Anastomotic Blood-Flow Reduction in Rat Small Intestine with Chronic Radiation Damage

Digestion ◽  
1998 ◽  
Vol 59 (2) ◽  
pp. 134-141 ◽  
Author(s):  
S. Jahnson ◽  
A. Holtz ◽  
B. Gerdin
Keyword(s):  
Blood Flow ◽  
Small Intestine ◽  
Radiation Damage ◽  
Rat Small Intestine ◽  
Flow Reduction ◽  
Chronic Radiation ◽  
Blood Flow Reduction

Nitric oxide modulates regional blood flow differences in the fetal gastrointestinal tract

1996 ◽  
Vol 271 (4) ◽  
pp. G598-G604 ◽  
Author(s):  
W. Q. Fan ◽  
J. J. Smolich ◽  
J. Wild ◽  
V. Y. Yu ◽  
A. M. Walker
Keyword(s):  
Nitric Oxide ◽  
Heart Rate ◽  
Blood Flow ◽  
Small Intestine ◽  
Vascular Resistance ◽  
Oxygen Delivery ◽  
Intestinal Blood Flow ◽  
Flow Reduction ◽  
Blood Flows ◽  
Blood Flow Reduction

We studied the role of endogenous nitric oxide (NO) in the regulation of gastrointestinal (GI) circulation in 11 chronically instrumented and unanesthetized late-gestation fetal sheep. Systemic and GI blood flows were measured by the radiolabeled microsphere technique. Mean arterial pressure (MAP), heart rate, blood flows, oxygen delivery, and vascular resistance were determined before and after infusion of the specific NO synthase inhibitor, N omega-nitro-L-arginine (L-NNA), to cumulative doses of 10 and 25 mg/kg. At both L-NNA doses, MAP increased, and combined ventricular output and heart rate decreased. GI blood flow and oxygen delivery decreased and vascular resistance increased for the stomach, all segments of the small intestine, and proximal colon and cecum but were unchanged in the middle and distal colon and rectum. Because blood flow reduction in the small intestine was pronounced (from 176 to 107 ml.min-1.100 g-1, P < 0.001) and blood flow in the large intestine was unchanged, distribution of intestinal blood flow became more uniform. Overall, blood flow reduction was proportionally greater in GI circulation than in the remainder of fetal circulation. In three additional animals we established that L-NNA reduced blood flow to the mucosal-submucosal layer (P < 0.02) but not to the muscularis serosa of the small intestine. In the same animals, L-arginine (250 mg/kg) restored systemic hemodynamics and partially restored small intestinal blood flow. Our results suggest that NO is an important differential regulator of vascular tone in the developing GI circulation.

Reduced Mucosal Perianastomotic Capillary Density in Rat Small Intestine with Chronic Radiation Damage

1998 ◽  
Vol 150 (5) ◽  
pp. 542 ◽  
Author(s):  
Staffan Jahnson ◽  
Rolf H. Christofferson ◽  
Bengt Gerdin
Keyword(s):  
Small Intestine ◽  
Radiation Damage ◽  
Capillary Density ◽  
Rat Small Intestine ◽  
Chronic Radiation

scholarly journals Famotidine prevents canine gastric blood flow reduction by NSAIDs

2005 ◽  
Vol 21 (s2) ◽  
pp. 55-59 ◽  
Author(s):  
J. Hata ◽  
T. Kamada ◽  
N. Manabe ◽  
H. Kusunoki ◽  
D. Kamino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gastric Blood Flow ◽  
Flow Reduction ◽  
Blood Flow Reduction

scholarly journals Protein Kinase C Inhibition Prevents Upregulation of Vascular ETB and 5-HT1B Receptors and Reverses Cerebral Blood Flow Reduction after Subarachnoid Haemorrhage in Rats

2006 ◽  
Vol 27 (1) ◽  
pp. 21-32 ◽  
Author(s):  
Saema S Beg ◽  
Jacob A Hansen-Schwartz ◽  
Petter J Vikman ◽  
Cang-Bao Xu ◽  
Lars I Edvinsson
Keyword(s):  
Blood Flow ◽  
Protein Kinase C ◽  
Cerebral Blood Flow ◽  
Protein Kinase ◽  
Subarachnoid Haemorrhage ◽  
Flow Reduction ◽  
Kinase C ◽  
Blood Flow Reduction

scholarly journals Two-stage Operation for Stanford Type B Acute Aortic Dissection with Renal Blood Flow Reduction

