Ten-Year Follow-Up in a Boy with Leydig Cell Tumor after Selective Surgery

Gynecomastia is a common incidental finding in males that can be caused by various benign or malignant diseases. In rare cases, it results from Leydig cell tumors, a rare entity accounting for 3% of all testicular neoplasms. Some of them are hormonally active but seldom cause symptomatic endocrine disturbance. Here we report on a 32-year-old male presenting with gynecomastia which he had already been suffering from for two years. Although he had been seen by three other specialists, including a urologist, none of them found the small mass in the upper pole of his right testis. We decided to perform testis-sparing surgery which confirmed the diagnosis of a hormonally active Leydig cell tumor. During follow-up, hormonal status normalized, and gynecomastia began to resolve.

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922 LONG-TERM FOLLOW UP USING TESTICULAR SPARING SURGERY FOR LEYDIG CELL TUMOR

The Journal of Urology ◽

10.1016/j.juro.2012.02.1019 ◽

2012 ◽

Vol 187 (4S) ◽

Author(s):

Giorgio Bozzini ◽

Stefano Picozzi ◽

Franco Gadda ◽

Renzo Colombo ◽

Ottavio De Cobelli ◽

...

Keyword(s):

Leydig Cell ◽

Leydig Cell Tumor ◽

Cell Tumor ◽

Long Term Follow Up

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Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor

Clinical Genitourinary Cancer ◽

10.1016/j.clgc.2012.12.008 ◽

2013 ◽

Vol 11 (3) ◽

pp. 321-324 ◽

Cited By ~ 30

Author(s):

Giorgio Bozzini ◽

Stefano Picozzi ◽

Franco Gadda ◽

Renzo Colombo ◽

Ottavio DeCobelli ◽

...

Keyword(s):

Leydig Cell ◽

Leydig Cell Tumor ◽

Cell Tumor ◽

Long Term Follow Up

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Leydig cell tumor of testis- a rare case report

International Surgery Journal ◽

10.18203/2349-2902.isj20174912 ◽

2017 ◽

Vol 4 (11) ◽

pp. 3795

Author(s):

Sheetal Arora ◽

Mukta Pujani ◽

Deepshikha Rana ◽

Narendra Chaudhaury

Keyword(s):

Leydig Cell ◽

Histopathological Examination ◽

Young Patients ◽

Leydig Cell Tumor ◽

Cell Tumor ◽

Positive Staining ◽

Historical Series ◽

Endocrine Profile ◽

Leydig Cell Tumors

Leydig cell tumors(LCTs) of testis are rare testicular tumors of male gonadal interstitium. Although rare, they are most common sex cord stromal tumors and comprise 1-3 % of all testicular neoplasms. They usually occur in fourth to sixth decade. In young patients, they are mostly benign and in adults it can be malignant in about 10 % cases. The incidence of Leydig cell tumors is gradually increasing every year which might be attributed to increased use of radiological techniques and subsequent early detection of tumors that have not been found in historical series. Here we report a case of benign Leydig cell tumor testis in a 45-year-old male who presented with left sided testicular mass. The patient subsequently underwent high inguinal orchidectomy. Histopathological examination showed benign pure Leydig cell tumor. Serological investigations revealed normal testosterone levels, DHEA and androstenedione levels. Immunohistochemical staining for inhibin showed fine granular cytoplasmic positivity and diffuse positive staining for Melan-A which further confirmed the diagnosis. The endocrine profile and imaging investigations of such patients might be normal and patients can be totally asymptomatic. However periodic follow up of endocrine profile and imaging must be done as many cases have been reported which had deranged endocrine levels and appearance of atypical symptoms even after years of unilateral orchidectomy. Our case also presents with normal hormonal levels, henceforth for a better prognosis we must identify benign LCTs and do long term follow up.

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A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman

Japanese Clinical Medicine ◽

10.1177/1179066017695239 ◽

2017 ◽

Vol 8 ◽

pp. 117906601769523 ◽

Cited By ~ 5

Author(s):

Yoko Tsuzuki ◽

Iwaho Kikuchi ◽

Michio Nojima ◽

Koyo Yoshida ◽

Akane Hashizume ◽

...

Keyword(s):

Leydig Cell ◽

Endometrial Hyperplasia ◽

Laparoscopic Hysterectomy ◽

Leydig Cell Tumor ◽

Cell Tumor ◽

Estradiol Level ◽

First Year ◽

Blood Examination ◽

Uterine Endometrium

The patient was a 66-year-old woman, G2P2. The patient presented a chief complaint of irregular postmenopausal bleeding 1 month ago. A transvaginal ultrasonography showed that bilateral ovaries were not enlarged and uterine endometrium was thickened, measuring at 9 mm. As a result of endometrial curettage, the simple endometrial hyperplasia was revealed. A blood examination showed an elevated estradiol level of 67 pg/mL, an elevated level of testosterone 0.64 ng/mL, and a slightly suppressed follicle-stimulating hormone (FSH) level of 34.86 mIU/mL. We conducted laparoscopic hysterectomy and bilateral salpingo-oophorectomy because the patient strongly suggested less invasive surgery. The result of pathological diagnosis was Sertoli-Leydig cell tumor (SLCT) in moderately differentiation. A blood examination after a month postoperatively revealed an elevated FSH level of 85.59 mIU/mL, depressed estradiol level of less than 10 pg/mL, and testosterone level of less than 0.03 ng/mL. There was no evidence of recurrence in the first year of follow-up.

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