Abstract B40: Suppression of Stat3 inhibits the invasive potential of malignant squamous cell carcinoma by interfering with the HGF/cmet/Stat3 signaling pathway

2010 ◽  
Author(s):  
Zanobia Syed ◽  
Weihong Yin ◽  
Jennifer Gill ◽  
Kendall Hughes ◽  
John L. Clifford
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Invasive Potential ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 550 ◽  
Author(s):  
Jong Hyun Lee ◽  
Shobith Rangappa ◽  
Chakrabhavi Dhananjaya Mohan ◽  
Basappa ◽  
Gautam Sethi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Parp Cleavage ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

STAT3 is a latent transcription factor that plays a vital role in the transmission of extracellular signal from receptors to the nucleus. It has been regarded as a master transcription factor due to its role in the regulation of a broad spectrum of genes, which can contribute to oncogenesis. Persistent activation of STAT3 and deregulation of its signaling has been observed in various human cancers including head and neck squamous cell carcinoma (HNSCC). In the present work, we identified brusatol (BT) as a potential blocker of STAT3 signaling pathway in diverse HNSCC cells. The data from the cell-based experiments suggested that BT-induced cytotoxicity and abrogated the activation of STAT3 and that of upstream kinases such as JAK1, JAK2, and Src. It reduced the levels of nuclear STAT3 and its DNA binding ability. BT treatment increased annexin-V-positive cells, promoted procaspase-3 and PARP cleavage, and downregulated the mRNA and protein expression of diverse proteins (Bcl-2, Bcl-xl, survivin) in HNSCC cells. Taken together, brusatol can function as a promising inhibitor targeting STAT3 signaling pathway in HNSCC.

NME4 modulates PD-L1 expression via the STAT3 signaling pathway in squamous cell carcinoma

2020 ◽  
Vol 526 (1) ◽  
pp. 29-34
Author(s):  
Shutao Zheng ◽  
Qing Liu ◽  
Tao Liu ◽  
Lifei Yang ◽  
Qiqi Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (43) ◽  
pp. 74673-74687 ◽  
Author(s):  
Yi Yang ◽  
Guoguo Jin ◽  
Hangfan Liu ◽  
Kangdong Liu ◽  
Jimin Zhao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway
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