2018 ◽  
Vol 79 (4) ◽  
pp. 708-712
Author(s):  
Yusuke SHIMIZU ◽  
Susumu ISHIKAWA ◽  
Hideki MISHIMA ◽  
Yuki MATSUNAGA ◽  
Yuki NISHIHARA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Aortic Dissection ◽  
Renal Blood Flow ◽  
Acute Aortic Dissection ◽  
Type B ◽  
Two Stage ◽  
Flow Reduction ◽  
Blood Flow Reduction ◽  
Stanford Type B

Hepatosplanchnic Vasoregulation and Oxygen Consumption During Selective Aortic Blood Flow Reduction and Reperfusion

2011 ◽  
Vol 171 (2) ◽  
pp. 532-539 ◽  
Author(s):  
Ruy J. Cruz ◽  
Alejandra G. Garrido ◽  
Décio de Natale Caly ◽  
Mauricio Rocha-e-Silva
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Aortic Blood Flow ◽  
Flow Reduction ◽  
Aortic Blood ◽  
Blood Flow Reduction

Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis

Neurology ◽  
2002 ◽  
Vol 59 (3) ◽  
pp. 321-326 ◽  
Author(s):  
M. O'Sullivan ◽  
D. J. Lythgoe ◽  
A. C. Pereira ◽  
P. E. Summers ◽  
J. M. Jarosz ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Reduction ◽  
Blood Flow Reduction

The Morphology of Somatosensory Evoked Potentials During Middle Cerebral Artery Aneurysm Clipping (MoSAC): A Pilot Study

2019 ◽  
Vol 51 (2) ◽  
pp. 130-136
Author(s):  
Franca Tecchio ◽  
Federico Cecconi ◽  
Elisabetta Colamartino ◽  
Matteo Padalino ◽  
Luca Valci ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pilot Study ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Small Sample ◽  
Flow Reduction ◽  
Aneurysm Clipping ◽  
Blood Flow Reduction ◽  
Mca Aneurysm ◽  
Sep Monitoring

Somatosensory evoked potential (SEP) monitoring is a standard tool during clipping of aneurysms of the middle cerebral artery (MCA), and the parameter used to detect a state of cortical ischemia is amplitude. We think that the sensitivity of SEP can however be improved by using other parameters. Our study moves in this direction via SEP morphology. In this pilot preliminary study, involving a small sample without postoperative neurological deficit, we aimed at investigating the value of SEP morphology (in the 15- to 35-ms time frame), in comparison with SEP amplitude (N20 peak-to-peak), as a measure of sensitivity to blood flow reduction. The changes in the SEP morphology of 16 patients undergoing clipping of an unruptured MCA aneurysm was studied. We applied the Morph-Fréchet index for each recorded SEP (at 30-second intervals), quantifying the pattern shape change with regard to the average SEP recorded after dura opening (baseline). We also compared 3 measurements of the SEP morphology, without and with GARCH-derived filter. Filtered Morph-Fréchet never exceeded the individual’s “normality” range in baseline but did so in 81% of the risk phase on average across the 16 subjects, which is more than that for amplitude (36%, P = .002). This pilot study indicates that a measurement derived from the networking nature of the brain was sensitive to blood flow reduction. The SEP morphology approach promises to improve SEP monitoring sensitivity during clipping of unruptured MCA aneurysms. New and Noteworthy. The higher sensitivity to blood flow reduction of SEP morphology than amplitude promises to improve the effectiveness of intraoperative monitoring during MCA aneurysm clipping procedures.

The Resistance Training with Blood Flow Reduction and Vascular Endothelial Function in Healthy Old Volunteers

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 936
Author(s):  
Ryosuke Shimizu ◽  
Kazuki Hotta ◽  
Naoko Aiba ◽  
Daisuke Kamekawa ◽  
Ayako Akiyama ◽  
...  
Keyword(s):  
Blood Flow ◽  
Resistance Training ◽  
Endothelial Function ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Flow Reduction ◽  
Blood Flow Reduction
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