Cessation of the Electrical Activity of Gonadotropin-Releasing Hormone Pulse Generator during the Steroid-Induced Surge of Luteinizing Hormone in the Rat

1994 ◽  
Vol 59 (6) ◽  
pp. 513-519 ◽  
Author(s):  
Masugi Nishihara ◽  
Akane Sano ◽  
Fukuko Kimura
Keyword(s):  
Luteinizing Hormone ◽  
Electrical Activity ◽  
Pulse Generator ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone

Duration and Frequency of Multiunit Electrical Activity Associated with the Hypothalamic Gonadotropin Releasing Hormone Pulse Generator in the Rhesus Monkey: Differential Effects of Morphine

1990 ◽  
Vol 52 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Cynthia L. Williams ◽  
Masugi Nishihara ◽  
Jean-Christophe Thalabard ◽  
Kevin T. O’Byrne ◽  
Peter M. Grosser ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Electrical Activity ◽  
Pulse Generator ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Differential Effects

In vivo Alterations in the Gonadotropin-Releasing Hormone Pulse Generator and the Secretion and Clearance of Luteinizing Hormone in the Uremic Castrate Rat

1994 ◽  
Vol 59 (3) ◽  
pp. 285-296 ◽  
Author(s):  
Franz Schaefer ◽  
Markus Daschner ◽  
Johannes D. Veldhuis ◽  
Jun Oh ◽  
Fatimunnisa Qadri ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Pulse Generator ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals Phytoestrogens and Gonadotropin-Releasing Hormone Pulse Generator Activity and Pituitary Luteinizing Hormone Release in the Rat*

Endocrinology ◽  
2001 ◽  
Vol 142 (3) ◽  
pp. 1202-1208 ◽  
Author(s):  
Cliona McGarvey ◽  
Philippa S. Cates ◽  
A. Nigel Brooks ◽  
Ian A. Swanson ◽  
Stuart R. Milligan ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Pulse Generator ◽  
Gonadotropin Releasing Hormone ◽  
Hormone Release ◽  
Releasing Hormone ◽  
Luteinizing Hormone Release ◽  
Generator Activity

scholarly journals Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator

2021 ◽  
Vol 118 (5) ◽  
pp. e2009156118
Author(s):  
Mayuko Nagae ◽  
Yoshihisa Uenoyama ◽  
Saki Okamoto ◽  
Hitomi Tsuchida ◽  
Kana Ikegami ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Direct Evidence ◽  
Pulse Generator ◽  
Gonadotropin Releasing Hormone ◽  
Circumstantial Evidence ◽  
Releasing Hormone ◽  
Infertile Women ◽  
Gonadotropin Release ◽  
Kndy Neurons

The gonadotropin-releasing hormone (GnRH) pulse is fundamental for mammalian reproduction: GnRH pulse regimens are needed as therapies for infertile women as continuous GnRH treatment paradoxically inhibits gonadotropin release. Circumstantial evidence suggests that the hypothalamic arcuate KNDy neurons expressing kisspeptin (encoded by Kiss1), neurokinin B (encoded by Tac3), and dynorphin A serve as a GnRH pulse generator; however, no direct evidence is currently available. Here, we show that rescuing >20% KNDy neurons by transfecting Kiss1 inside arcuate Tac3 neurons, but not outside of these neurons, recovered folliculogenesis and luteinizing hormone (LH) pulses, an indicator of GnRH pulses, in female global Kiss1 knockout (KO) rats and that >90% conditional arcuate Kiss1 KO in newly generated Kiss1-floxed rats completely suppressed LH pulses. These results first provide direct evidence that KNDy neurons are the GnRH pulse generator, and at least 20% of KNDy neurons are sufficient to maintain folliculogenesis via generating GnRH/gonadotropin pulses.

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