Paradoxical Growth Hormone Response following Thyroid-Stimulating Hormone Administration in the Polycystic Ovary Syndrome

1989 ◽  
Vol 31 (3) ◽  
pp. 119-124 ◽  
Author(s):  
Margarita L.G. Anapliotou ◽  
Kostas Syrigos ◽  
George Panayiotakopoulos ◽  
Alexandros Kalos ◽  
Menelaos L. Batrinos
Keyword(s):  
Growth Hormone ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Thyroid Stimulating Hormone ◽  
Growth Hormone Response ◽  
Hormone Response ◽  
Ovary Syndrome ◽  
Hormone Administration ◽  
Paradoxical Growth ◽  
Stimulating Hormone

Growth hormone response to GHRH, GHRP-6 and GHRH+GHRP-6 in patients with polycystic ovary syndrome

1996 ◽  
Vol 45 (4) ◽  
pp. 385-390 ◽  
Author(s):  
Dragan Micić ◽  
Aleksandra Kenderesˇki ◽  
Vera Popović ◽  
Mirjana Sˇumarac ◽  
Svetlana Zorić ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Growth Hormone Response ◽  
Hormone Response ◽  
Ovary Syndrome

scholarly journals Thyroid-stimulating Hormone and Insulin Resistance: Their Association with Polycystic Ovary Syndrome without Overt Hypothyroidism

2017 ◽  
Vol 39 (05) ◽  
pp. 224-228 ◽  
Author(s):  
Cristina Benetti-Pinto ◽  
Vanessa Piccolo ◽  
Daniela Yela ◽  
Heraldo Garmes
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Thyroid Stimulating Hormone ◽  
Metabolic Parameters ◽  
Overt Hypothyroidism ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Stimulating Hormone

Objective This study analyzed the effectiveness of the thyroid-stimulating hormone (TSH) as a predictor of insulin resistance (IR) and its association with the clinical and metabolic parameters of women with polycystic ovary syndrome (PCOS) without overt hypothyroidism. Study Design A cross-sectional study was performed. Women with PCOS and without overt hypothyroidism (n = 168) were included. Methods Receiver operating characteristic (ROC) curve was used to determine the cut-off point for TSH that would maximize sensitivity and specificity for a diagnosis of IR using homeostatic model assessment of insulin resistance (HOMA-IR) ≥ 2.71. Clinical and metabolic parameters were compared as a function of the TSH cut-off limit and the presence of IR. Results Thyroid-stimulating hormone ≥ 2.77 mIU/L was associated with a diagnosis of IR, with sensitivity of 47.9% and specificity of 65.3%. There were no differences in clinical, hormonal or metabolic parameters between TSH < 2.77 and TSH of 2.77 – 10 mIU/L. Conclusion In women with PCOS without overt hypothyroidism, TSH ≥ 2.77 mIU/L is associated with IR; however, with poor sensibility, showing TSH to be a poor predictor of IR in this population. No clinical or metabolic alterations were found that would justify a change in clinical management. Thus, the IR should be investigated in all women with PCOS irrespective of TSH level.

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