Role of Nitric Oxide in Hypoxia-Induced Changes in Newborn Rats

Neonatology ◽  
2000 ◽  
Vol 78 (3) ◽  
pp. 191-197 ◽  
Author(s):  
İlknur Kiliç ◽  
B. Alper Kiliç ◽  
Cengiz Güven ◽  
Ediz Demirpençe ◽  
M. Arif Akşit
Keyword(s):  
Nitric Oxide ◽  
Newborn Rats ◽  
Induced Changes

scholarly journals The role of Nitric Oxide (NO) in Hypoxia-Induced Changes in Newborn Rats† 1041

1998 ◽  
Vol 43 ◽  
pp. 179-179
Author(s):  
Ilknur Kilic ◽  
B Alper Kilic ◽  
Hacer Ergin ◽  
Cengiz Guven ◽  
M Arif Aksit
Keyword(s):  
Nitric Oxide ◽  
Newborn Rats ◽  
Induced Changes

Nitric oxide decreases lung liquid production via guanosine 3′,5′-cyclic monophosphate

2001 ◽  
Vol 280 (5) ◽  
pp. L923-L929 ◽  
Author(s):  
James J. Cummings ◽  
Huamei Wang
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Epithelium ◽  
Fetal Sheep ◽  
Cgmp Analog ◽  
Pulmonary Arterial ◽  
Series Of Experiments ◽  
Lung Liquid ◽  
Tracer Dilution ◽  
Induced Changes

We studied the role of cGMP in nitric oxide (NO)-induced changes in lung liquid production ( J v ) in chronically instrumented fetal sheep. Forty-five studies were done in which J v was measured by a tracer dilution technique. Left pulmonary arterial flow (Qlpa) was measured by a Doppler flow probe. There were two series of experiments. In the first, we gave 8-bromo-cGMP, a cGMP analog, by either the pulmonary vascular or intraluminal route; in the second, we used agents to inhibit or enhance endogenous cGMP activity. When infused directly into the pulmonary circulation, 8-bromo-cGMP significantly increased Qlpa but had no effect on J v. Conversely, when instilled into the lung liquid, 8-bromo-cGMP had no effect on Qlpa but significantly reduced J v. Inhibition of guanylate cyclase activity with methylene blue totally blocked, whereas phosphodiesterase inhibition with Zaprinast significantly enhanced, the effect of instilled NO on J v. Thus the reduction in lung liquid caused by NO appears to be mediated by cGMP, perhaps through a direct effect on the pulmonary epithelium.

scholarly journals The role of nitric oxide synthase in exercise induced changes in endothelial progenitor cell number

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Patrick Nicholas Colleran ◽  
Miles A. Tanner ◽  
Shena L. Latcham ◽  
Sara L. Collier ◽  
M. Harold Laughlin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Cell Number ◽  
Endothelial Progenitor ◽  
Exercise Induced ◽  
Induced Changes ◽  
Oxide Synthase

scholarly journals The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in newborn rats

1998 ◽  
Vol 125 (7) ◽  
pp. 1455-1462 ◽  
Author(s):  
Anna Radomski ◽  
Grzegorz Sawicki ◽  
David M. Olson ◽  
Marek W. Radomski
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Newborn Rats

Role of nitric oxide in the renal hemodynamic response to a meat meal

1994 ◽  
Vol 267 (4) ◽  
pp. R1050-R1055 ◽  
Author(s):  
F. J. Salazar ◽  
A. Alberola ◽  
T. Nakamura ◽  
J. P. Granger
Keyword(s):  
Nitric Oxide ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Hemodynamic Response ◽  
Synthesis Inhibition ◽  
Renal Hemodynamic ◽  
Meat Meal ◽  
Induced Changes ◽  
Chronically Instrumented Dogs

