Sustained Negativity for HCV-RNA over 24 or More Months by Long-Term Interferon Therapy Correlates with Eradication of HCV in Patients with Hepatitis C Virus Genotype 1b and High Viral Load

Intervirology ◽  
2004 ◽  
Vol 47 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Yasuji Arase ◽  
Fumitaka Suzuki ◽  
Akihito Tsubota ◽  
Yoshiyuki Suzuki ◽  
Satoshi Saitoh ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Interferon Therapy ◽  
High Viral Load ◽  
Hcv Rna ◽  
Virus Genotype ◽  
Genotype 1B

Virological Response in Patients with??Hepatitis C Virus Genotype 1b and??a??High Viral Load

2008 ◽  
Vol 28 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Gotaro Yamada ◽  
Shiro Iino ◽  
Tadao Okuno ◽  
Masao Omata ◽  
Kendo Kiyosawa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Virological Response ◽  
High Viral Load ◽  
Virus Genotype ◽  
Genotype 1B

Serum 25-hydroxyvitamin D3levels affect treatment outcome in pegylated interferon/ribavirin combination therapy for compensated cirrhotic patients with hepatitis C virus genotype 1b and high viral load

2014 ◽  
Vol 44 (13) ◽  
pp. 1277-1285 ◽  
Author(s):  
Masanori Atsukawa ◽  
Akihito Tsubota ◽  
Noritomo Shimada ◽  
Chisa Kondo ◽  
Norio Itokawa ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Pegylated Interferon ◽  
High Viral Load ◽  
Virus Genotype ◽  
Genotype 1B ◽  
Cirrhotic Patients

scholarly journals Efficacy and Changes of the Nonstructural 5A GENE by Prolonged Interferon Therapy for Patients with Hepatitis C Virus genotype 1b and a High Level of Serum HCV-RNA.

1999 ◽  
Vol 38 (6) ◽  
pp. 461-466 ◽  
Author(s):  
Yasuji ARASE ◽  
Kenji IKEDA ◽  
Kazuaki CHAYAMA ◽  
Naoya MURASHIMA ◽  
Akihito TSUBOTA ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Interferon Therapy ◽  
Hcv Rna ◽  
Virus Genotype ◽  
Genotype 1B ◽  
High Level

scholarly journals Hepatitis C virus genotype and its correlation with viral load in patients from Kathmandu, Nepal

2020 ◽  
Vol 14 (12) ◽  
pp. 1470-1474
Author(s):  
Bhavesh Kumar Mishra ◽  
Uday Narayan Yadav ◽  
Saroj Khatiwada ◽  
Man Kumar Tamang ◽  
Shivir Dahal ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
High Viral Load ◽  
Hcv Rna ◽  
Virus Genotype ◽  
Median Viral Load ◽  
Hcv Genotype ◽  
Hcv Genotypes ◽  
Genotype 3A

Introduction: Knowledge about the distribution of hepatitis C virus (HCV) genotype and its correlation with viral load are important for the decision of treatment and the prediction of disease progression, however such information is very limited in Nepal. Here, we investigated the distribution of HCV genotypes and viral load for HCV-infected patients from Kathmandu, Nepal. Methodology: Ninety-six patients with HCV infection and not on antiviral therapy were enrolled from three different medical centers in Kathmandu valley, Nepal. Demographics were recorded and blood samples were collected. Plasma was separated and HCV RNA was extracted. Reverse transcriptase PCR (RT-PCR) was performed to measure the viral load, and virus genotype was determined. Results: Genotype 3a (n = 53, 55.2%) was the most prevalent, followed by 1b (n = 19, 19.8%), 1a (n = 18, 18.8%), 5a (n = 3, 3.1%), and mix types (n = 3, 3.1%). The median viral load for HCV genotype 1a was 770,942 IU/mL (IQR, 215,268-3,720,075), 1b was 700,000 IU/mL (IQR, 431,560-919,000), 3a was 1,060,000 IU/mL (IQR, 641,050-6,063,500), 5a was 673,400 IU/mL, and mixed was 6,428,000 IU/mL. A correlation between genotype and viral load was observed (p = 0.02), of which genotype 3a showed a high viral load. Conclusions: HCV genotypes 1a, 1b, 3a, and 5a were identified in Kathmandu, Nepal, and mixed genotype patients were observed in the patients studied. HCV genotype showed a correlation with viral load in patient plasma. This finding may contribute to the treatment and prevention of hepatitis C in Kathmandu, Nepal.

scholarly journals Interferon Alpha Receptor 2 Expression by Peripheral Blood Monocytes in Patients with a High Viral Load of Hepatitis C Virus Genotype 1 Showing Substitution of Amino Acid 70 in the Core Region

Intervirology ◽  
2010 ◽  
Vol 53 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Koji Ishii ◽  
Mie Shinohara ◽  
Misato Sawa ◽  
Michio Kogame ◽  
Katsuya Higami ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
High Viral Load ◽  
Core Region ◽  
Blood Monocytes ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Peripheral Blood Monocytes ◽  
The Core

scholarly journals Efficacy of Peginterferon plus Ribavirin Treatment in Turkish Patients Infected by Hepatitis C Virus Genotype 1: Comparison of Low and High Viral Load

ANKEM Dergisi ◽  
2011 ◽  
Vol 25 (3) ◽  
pp. 164-168
Author(s):  
Ali Ilgin Olut ◽  
Alpay Ari ◽  
Onur Ozgenc ◽  
Meltem Avci ◽  
Sibel Ozsu Caymaz
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
High Viral Load ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Turkish Patients

Prolonged Negative HCV-RNA Status Led to a Good Outcome in Chronic Hepatitis C Patients with Genotype 1b and Super-High Viral Load

Intervirology ◽  
2006 ◽  
Vol 49 (6) ◽  
pp. 362-369 ◽  
Author(s):  
Hiroshi Kohno ◽  
Shiomi Aimitsu ◽  
Mikiya Kitamoto ◽  
Yasuyuki Aisaka ◽  
Hiroiku Kawakami ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
High Viral Load ◽  
Hcv Rna ◽  
Good Outcome ◽  
Genotype 1B ◽  
Chronic Hepatitis C Patients
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