Infection of Pregnant Guinea Pigs with Attenuated Junin Virus Strains

Intervirology ◽  
1985 ◽  
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Martha C. Boxaca
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...  

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N. R. Nota
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Carolina Jaquenod De Giusti ◽  
Mariela Bollati-Fogolín ◽  
...  

The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.


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