Ingestion of a high-protein meat meal results in significant increases in renal plasma flow (RPF) and glomerular filtration rate (GFR). The mechanism involved in this hemodynamic response to the meat meal has not yet been fully elucidated. The present study was designed to test the hypothesis that nitric oxide (NO) is involved in the renal hyperemic responses to a meat meal. To test this hypothesis, renal hemodynamic response to a meat meal (10 g/kg) was determined in conscious, chronically instrumented dogs with (n = 9) and without (n = 7) an intrarenal NO synthesis inhibition with NG-nitro-L-arginine methyl ester (L-NAME, 3 micrograms.kg-1.min-1 intrarenally). Under control conditions, the meat meal resulted in significant renal hyperemia. Three hours after ingestion of the meat meal, GFR (43 +/- 3 to 59 +/- 6 ml/min) and RPF (128 +/- 10 to 160 +/- 17 ml/min) progressively increased by approximately 40 and 25%, respectively. In contrast, pretreatment with intrarenal infusion of L-NAME abolished the GFR (48 +/- 6 to 52 +/- 6 ml/min) and RPF (129 +/- 20 to 121 +/- 17 ml/min) increases induced by the meat meal. Pretreatment with L-arginine (0.5 mg.kg-1.min-1) plus L-NAME (3 micrograms.kg-1.min-1) did not modify the meat meal-induced changes in GFR (41 +/- 4 to 66 +/- 6 ml/min) and RPF (127 +/- 9 to 182 +/- 14 ml/min). In summary, a meat meal in dogs results in marked increases in RPF and GFR. Intrarenal NO synthesis inhibition abolished the RPF and GFR responses to the meat meal.(ABSTRACT TRUNCATED AT 250 WORDS)

Role of nitric oxide in alcohol-induced changes in lipid profile of moderate and heavy alcoholics

Alcohol ◽  
2008 ◽  
Vol 42 (1) ◽  
pp. 47-53 ◽  
Author(s):  
G. Kavitha ◽  
V. Damodara Reddy ◽  
M. Paramahamsa ◽  
P.Md. Akhtar ◽  
N.C. Varadacharyulu
Keyword(s):  
Nitric Oxide ◽  
Lipid Profile ◽  
Induced Changes

Selective Inhibition of Nitric Oxide in Hypoxic-Ischemic Brain Model in Newborn Rats: Is It an Explanation for the Protective Role of Erythropoietin?

Neonatology ◽  
2004 ◽  
Vol 85 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Abdullah Kumral ◽  
Huseyin Baskin ◽  
Necati Gokmen ◽  
Osman Yilmaz ◽  
Kursad Genc ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Selective Inhibition ◽  
Protective Role ◽  
Newborn Rats ◽  
Ischemic Brain

Role of paraventricular nucleus in regulation of sympathetic nerve frequency components

2003 ◽  
Vol 284 (5) ◽  
pp. H1710-H1720 ◽  
Author(s):  
Michael J. Kenney ◽  
Mark L. Weiss ◽  
Tammy Mendes ◽  
Yan Wang ◽  
Richard J. Fels
Keyword(s):  
Nitric Oxide ◽  
Paraventricular Nucleus ◽  
Sympathetic Nerve ◽  
Excitatory Amino Acid ◽  
Nitric Oxide Synthase Inhibitor ◽  
Complex Interactions ◽  
Frequency Components ◽  
Synthase Inhibitor ◽  
Induced Changes

Autospectral and coherence analyses were used to determine the role of and interactions between paraventricular nucleus (PVN) nitric oxide, γ-aminobutyric acid (GABA), and the N-methyl-d-aspartic acid (NMDA)-glutamate receptor in regulation of sympathetic nerve discharge (SND) frequency components in anesthetized rats. Four observations were made. First, PVN microinjection of bicuculline (BIC) (GABAAreceptor antagonist), but not single PVN injections of NMDA (excitatory amino acid) or N G-monomethyl-l-arginine (l-NMMA; a nitric oxide synthase inhibitor), altered SND frequency components. Second, combined PVN microinjections ofl-NMMA and NMDA changed the SND bursting pattern; however, the observed pattern change was different from that produced by PVN BIC and not observed after sinoaortic denervation. Third, PVN microinjection of kynurenic acid prevented and reversed BIC-induced changes in the SND bursting pattern. Finally, vascular resistance (renal and splenic) was significantly increased after PVN BIC microinjection despite the lack of change in the level of renal and splenic SND. These data demonstrate that the PVN contains the neural substrate for altering SND frequency components and suggest complex interactions between specific PVN neurotransmitters and between PVN neurotransmitters and the arterial baroreceptor reflex in SND regulation.

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