Jennifer Cain ◽  
...  
Keyword(s):  
Stem Cells ◽  
Monoclonal Antibody ◽  
Cancer Stem Cells ◽  
Tumor Xenografts ◽  
Antibody Targeting

Abstract 2485: Novel monoclonal antibody targeting cancer stem cells

2015 ◽  
Author(s):  
Jeff Holderness ◽  
Amy Turner ◽  
Sam dolezal ◽  
Steve Wolpe ◽  
Michael Pierce ◽  
...  
Keyword(s):  
Stem Cells ◽  
Monoclonal Antibody ◽  
Cancer Stem Cells ◽  
Antibody Targeting

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

Blood ◽  
2014 ◽  
Vol 123 (8) ◽  
pp. 1218-1228 ◽  
Author(s):  
Eva Nievergall ◽  
Hayley S. Ramshaw ◽  
Agnes S. M. Yong ◽  
Mark Biondo ◽  
Samantha J. Busfield ◽  
...  
Keyword(s):  
Stem Cells ◽  
Monoclonal Antibody ◽  
Healthy Donors ◽  
Key Points ◽  
Antibody Targeting

Key Points IL-3 receptor α (CD123) expression is elevated in CML progenitor and stem cells compared with healthy donors. CD123 monoclonal antibody targeting represents a novel, potentially clinically relevant approach to deplete CML progenitor and stem cells.

Selective inhibition of notch signalling and cancer stem cells by an antibody targeting active ADAM10

2016 ◽  
Vol 61 ◽  
pp. S194
Author(s):  
L. Atapattu ◽  
N. Saha ◽  
C. Chheang ◽  
M. Vail ◽  
M. Eissman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Selective Inhibition ◽  
Notch Signalling ◽  
Antibody Targeting

scholarly journals Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors

Leukemia ◽  
2012 ◽  
Vol 26 (9) ◽  
pp. 2124-2134 ◽  
Author(s):  
A Ikegame ◽  
S Ozaki ◽  
D Tsuji ◽  
T Harada ◽  
S Fujii ◽  
...  
Keyword(s):  
Stem Cells ◽  
Transcription Factors ◽  
Cancer Stem Cells ◽  
Small Molecule ◽  
Hla Class I ◽  
Class I ◽  
Antibody Targeting
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