Modulation of T Cell Function by Alpha-Fetoprotein: An in vivo Study on Porcine Thyroid Peroxidase-Induced Experimental Autoimmune Thyroiditis in Transgenic Mice Producing Human Alpha-Fetoprotein

Tumor Biology ◽  
1999 ◽  
Vol 20 (3) ◽  
pp. 162-171 ◽  
Author(s):  
E. Matsuura ◽  
Y. Kang ◽  
H. Kitakawa ◽  
A. Ogata ◽  
T. Kotani ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
Autoimmune Thyroiditis ◽  
Cell Function ◽  
Alpha Fetoprotein ◽  
In Vivo Study ◽  
Thyroid Peroxidase ◽  
Experimental Autoimmune Thyroiditis ◽  
Experimental Autoimmune

Experimental autoimmune thyroiditis in human parvovirus B19 transgenic mice

Autoimmunity ◽  
2011 ◽  
Vol 44 (6) ◽  
pp. 483-489 ◽  
Author(s):  
Kouki Mori ◽  
Katsumi Yoshida ◽  
Keiko Ishii ◽  
Kazuki Morohoshi ◽  
Yoshinori Nakagawa ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Autoimmune Thyroiditis ◽  
Parvovirus B19 ◽  
Human Parvovirus B19 ◽  
Experimental Autoimmune Thyroiditis ◽  
Experimental Autoimmune

Unique role of thyroxine in T cell recognition of a pathogenic peptide in experimental autoimmune thyroiditis

1996 ◽  
Vol 26 (4) ◽  
pp. 768-772 ◽  
Author(s):  
Kim I. Dawe ◽  
Patricia R. Hutchings ◽  
Mario Geysen ◽  
Brian R. Champion ◽  
Anne Cooke ◽  
...  
Keyword(s):  
T Cell ◽  
Autoimmune Thyroiditis ◽  
Cell Recognition ◽  
Experimental Autoimmune Thyroiditis ◽  
Unique Role ◽  
T Cell Recognition ◽  
Experimental Autoimmune

scholarly journals Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1β Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis

Endocrinology ◽  
2008 ◽  
Vol 149 (7) ◽  
pp. 3321-3329 ◽  
Author(s):  
Yujiang Fang ◽  
Helen Braley-Mullen
Keyword(s):  
Epithelial Cells ◽  
Autoimmune Thyroiditis ◽  
Death Domain ◽  
Converting Enzyme ◽  
Experimental Autoimmune Thyroiditis ◽  
Inhibitory Protein ◽  
Rna Transfection ◽  
Experimental Autoimmune

The antiapoptotic molecule Fas-associated death domain-like IL-1β-converting enzyme inhibitory protein (FLIP) inhibits Fas-mediated apoptosis by blocking activation of caspase-8. We previously showed that expression of transgenic FLIP on thyroid epithelial cells (TECs) of DBA/1 and CBA/J mice promoted earlier resolution of granulomatous experimental autoimmune thyroiditis in vivo. This study was undertaken to directly determine whether transgenic FLIP expressed on cultured TECs can protect TECs from Fas-mediated apoptosis in vitro. The results indicate that cultured TECs from DBA/1 and CBA/J mice can be sensitized in vitro by interferon-γ and TNF-α to undergo Fas-mediated apoptosis. Transgenic overexpression of FLIP protected cultured TECs of FLIP transgene (Tg)+ DBA/1 and CBA/J mice from Fas-mediated apoptosis, and FLIP small interfering RNA transfection of cultured TECs of FLIP Tg+ DBA/1 and CBA/J mice abolished the protective effect. These in vitro results are consistent with our previous in vivo studies using DBA/1 and CBA/J FLIP Tg+ mice and provide direct support for the hypothesis that transgenic expression of FLIP promotes resolution of granulomatous experimental autoimmune thyroiditis by protecting TECs from apoptosis.

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